New insights into the structure-cytotoxicity relationship of spirostan saponins and related glycosides

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 8, 2012, Pages 2690-2700

  Pérez Labrada, Karell ^a,b   Brouard, Ignacio ^a   Estévez, Sara ^c   Marrero, María Teresa ^c   Estévez, Francisco ^c   Bermejo, Jaime ^a   Rivera, Daniel G ^b  

^a INSTITUTO DE PRODUCTOS NATURALES Y AGROBIOLOGÍA   (Spain)

^b UNIVERSITY OF HAVANA   (Cuba)

^c UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

Author keywords

Cytotoxicity; HL 60 cell; Saponins; Steroids; Structure activity relationship

Indexed keywords

5ALPHA HYDROXY LAXOGENYL 2 O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSIDE; 5ALPHA HYDROXY LAXOGENYL 2,3 DI O ACETYL BETA DEXTRO GLUCOPYRANOSIDE; 5ALPHA HYDROXY LAXOGENYL 2,3,4,6 TETRA O BENZOYL BETA DEXTRO GLUCOPYRANOSIDE; 5ALPHA HYDROXY LAXOGENYL 2,4 DI O (2,3,4, TRI O ACETYL ALPHA LEVO RHAMNOPYRANOSYL) 3,6 DI O PIVALOYL BETA DEXTRO GLUCOPYRANOSIDE; 5ALPHA HYDROXY LAXOGENYL 2,4 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSIDE; 5ALPHA HYDROXY LAXOGENYL 3,6 DI O PIVALOYL BETA DEXTRO GLUCOPYRANOSIDE; 5ALPHA HYDROXY LAXOGENYL 4,6 DI O (2,3,4, TRI O ACETYL ALPHA LEVO RHAMNOPYRANOSYL) 2,3 DI O ACETYL BETA DEXTRO GLUCOPYRANOSIDE; 5ALPHA HYDROXY LAXOGENYL 4,6 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSIDE; 5ALPHA HYDROXY LAXOGENYL 4,6 O BENZYLIDENE 3 O PIVALOYL BETA DEXTRO GLUCOPYRANOSIDE; GLYCOSIDE; HECOGENYL 2 O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSIDE; HECOGENYL 2,3 DI O ACETYL BETA DEXTRO GLUCOPYRANOSIDE; HECOGENYL 2,3,4,6 TETRA O BENZOYL BETA DEXTRO GLUCOPYRANOSIDE; HECOGENYL 2,4 DI O (2,3,4, TRI O ACETYL ALPHA LEVO RHAMNOPYRANOSYL) 3,6 DI O PIVALOYL BETA DEXTRO GLUCOPYRANOSIDE; HECOGENYL 2,4 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSIDE; HECOGENYL 3,6 DI O PIVALOYL BETA DEXTRO GLUCOPYRANOSIDE; HECOGENYL 4,6 DI O (2,3,4, TRI O ACETYL ALPHA LEVO RHAMNOPYRANOSYL) 2,3 DI O ACETYL BETA DEXTRO GLUCOPYRANOSIDE; HECOGENYL 4,6 DI O (ALPHA LEVO RHAMNOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSIDE; HECOGENYL 4,6 O BENZYLIDENE 3 O PIVALOYL GLUCOPYRANOSIDE; SAPONIN; SPIROSTAN DERIVATIVE; SPIROSTAN SAPONIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GLYCOSYLATION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; GLYCOSIDES; HL-60 CELLS; HUMANS; MOLECULAR CONFORMATION; SAPONINS; SPIROSTANS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84859420523     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.026     Document Type: Article

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