VEGF levels in humans and animal models with RDS and BPD: Temporal relationships

Experimental Lung Research

Volumn 38, Issue 4, 2012, Pages 192-203

  Meller, Stephanie ^a   Bhandari, Vineet ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bronchopulmonary dysplasia; Neonatal lung disease; Respiratory distress syndrome; VEGF

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; INTERLEUKIN 1BETA; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLACENTAL GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; SURFACTANT PROTEIN A; SURFACTANT PROTEIN B; SURFACTANT PROTEIN C; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN 121; VASCULOTROPIN 165; VASCULOTROPIN 189; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN C; VASCULOTROPIN D; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

ANIMAL MODEL; ARTICLE; BIRTH WEIGHT; CHORIOAMNIONITIS; FETUS LUNG MATURATION; GESTATIONAL AGE; HUMAN; HYPEROXIA; LUNG DEVELOPMENT; LUNG DYSPLASIA; LUNG LAVAGE; NEWBORN; NONHUMAN; PREGNANCY DIABETES MELLITUS; PREMATURITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY DISTRESS SYNDROME; TRACHEAL ASPIRATION PROCEDURE;

ANIMALS; BRONCHOPULMONARY DYSPLASIA; DISEASE MODELS, ANIMAL; FEMALE; FETAL ORGAN MATURITY; GESTATIONAL AGE; HUMANS; HYPEROXIA; INFANT, NEWBORN; PREGNANCY; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RESPIRATORY DISTRESS SYNDROME, NEWBORN; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84859446968     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.3109/01902148.2012.663454     Document Type: Article

References (41)

1. D'Angio CT, Maniscalco WM: The role of vascular growth factors in hyperoxia-induced injury to the developing lung. Front Biosci. 2002;7:d1609-d1623.
2. Maniscalco WM, Bhandari V. Disruption of lung mi-crovascular development. In: Abman SH, ed. Bronchopul-monary Dysplasia. New York: Informa Healthcare; 2010:146-166.
3. Maniscalco WM, Watkins RH, D'Angio CT, Ryan RM: Hyper-oxic injury decreases alveolar epithelial cell expression of vascular endothelial growth factor (VEGF) in neonatal rabbit lung. Am J Respir Cell Mol Biol. 1997;16:557-567. (Pubitemid 127498288)
4. Maniscalco WM, Watkins RH, Pryhuber GS, Bhatt A, Shea C, Huyck H: Angiogenic factors and alveolar vasculature: development and alterations by injury in very premature baboons. Am J Physiol Lung Cell Mol Physiol. 2002;282:L811-L823. (Pubitemid 34665598)
5. Bhatt AJ, Amin SB, Chess PR, Watkins RH, Maniscalco WM: Expression of vascular endothelial growth factor and Flk-1 in developing and glucocorticoid-treated mouse lung. Pediatr Res. 2000;47:606-613. (Pubitemid 30249848)
6. D'Angio CT, Maniscalco WM, Ryan RM, Avissar NE, Basave-gowda K, Sinkin RA: Vascular endothelial growth factor in pulmonary lavage fuid from premature infants: effects of age and postnatal dexamethasone. Biol Neonate. 1999;76:266-273. (Pubitemid 29473707)
7. Bhatt AJ, Pryhuber GS, Huyck H, Watkins RH, Metlay LA, Maniscalco WM: Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;164:1971-1980. (Pubitemid 33152338)
8. Bhandari V, Choo-Wing R, Lee CG, Yusuf K, Nedrelow JH, Ambalavanan N, Malkus H, Homer RJ, Elias JA: Developmental regulation of NO-mediated VEGF-induced effects in the lung. Am J Respir Cell Mol Biol. 2008;39:420-430.
9. Mittal N, Sanyal SN: Exogenous surfactant protects against endotoxin induced acute respiratory distress syndrome in ro-dents via vascular endothelial growth factor. Pathol Res Pract. 2011;207:279-284.
10. Been JV, Zoer B, Kloosterboer N, Kessels CG, Zimmermann LJ, van Iwaarden JF, Villamor E: Pulmonary vascular endothe-lial growth factor expression and disaturated phospholipid content in a chicken model of hypoxia-induced fetal growth restriction. Neonatology. 2010;97:183-189.
11. Lassus P, Turanlahti M, Heikkila P, Andersson LC, Nuppo-nen I, Sarnesto A, Andersson S: Pulmonary vascular endothelial growth factor and Flt-1 in fetuses, in acute and chronic lung disease, and in persistent pulmonary hypertension of the newborn. Am J Respir Crit Care Med. 2001;164:1981-1987. (Pubitemid 33152339)
12. Tsao PN, Wei SC, Chou HC, Su YN, Chen CY, Hsieh FJ, Hsieh WS: Vascular endothelial growth factor in preterm infants with respiratory distress syndrome. Pediatr Pulmonol. 2005;39:461-465.
13. Been JV, Debeer A, van Iwaarden JF, Kloosterboer N, Passos VL, Naulaers G, Zimmermann LJ: Early alterations of growth factor patterns in bronchoalveolar lavage fuid from preterm infants developing bronchopulmonary dysplasia. Pediatr Res. 2010;67:83-89.
14. Lassus P, Ristimaki A, Ylikorkala O, Viinikka L, Andersson S: Vascular endothelial growth factor in human preterm lung. Am J Respir Crit Care Med. 1999;159:1429-1433. (Pubitemid 29227849)
15. Currie AE, Vyas JR, MacDonald J, Field D, Kotecha S: Epidermal growth factor in the lungs of infants developing chronic lung disease. Eur Respir J. 2001;18:796-800. (Pubitemid 33076922)
16. Ambalavanan N, Novak ZE: Peptide growth factors in tracheal aspirates of mechanically ventilated preterm neonates. Pediatr Res. 2003;53:240-244. (Pubitemid 36177119)
17. Akeson AL, Cameron JE, Le Cras TD, Whitsett JA, Greenberg JM: Vascular endothelial growth factor-A induces prenatal neo-vascularization and alters bronchial development in mice. Pedi-atr Res. 2005;57:82-88. (Pubitemid 40039897)
18. Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, Plaisance S, Dor Y, Keshet E, Lupu F, Nemery B, Dewerchin M, Van Veldhoven P, Plate K, Moons L, Collen D, Carmeliet P: Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med. 2002;8:702-710. (Pubitemid 34778723)
19. Bental Y, Reichman B, Shiff Y, Weisbrod M, Boyko V, Lerner-Geva L, Mimouni FB: Impact of maternal diabetes mellitus on mortality and morbidity of preterm infants (24-33 weeks' gestation). Pediatrics. 2011;128:e848-e855.
20. Ikeda H, Shiojima I, Oka T, Yoshida M, Maemura K, Walsh K, Igarashi T, Komuro I: Increased Akt-mTOR signaling in lung epithelium is associated with respiratory distress syndrome in mice. Mol Cell Biol. 2011;31:1054-1065.
21. Yanagi S, Kishimoto H, Kawahara K, Sasaki T, Sasaki M, Nishio M, Yajima N, Hamada K, Horie Y, Kubo H, Whitsett JA, Mak TW, Nakano T, Nakazato M, Suzuki A: Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest. 2007;117:2929-2940. (Pubitemid 47529623)
22. Lopez E, Boucherat O, Franco-Montoya ML, Bourbon JR, Delacourt C, Jarreau PH: Nitric oxide donor restores lung growth factor and receptor expression in hyperoxia-exposed rat pups. Am J Respir Cell Mol Biol. 2006;34:738-745. (Pubitemid 43825339)
23. Lin YJ, Markham NE, Balasubramaniam V, Tang JR, Maxey A, Kinsella JP, Abman SH: Inhaled nitric oxide enhances distal lung growth after exposure to hyperoxia in neonatal rats. Pediatr Res. 2005;58:22-29. (Pubitemid 40967424)
24. Wang W, Wei W, Ning Q, Luo XP: Effect of intra-amniotic endotoxin priming plus hyperoxic exposure on the expression of vascular endothelial growth factor and its receptors in lungs of preterm newborn rats. Zhonghua Er Ke Za Zhi. 2007;45:533-538.
25. Thebaud B, Ladha F, Michelakis ED, Sawicka M, Thurston G, Eaton F, Hashimoto K, Harry G, Haromy A, Korbutt G, Archer SL: Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization. Circulation. 2005;112:2477-2486. (Pubitemid 41504498)
26. Hosford GE, Olson DM: Effects of hyperoxia on VEGF, its receptors, and HIF-2alpha in the newborn rat lung. Am J Physiol Lung Cell Mol Physiol. 2003;285:L161-L168. (Pubitemid 36736479)
27. Mager EM, Renzetti G, Auais A, Piedimonte G: Growth factors gene expression in the developing lung. Acta Paediatr. 2007;96:1015-1020. (Pubitemid 46934449)
28. Feng HY, Lu AZ, Zhang XB, Wang LB, Chen C: Effects of prolonged exposure of high concentration of oxygen on expression of vascular endothelial growth factor and its receptors in neonatal rat lungs. Zhongguo Dang Dai Er Ke Za Zhi. 2009;11:927-930.
29. Bland RD, Mokres LM, Ertsey R, Jacobson BE, Jiang S, Rabi-novitch M, Xu L, Shinwell ES, Zhang F, Beasley MA: Mechanical ventilation with 40% oxygen reduces pulmonary expression of genes that regulate lung development and impairs alveolar septation in newborn mice. Am J Physiol Lung Cell Mol Phys-iol. 2007;293:L1099-L1110. (Pubitemid 350159394)
30. Mokres LM, Parai K, Hilgendorff A, Ertsey R, Alvira CM, Ra-binovitch M, Bland RD: Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice. Am J Physiol Lung Cell Mol Physiol. 2010;298:L23-L35.
31. Balasubramaniam V, Mervis CF, Maxey AM, Markham NE, Abman SH: Hyperoxia reduces bone marrow, circulating, and lung endothelial progenitor cells in the developing lung: implications for the pathogenesis of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1073-L1084. (Pubitemid 47084852)
32. Zimova-Herknerova M, Myslivecek J, Potmesil P: Retinoic acid attenuates the mild hyperoxic lung injury in newborn mice. Physiol Res. 2008;57:33-40.
33. Watkins RH, D'Angio CT, Ryan RM, Patel A, Maniscalco WM: Differential expression of VEGF mRNA splice variants in newborn and adult hyperoxic lung injury. Am J Physiol. 1999;276:L858-L867. (Pubitemid 29249639)
34. Maniscalco WM, Watkins RH, Roper JM, Staversky R, O'Reilly MA: Hyperoxic ventilated premature baboons have increased p53, oxidant DNA damage and decreased VEGF expression. Pediatr Res. 2005;58:549-556. (Pubitemid 41254523)
35. Pierce RA, Joyce B, Offcer S, Heintz C, Moore C, McCurnin D, Johnston C, Maniscalco W: Retinoids increase lung elastin expression but fail to alter morphology or angiogenesis genes in premature ventilated baboons. Pediatr Res. 2007;61:703-709. (Pubitemid 46800280)
36. Asikainen TM, Ahmad A, Schneider BK, White CW: Effect of preterm birth on hypoxia-inducible factors and vascular en-dothelial growth factor in primate lungs. Pediatr Pulmonol. 2005;40:538-546. (Pubitemid 41720711)
37. Tambunting F, Beharry KD, Waltzman J, Modanlou HD: Impaired lung vascular endothelial growth factor in extremely premature baboons developing bronchopulmonary dys-plasia/chronic lung disease. J Investig Med. 2005;53:253-262.
38. Kunig AM, Balasubramaniam V, Markham NE, Morgan D, Montgomery G, Grover TR, Abman SH: Recombinant human VEGF treatment enhances alveolarization after hyperoxic lung injury in neonatal rats. Am J Physiol Lung Cell Mol Physiol. 2005;289:L529-L535. (Pubitemid 41361662)
39. Asikainen TM, Chang LY, Coalson JJ, Schneider BK, Waleh NS, Ikegami M, Shannon JM, Winter VT, Grubb P, Clyman RI, Yoder BA, Crapo JD, White CW: Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity. FASEB J. 2006;20:1698-1700.
40. Kunig AM, Balasubramaniam V, Markham NE, Seedorf G, Gien J, Abman SH: Recombinant human VEGF treatment tran-siently increases lung edema but enhances lung structure after neonatal hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2006;291:L1068-L1078. (Pubitemid 44772069)
41. Mura M, dos Santos CC, Stewart D, Liu M: Vascular endothe-lial growth factor and related molecules in acute lung injury. J Appl Physiol. 2004;97:1605-1617. (Pubitemid 39425973)