Test-retest stability of cerebral mGluR 5 quantification using [ 11C]ABP688 and positron emission tomography in rats

Synapse

Volumn 66, Issue 6, 2012, Pages 552-560

  Elmenhorst, David ^a,b,c   Aliaga, Antonio ^c   Bauer, Andreas ^b,d   Rosa Neto, Pedro ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

^c MCGILL UNIVERSITY   (Canada)

^d Department of Orthopedic Surgery   (Germany)

Author keywords

11C ABP688; Kinetic modeling; Positron emission tomography; Test retest

Indexed keywords

ABP 688; CARBON 11; METABOTROPIC RECEPTOR 5; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN TISSUE; CONTROLLED STUDY; CORRELATION COEFFICIENT; KINETICS; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REPRODUCIBILITY; TEST RETEST RELIABILITY; VOXEL BASED MORPHOMETRY;

ALGORITHMS; ANIMALS; BRAIN; BRAIN CHEMISTRY; CARBON RADIOISOTOPES; IMAGE INTERPRETATION, COMPUTER-ASSISTED; KINETICS; MALE; OXIMES; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; REPRODUCIBILITY OF RESULTS;

EID: 84859433211     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.21542     Document Type: Article

References (42)

1. Abi-Dargham A, Gandelman M, Zoghbi SS, Laruelle M, Baldwin RM, Randall P, Zea-Ponce Y, Charney DS, Hoffer PB, Innis RB. 1995. Reproducibility of SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil. J Nucl Med 36: 167-175.
2. Alexoff DL, Vaska P, Marsteller D, Gerasimov T, Li J, Logan J, Fowler JS, Taintor NB, Thanos PK, Volkow ND. 2003. Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activity. J Nucl Med 44: 815-822.
3. Ametamey SM, Kessler LJ, Honer M, Wyss MT, Buck A, Hintermann S, Auberson YP, Gasparini F, Schubiger PA. 2006. Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5. J Nucl Med 47: 698-705.
4. Ametamey SM, Treyer V, Streffer J, Wyss MT, Schmidt M, Blagoev M, Hintermann S, Auberson Y, Gasparini F, Fischer UC, Buck A. 2007. Human PET studies of metabotropic glutamate receptor subtype 5 with 11C-ABP688. J Nucl Med 48: 247-252.
5. Aznavour N, Benkelfat C, Gravel P, Aliaga A, Rosa-Neto P, Bedell B, Zimmer L, Descarries L. 2009. MicroPET imaging of 5-HT 1A receptors in rat brain: A test-retest [18F]MPPF study. Eur J Nucl Med Mol Imaging 36: 53-62.
6. Balschun D, Wetzel W. 2002. Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats. Pharmacol Biochem Behav 73: 375-380.
7. Bikbaev A, Neyman S, Ngomba RT, Conn PJ, Nicoletti F, Manahan-Vaughan D. 2008. MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS One 3: e2155.
8. Brody SA, Dulawa SC, Conquet F, Geyer MA. 2004. Assessment of a prepulse inhibition deficit in a mutant mouse lacking mGlu5 receptors. Mol Psychiatry 9: 35-41.
9. Bruno V, Battaglia G, Copani A, D'Onofrio M, Di IP, De BA, Melchiorri D, Flor PJ, Nicoletti F. 2001. Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs. J Cereb Blood Flow Metab 21: 1013-1033.
10. Cartmell J, Schoepp DD. 2000. Regulation of neurotransmitter release by metabotropic glutamate receptors. J Neurochem 75: 889-907.
11. Casteels C, Vermaelen P, Nuyts J, Van Der LA, Baekelandt V, Mortelmans L, Bormans G, Van LK. 2006. Construction and evaluation of multitracer small-animal PET probabilistic atlases for voxel-based functional mapping of the rat brain. J Nucl Med 47: 1858-1866.
12. Chan GL, Holden JE, Stoessl AJ, Doudet DJ, Wang Y, Dobko T, Morrison KS, Huser JM, English C, Legg B, Schulzer M, Calne DB, Ruth TJ. 1998. Reproducibility of the distribution of carbon-11-SCH 23390, a dopamine D1 receptor tracer, in normal subjects. J Nucl Med 39: 792-797.
13. Chapman AG, Nanan K, Williams M, Meldrum BS. 2000. Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893). Neuropharmacology 39: 1567-1574.
14. Conn PJ, Pin JP. 1997. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37: 205-237.
15. Delorenzo C, Kumar JS, Mann JJ, Parsey RV. 2011a. In vivo variation in metabotropic glutamate receptor subtype 5 binding using positron emission tomography and [(11)C]ABP688. J Cereb Blood Flow Metab 31: 2169-2180.
16. Delorenzo C, Milak MS, Brennan KG, Kumar JS, Mann JJ, Parsey RV. 2011b. In vivo positron emission tomography imaging with [(11)C]ABP688: Binding variability and specificity for the metabotropic glutamate receptor subtype 5 in baboons. Eur J Nucl Med Mol Imaging 38: 1083-1094.
17. Dolen G, Osterweil E, Rao BS, Smith GB, Auerbach BD, Chattarji S, Bear MF. 2007. Correction of fragile X syndrome in mice. Neuron 56: 955-962.
18. Elmenhorst D, Minuzzi L, Aliaga A, Rowley J, Massarweh G, Diksic M, Bauer A, Rosa-Neto P. 2010. In vivo and in vitro validation of reference tissue models for the mGluR(5) ligand [(11)C]ABP688. J Cereb Blood Flow Metab 30: 1538-1549.
19. Faul F, Erdfelder E, Lang AG, Buchner A. 2007. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39: 175-191.
20. Gasparini F, Lingenhohl K, Stoehr N, Flor PJ, Heinrich M, Vranesic I, Biollaz M, Allgeier H, Heckendorn R, Urwyler S, Varney MA, Johnson EC, Hess SD, Rao SP, Sacaan AI, Santori EM, Velicelebi G, Kuhn R. 1999. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 38: 1493-1503.
21. Hammers A, Asselin MC, Turkheimer FE, Hinz R, Osman S, Hotton G, Brooks DJ, Duncan JS, Koepp MJ. 2007. Balancing bias, reliability, noise properties and the need for parametric maps in quantitative ligand PET: [(11)C]diprenorphine test-retest data. Neuroimage 38: 82-94.
22. Hintermann S, Vranesic I, Allgeier H, Brulisauer A, Hoyer D, Lemaire M, Moenius T, Urwyler S, Whitebread S, Gasparini F, Auberson YP. 2007. ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: Identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorg Med Chem 15: 903-914.
23. Huber KM, Kayser MS, Bear MF. 2000. Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression. Science 288: 1254-1257.
24. Ichise M, Liow JS, Lu JQ, Takano A, Model K, Toyama H, Suhara T, Suzuki K, Innis RB, Carson RE. 2003. Linearized reference tissue parametric imaging methods: Application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain. J Cereb Blood Flow Metab 23: 1096-1112.
25. Innis RB, Cunningham VJ, Delforge J, Fujita M, Gjedde A, Gunn RN, Holden J, Houle S, Huang SC, Ichise M, Iida H, Ito H, Kimura Y, Koeppe RA, Knudsen GM, Knuuti J, Lammertsma AA, Laruelle M, Logan J, Maguire RP, Mintun MA, Morris ED, Parsey R, Price JC, Slifstein M, Sossi V, Suhara T, Votaw JR, Wong DF, Carson RE. 2007. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab 27: 1533-1539.
26. Jia Z, Lu Y, Henderson J, Taverna F, Romano C, Bramow-Newerly W, Wojtowicz JM, Roder J. 1998. Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5. Learn Mem 5: 331-343.
27. Kim JS, Ichise M, Sangare J, Innis RB. 2006. PET imaging of serotonin transporters with [11C]DASB: test-retest reproducibility using a multilinear reference tissue parametric imaging method. J Nucl Med 47: 208-214.
28. Kirk RE. 1992. Experimental design: Procedures for the behavioural sciences. Pacific Grove: Brooks/Cole.
29. Knoess C, Siegel S, Smith A, Newport D, Richerzhagen N, Winkeler A, Jacobs A, Goble RN, Graf R, Wienhard K, Heiss WD. 2003. Performance evaluation of the microPET R4 PET scanner for rodents. Eur J Nucl Med Mol Imaging 30: 737-747.
30. Lammertsma AA, Hume SP. 1996. Simplified reference tissue model for PET receptor studies. Neuroimage 4: 153-158.
31. Logan J, Fowler JS, Volkow ND, Wang GJ, Ding YS, Alexoff DL. 1996. Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab 16: 834-840.
32. Lu YM, Jia Z, Janus C, Henderson JT, Gerlai R, Wojtowicz JM, Roder JC. 1997. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci 17: 5196-5205.
33. Marner L, Gillings N, Madsen K, Erritzoe D, Baare WF, Svarer C, Hasselbalch SG, Knudsen GM. 2010. Brain imaging of serotonin 4 receptors in humans with [(11)C]SB207145-PET. Neuroimage 50: 855-861.
34. Miyake N, Skinbjerg M, Easwaramoorthy B, Kumar D, Girgis RR, Xu X, Slifstein M, bi-Dargham A. 2011. Imaging changes in glutamate transmission in vivo with the metabotropic glutamate receptor 5 tracer [(11)C] ABP688 and N-acetylcysteine challenge. Biol Psychiatry 69: 822-824.
35. Mu L, Schubiger PA, Ametamey SM. 2010. Radioligands for the PET imaging of metabotropic glutamate receptor subtype 5 (mGluR5). Curr Top Med Chem 10: 1558-1568.
36. Notenboom RG, Hampson DR, Jansen GH, van Rijen PC, van Veelen CW, van NO, de Graan PN. 2006. Up-regulation of hippocampal metabotropic glutamate receptor 5 in temporal lobe epilepsy patients. Brain 129: 96-107.
37. Paxinos G, Watson C. 1998. The rat brain in stereotaxic coordinates. San Diego: Academic Press.
38. Rubins DJ, Melega WP, Lacan G, Way B, Plenevaux A, Luxen A, Cherry SR. 2003. Development and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain. Neuroimage 20: 2100-2118.
39. Tizzano JP, Griffey KI, Schoepp DD. 1995. Induction or protection of limbic seizures in mice by mGluR subtype selective agonists. Neuropharmacology 34: 1063-1067.
40. Treyer V, Streffer J, Wyss MT, Bettio A, Ametamey SM, Fischer U, Schmidt M, Gasparini F, Hock C, Buck A. 2007. Evaluation of the metabotropic glutamate receptor subtype 5 using PET and 11C-ABP688: assessment of methods. J Nucl Med 48: 1207-1215.
41. Wu Y, Carson RE. 2002. Noise reduction in the simplified reference tissue model for neuroreceptor functional imaging. J Cereb Blood Flow Metab 22: 1440-1452.
42. Wyss MT, Ametamey SM, Treyer V, Bettio A, Blagoev M, Kessler LJ, Burger C, Weber B, Schmidt M, Gasparini F, Buck A. 2007. Quantitative evaluation of 11C-ABP688 as PET ligand for the measurement of the metabotropic glutamate receptor subtype 5 using autoradiographic studies and a beta-scintillator. Neuroimage 35: 1086-1092.