Hedgehog signaling pathway molecules and ALDH1A1 expression in early-stage non-small cell lung cancer

Lung Cancer

Volumn 76, Issue 2, 2012, Pages 191-196

  Raz, Guy ^a   Allen, Kristi E ^a   Kingsley, Chris ^a   Cherni, Irene ^a   Arora, Shilpi ^a   Watanabe, Aprill ^a   Lorenzo, Carlos D ^a   Edwards V, David K ^a   Sridhar, Shravan ^a   Hostetter, Galen ^a   Weiss, Glen J ^a,b  

^a TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^b Virginia G Piper Cancer Center   (United States)

Author keywords

ALDH1A1; Clinical outcome; Hedgehog Signaling Pathway; Immunohistochemistry; Non small cell lung cancer

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; K RAS PROTEIN; PROTEIN ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A1; PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TUMOR MARKER; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER STAGING; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENCE FREE SURVIVAL; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; TISSUE MICROARRAY;

ADULT; AGED; AGED, 80 AND OVER; ALDEHYDE DEHYDROGENASE; CARCINOMA, NON-SMALL-CELL LUNG; DISEASE-FREE SURVIVAL; FEMALE; HEDGEHOG PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIGANDS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 84859434807     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2011.10.015     Document Type: Article

References (27)

1. World Health Organization Cancer institutional fact sheets 2011.
2. Jemal A., Siegel R., Xu J., Ward E. Cancer statistics, 2010. CA: A Cancer Journal for Clinicians 2010, 60:277-300.
3. Stinchcombe T.E, Socinski M.A. Current treatments for advanced stage non-small cell lung cancer. Proceedings of the American Thoracic Society 2009, 6:233-241.
4. Weiss G.J., Von Hoff D.D. Hunting the hedgehog pathway. Clinical Pharmacology and Therapeutics 2010, 87:743-747.
5. Zhang M., Wang H., Teng H., Shi J., Zhang Y. Expression of SHH signaling pathway components in the developing human lung. Histochemistry and Cell Biology 2010, 134:327-335.
6. Barnfield P.C, Zhang X., Thanabalasingham V., Yoshida M., Hui C.C. Negative regulation of Gli1 and Gli2 activator function by suppressor of fused through multiple mechanisms. Differentiation; Research in Biological Diversity 2005, 73:397-405.
7. Wicking C., McGlinn E. The role of hedgehog signalling in tumorigenesis. Cancer Letters 2001, 173:1-7.
8. Sullivan J.P., Spinola M., Dodge M., Raso M.G., Behrens C., Gao B., et al. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Research 2010, 70:9937-9948.
9. Patel M., Lu L., Zander D.S., Sreerama L., Coco D., Moreb J.S. ALDH1A1 and ALDH3A1 expression in lung cancers: correlation with histologic type and potential precursors. Lung Cancer 2008, 59:340-349.
10. Mimeault M., Batra S.K. Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies. Pharmacological Reviews 2010, 62:497-524.
11. Looyenga B.D., Cherni I., Mackeigan J.P., Weiss G.J. Tailoring tyrosine kinase inhibitors to fit the lung cancer genome. Translational Oncology 2011, 4:59-70.
12. Edge S.B., Compton C.C. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Annals of Surgical Oncology 2010, 17:1471-1474.
13. McCarty K.S., Szabo E., Flowers J.L., Cox E.B., Leight G.S., Miller L., et al. Use of a monoclonal anti-estrogen receptor antibody in the immunohistochemical evaluation of human tumors. Cancer Research 1986, 46:4244s-4248s.
14. Heideman D.A., Thunnissen F.B., Doeleman M., Kramer D., Verheul H.M., Smit E.F., et al. A panel of high resolution melting (HRM) technology-based assays with direct sequencing possibility for effective mutation screening of EGFR and K-ras genes. Cellular Oncology: The Official Journal of the International Society for Cellular Oncology 2009, 31:329-333.
15. Kramer D., Thunnissen F.B., Gallegos-Ruiz M.I., Smit E.F., Postmus P.E., Meijer C.J., et al. A fast, sensitive and accurate high resolution melting (HRM) technology-based assay to screen for common K-ras mutations. Cellular Oncology: The Official Journal of the International Society for Cellular Oncology 2009, 31:161-167.
16. Peacock C.D., Watkins D.N. Cancer stem cells and the ontogeny of lung cancer. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 2008, 26:2883-2889.
17. Yuan Z., Goetz J.A., Singh S., Ogden S.K., Petty W.J., Black C.C., et al. Frequent requirement of hedgehog signaling in non-small cell lung carcinoma. Oncogene 2007, 26:1046-1055.
18. Liu M.S., Yang P.Y., Yeh T.S. Sonic hedgehog signaling pathway in pancreatic cystic neoplasms and ductal adenocarcinoma. Pancreas 2007, 34:340-346.
19. Heretsch P., Tzagkaroulaki L., Giannis A. Modulators of the hedgehog signaling pathway. Bioorganic & Medicinal Chemistry 2010, 18:6613-6624.
20. Gialmanidis I.P., Bravou V., Amanetopoulou S.G., Varakis J., Kourea H., Papadaki H. Overexpression of hedgehog pathway molecules and FOXM1 in non-small cell lung carcinomas. Lung Cancer 2009, 66:64-74.
21. Chi S., Huang S., Li C., Zhang X., He N., Bhutani M.S., et al. Activation of the hedgehog pathway in a subset of lung cancers. Cancer Letters 2006, 244:53-60.
22. Chen M., Hildebrandt M.A., Clague J., Kamat A.M., Picornell A., Chang J., et al. Genetic variations in the sonic hedgehog pathway affect clinical outcomes in non-muscle-invasive bladder cancer. Cancer Prevention Research 2010, 3:1235-1245.
23. Dai J., Ai K., Du Y., Chen G. Sonic hedgehog expression correlates with distant metastasis in pancreatic adenocarcinoma. Pancreas 2011, 40:233-236.
24. Al-Halabi H., Nantel A., Klekner A., Guiot M.C., Albrecht S., Hauser P., et al. Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma. Acta Neuropathologica 2011, 121:229-239.
25. Greaves W.O., Kim J.E., Singh R.R., Drakos E., Kunkalla K., Sánchez-Espiridión B., et al. Glioma-associated oncogene homologue 3, a hedgehog transcription factor, is highly expressed in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma. Human Pathology 2011, [Epub ahead of print].
26. Lauth M., Bergström A., Shimokawa T., Tostar U., Jin Q., Fendrich V., et al. DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. Nature Structural & Molecular Biology 2010, 17:718-725.
27. Noubissi F.K., Goswami S., Sanek N.A., Kawakami K., Minamoto T., Moser A., et al. Wnt signaling stimulates transcriptional outcome of the hedgehog pathway by stabilizing GLI1 mRNA. Cancer Research 2009, 69:8572-8578.