Hunting the hedgehog pathway

Clinical Pharmacology and Therapeutics

Volumn 87, Issue 6, 2010, Pages 743-747

  Weiss, G J ^a,b   Von Hoff, D D ^a,b  

^a Virginia G Piper Cancer Center   (United States)

^b TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CYCLOPAMINE; GLYCOGEN SYNTHASE KINASE 3; MEMBRANE PROTEIN; ONCOPROTEIN; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR;

ADULT; CANCER RESEARCH; CASE REPORT; CELL ACTIVATION; GLIA; HOLOPROSENCEPHALY; HUMAN; LAMB; LIGAND BINDING; NEWBORN; NONHUMAN; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CLINICAL TRIALS AS TOPIC; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HEDGEHOG PROTEINS; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 77952581142     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2010.34     Document Type: Review

References (27)

1. Binns, W., James, L.F., Shupe, J.L. & Everett, G. A congenital cyclopian-type malformation in lambs induced by maternal ingestion of a range plant, Veratrum californicum. Am. J. Vet. Res. 24, 1164-1175 (1963).
2. Keeler, R.F. & Binns, W. Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian efects of steroidal alkaloids from the plant and structurally related compounds from other sources. Teratology 1, 5-10 (1968).
3. Cooper, M.K., Porter, J.A., Young, K.E. & Beachy, P.A. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280, 1603-1607 (1998).
4. Lum, L. & Beachy, P.A. The Hedgehog response network: sensors, switches, and routers. Science, 304, 1755-1759 (2004).
5. Chen, M.H. et al. Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23, 1910-1928 (2009).
6. Scales, S.J. & de Sauvage, F.J. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol. Sci. 30, 303-312 (2009).
7. Epstein, E.H. Basal cell carcinomas: attack of the hedgehog. Nat. Rev. Cancer 8, 743-754 (2008).
8. Ingham, P.W. & Placzek, M. Orchestrating ontogenesis: variations on a theme by sonic hedgehog. Nat. Rev. Genet. 7, 841-850 (2006).
9. Piddini, E. & Vincent, J.P. Modulation of developmental signals by endocytosis: diferent means and many ends. Curr. Opin. Cell Biol. 15, 474-481 (2003).
10. Katoh, Y. & Katoh, M. Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review). Int. J. Mol. Med. 22, 271-275 (2008).
11. Ferretti, E. et al. Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO J. 27, 2616-2627 (2008).
12. Schnidar, H. et al. Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/jUN pathway. Cancer Res. 69, 1284-1292 (2009).
13. Jia, J. et al. Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia. Dev. Biol. 330, 452-460 (2009).
14. Flynt, A.S., Li, N., Thatcher, E.J., Solnica-Krezel, L. & Patton, J.G. Zebrafsh miR-214 modulates Hedgehog signaling to specify muscle cell fate. Nat. Genet. 39, 259-263 (2007).
15. Evangelista, M. et al. Kinome siRNA screen identifes regulators of ciliogenesis and hedgehog signal transduction. Sci. Signal. 1, ra7 (2008).
16. Cheung, H.O. et al. The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling. Sci. Signal. 2, ra29 (2009).
17. Pola, R. et al. The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nat. Med. 7, 706-711 (2001).
18. Yoon, J.W. et al. Gene expression profling leads to identifcation of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J. Biol. Chem. 277, 5548-5555 (2002).
19. Bigelow, R.L. et al. Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J. Biol. Chem. 279, 1197-1205 (2004).
20. Feldmann, G. et al. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res. 67, 2187-2196 (2007).
21. Yauch, R.L. et al. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 326, 572-574 (2009).
22. Tostar, U., Malm, C.J., Meis-Kindblom, J.M., Kindblom, L.G., Toftgård, R. & Undén, A.B. Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development. J. Pathol. 208, 17-25 (2006).
23. Von Hof, D.D. et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N. Engl. J. Med. 361, 1164-1172 (2009).
24. Rudin, C.M. et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N. Engl. J. Med. 361, 1173-1178 (2009).
25. Ischenko, I., Seeliger, H., Schafer, M., Jauch, K.W. & Bruns, C.J. Cancer stem cells: how can we target them? Curr. Med. Chem. 15, 3171-3184 (2008).
26. Lauth, M., Bergström, A., Shimokawa, T. & Toftgård, R. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc. Natl. Acad. Sci. USA 104, 8455-8460 (2007).
27. Nelson, K.M. & Weiss, G.J. MicroRNAs and cancer: past, present, and potential future. Mol. Cancer Ther. 7, 3655-3660 (2008).