The chemical synthesis of metabolically stabilized 2-OMe-LPA analogues and preliminary studies of their inhibitory activity toward autotaxin

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2698-2700

  Gendaszewska Darmach, Edyta ^a   Laska, Edyta ^a   Rytczak, Przemysław ^a   Okruszek, Andrzej ^a  

^a LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Autotaxin; Lysophosphatidic acids; Lysophospholipase D; Phosphatases

Indexed keywords

1 O LAUROYL 2 OME LYSOPHOSPHATIDIC ACID; 1 O LAUROYL 2 OME THIOLYSOPHOSPHATIDIC ACID; 1 O MIRYSTOYL 2 OME LYSOPHOSPHATIDIC ACID; 1 O MIRYSTOYL 2 OME THIOLYSOPHOSPHATIDIC ACID; 1 O OLEOYL 2 OME LYSOPHOSPHATIDIC ACID; 1 O OLEOYL 2 OME THIOLYSOPHOSPHATIDIC ACID; 1 O PALMITOYL 2 OME LYSOPHOSPHATIDIC ACID; 1 O PALMITOYL 2 OME THIOLYSOPHOSPHATIDIC ACID; 1 O STEAROYL 2 OME LYSOPHOSPHATIDIC ACID; 1 O STEAROYL 2 OME THIOLYSOPHOSPHATIDIC ACID; ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; AUTOTAXIN; ENZYME INHIBITOR; FATTY ACID; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; PHOSPHORYLATION;

ENZYME INHIBITORS; HUMANS; LYSOPHOSPHOLIPIDS; METHYLATION; MOLECULAR STRUCTURE; PHOSPHORIC DIESTER HYDROLASES; PYROPHOSPHATASES;

EID: 84859443239     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.03.008     Document Type: Article

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