Effects of prolonged exposure of high concentration of oxygen on expression of vascular endothelial growth factor and its receptors in neonatal rat lungs

Chinese Journal of Contemporary Pediatrics

Volumn 11, Issue 11, 2009, Pages 927-930

  Feng, Hai Yan ^a   Lu, Ai Zhen ^a   Zhang, Xiao Bo ^a   Wang, Li Bo ^a   Chen, Chao ^a  

^a CHILDREN S HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

High concentration of oxygen; Neonatal rats; Receptors, vascular endothelial growth factor; Vascular endothelial growth factor

Indexed keywords

EOSIN; HEMATOXYLIN; MESSENGER RNA; OXYGEN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LUNG BLOOD VESSEL; LUNG DEVELOPMENT; LUNG PARENCHYMA; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANIMALS, NEWBORN; BRONCHOPULMONARY DYSPLASIA; FEMALE; HUMANS; INFANT, NEWBORN; LUNG; MALE; OXYGEN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 71049193906     PISSN: 10088830     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method[J]. Methods, 2001, 25(4):402-408.
2. Hosford GE, Olson DM. Effects of hyperoxia on VEGF, its receptors, and HIF-2αlpha in the newborn rat lung[J]. Am J Physiol Lung Cell Mol Physiol, 2003, 285(1):L161-168.
3. Bourbon J, Boucherat O, Chailley-Heu B, Delacourt C. Control mechanisms of lung alveolar development and their disorders in bronchopulmonary dysplasia[J]. Pediatr Res, 2005, 57 (5 Pt 2):38R-46R. (Pubitemid 40593244)
4. Abman SH. Bronchopulmonary dysplasia: "a vascular hypothesis" [J]. Am J Respir Crit Care Med, 2001, 164(10 Pt 1):1755-1756.
5. Kunig AM, Balasubramaniam V, Markham NE, Morgan D, Montgomery G, Graver TR, et al. Recombinant human VEGF treatment enhances alveolarization after hyperoxic lung injury in neonatal rats[J]. Am J Physiol Lung Cell Mol Physiol, 2005, 289 (4):L529-535.
6. Tang JR, Seedorf G, Balasubramaniam V, Maxey A, Markham N, Abman SH. Early inhaled nitric oxide treatment decreases apoptosis of endothelial cells in neonatal rat lungs after vascular endothelial growth factor inhibition [J]. Am J Physiol Lung Cell Mol Physiol, 2007, 293(5):L1271-L1280. (Pubitemid 350159411)