Decreased body weight and hepatic steatosis with altered fatty acid ethanolamide metabolism in aged L-Fabp -/- mice

Journal of Lipid Research

Volumn 53, Issue 4, 2012, Pages 744-754

  Newberry, Elizabeth P ^a   Kennedy, Susan M ^a   Xie, Yan ^a   Luo, Jianyang ^a   Crooke, Rosanne M ^b   Graham, Mark J ^b   Fu, Jin ^c   Piomelli, Daniele ^c,d   Davidson, Nicholas O ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ISIS PHARMACEUTICALS   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

Fatty acid binding protein; Feeding behavior; Obesity; Satiety

Indexed keywords

ANANDAMIDE; FATTY ACID DERIVATIVE; FATTY ACID ETHANOLAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FATTY LIVER; FEEDING BEHAVIOR; FEMALE; FOOD INTAKE; GENE DELETION; GENE FREQUENCY; GENE LOCUS; GENE MAPPING; GENETIC SUSCEPTIBILITY; HYDROLYSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WEIGHT REDUCTION;

ADIPOSITY; AGE FACTORS; AMIDOHYDROLASES; ANIMALS; ARACHIDONIC ACIDS; BODY WEIGHT; CHROMOSOMES; DIET, FAT-RESTRICTED; ENZYME ACTIVATION; FATTY ACID-BINDING PROTEINS; FATTY LIVER; FEEDING BEHAVIOR; FEMALE; LIPID METABOLISM; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; OLEIC ACIDS; POLYUNSATURATED ALKAMIDES; PPAR GAMMA; QUANTITATIVE TRAIT LOCI; SIGNAL TRANSDUCTION;

EID: 84859389098     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M020966     Document Type: Article

References (35)

1. Foster-Schubert, K. E., and D. E. Cummings. 2006. Emerging therapeutic strategies for obesity. Endocr. Rev. 27: 779-793. (Pubitemid 44936060)
2. Cao, H., K. Gerhold, J. R. Mayers, M. M. Wiest, S. M. Watkins, and G. S. Hotamisligil. 2008. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell. 134: 933-944.
3. Gillum, M. P., D. Zhang, X. M. Zhang, D. M. Erion, R. A. Jamison, C. Choi, J. Dong, M. Shanabrough, H. R. Duenas, D. W. Frederick, et al. 2008. N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake. Cell. 135: 813-824.
4. Schwartz, G. J., J. Fu, G. Astarita, X. Li, S. Gaetani, P. Campolongo, V. Cuomo, and D. Piomelli. 2008. The lipid messenger OEA links dietary fat intake to satiety. Cell Metab. 8: 281-288.
5. Fu, J., S. Gaetani, F. Oveisi, J. Lo Verme, A. Serrano, F. Rodriguez De Fonseca, A. Rosengarth, H. Luecke, B. Di Giacomo, G. Tarzia, et al. 2003. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature. 425: 90-93. (Pubitemid 37101723)
6. Capasso, R., and A. A. Izzo. 2008. Gastrointestinal regulation of food intake: general aspects and focus on anandamide and oleoylethanolamide. J. Neuroendocrinol. 20 (Suppl. 1): 39-46. (Pubitemid 351552675)
7. Hansen, H. S., and T. A. Diep. 2009. N-acylethanolamines, anandamide and food intake. Biochem. Pharmacol. 78: 553-560.
8. Fu, J., G. Astarita, S. Gaetani, J. Kim, B. F. Cravatt, K. Mackie, and D. Piomelli. 2007. Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine. J. Biol. Chem. 282: 1518-1528. (Pubitemid 47076553)
9. Fu, J., J. Kim, F. Oveisi, G. Astarita, and D. Piomelli. 2008. Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295: R45-R50.
10. Fu, J., F. Oveisi, S. Gaetani, E. Lin, and D. Piomelli. 2005. Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats. Neuropharmacology. 48: 1147-1153. (Pubitemid 40725987)
11. Osei-Hyiaman, D., M. DePetrillo, P. Pacher, J. Liu, S. Radaeva, S. Batkai, J. Harvey-White, K. Mackie, L. Offertaler, L. Wang, et al. 2005. Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J. Clin. Invest. 115: 1298-1305. (Pubitemid 40629049)
12. Siegmund, S. V., E. Seki, Y. Osawa, H. Uchinami, B. F. Cravatt, and R. F. Schwabe. 2006. Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. J. Biol. Chem. 281: 10431-10438. (Pubitemid 43864582)
13. Kaczocha, M., S. T. Glaser, and D. G. Deutsch. 2009. Identification of intracellular carriers for the endocannabinoid anandamide. Proc. Natl. Acad. Sci. USA. 106: 6375-6380.
14. Storch, J., and A. E. Thumser. 2010. Tissue-specific functions in the fatty acid-binding protein family. J. Biol. Chem. 285: 32679-32683.
15. Newberry, E. P., S. M. Kennedy, Y. Xie, B. T. Sternard, J. Luo, and N. O. Davidson. 2008. Diet-induced obesity and hepatic steatosis in L-Fabp-/- mice is abrogated with SF, but not PUFA, feeding and attenuated after cholesterol supplementation. Am. J. Physiol. Gastrointest. Liver Physiol. 294: G307-G314.
16. Newberry, E. P., Y. Xie, S. Kennedy, X. Han, K. K. Buhman, J. Luo, R. W. Gross, and N. O. Davidson. 2003. Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene. J. Biol. Chem. 278: 51664-51672. (Pubitemid 38020412)
17. Newberry, E. P., Y. Xie, S. M. Kennedy, J. Luo, and N. O. Davidson. 2006. Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Hepatology. 44: 1191-1205. (Pubitemid 44748370)
18. Lagakos, W. S., A. M. Gajda, L. Agellon, B. Binas, V. Choi, B. Mandap, T. Russnak, Y. X. Zhou, and J. Storch. 2011. Different functions of intestinal and liver-type fatty acid-binding proteins in intestine and in whole body energy homeostasis. Am. J. Physiol. Gastrointest. Liver Physiol. 300: G803-G814.
19. Martin, G. G., B. P. Atshaves, A. L. McIntosh, J. T. Mackie, A. B. Kier, and F. Schroeder. 2008. Liver fatty acid-binding protein gene-ablated female mice exhibit increased age-dependent obesity. J. Nutr. 138: 1859-1865.
20. Newberry, E. P., S. M. Kennedy, Y. Xie, J. Luo, and N. O. Davidson. 2009. Diet-induced alterations in intestinal and extrahepatic lipid metabolism in liver fatty acid binding protein knockout mice. Mol. Cell. Biochem. 326: 79-86.
21. Millar, J. S., D. A. Cromley, M. G. McCoy, D. J. Rader, and J. T. Billheimer. 2005. Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339. J. Lipid Res. 46: 2023-2028. (Pubitemid 41248500)
22. Astarita, G., B. Di Giacomo, S. Gaetani, F. Oveisi, T. R. Compton, S. Rivara, G. Tarzia, M. Mor, and D. Piomelli. 2006. Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties. J. Pharmacol. Exp. Ther. 318: 563-570. (Pubitemid 44061230)
23. Newberry, E. P., S. M. Kennedy, Y. Xie, J. Luo, S. E. Stanley, C. F. Semenkovich, R. M. Crooke, M. J. Graham, and N. O. Davidson. 2008. Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models. Hepatology. 48: 1097-1105.
24. Ellacott, K. L., G. J. Morton, S. C. Woods, P. Tso, and M. W. Schwartz. 2010. Assessment of feeding behavior in laboratory mice. Cell Metab. 12: 10-17.
25. Galarce, E. M., and P. C. Holland. 2009. Effects of cues associated with meal interruption on feeding behavior. Appetite. 52: 693-702.
26. Motter, A. L., and G. P. Ahern. 2008. TRPV1-null mice are protected from diet-induced obesity. FEBS Lett. 582: 2257-2262.
27. Atshaves, B. P., A. L. McIntosh, S. M. Storey, K. K. Landrock, A. B. Kier, and F. Schroeder. 2010. High dietary fat exacerbates weight gain and obesity in female liver fatty acid binding protein gene-ablated mice. Lipids. 45: 97-110.
28. Arsov, T., C. Z. Larter, C. J. Nolan, N. Petrovsky, C. C. Goodnow, N. C. Teoh, M. M. Yeh, and G. C. Farrell. 2006. Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. Biochem. Biophys. Res. Commun. 342: 1152-1159.
29. Arsov, T., D. G. Silva, M. K. O'Bryan, A. Sainsbury, N. J. Lee, C. Kennedy, S. S. Manji, K. Nelms, C. Liu, C. G. Vinuesa, et al. 2006. Fat aussie - a new Alstrom syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis. Mol. Endocrinol. 20: 1610-1622. (Pubitemid 43967568)
30. Collin, G. B., E. Cyr, R. Bronson, J. D. Marshall, E. J. Gifford, W. Hicks, S. A. Murray, Q. Y. Zheng, R. S. Smith, P. M. Nishina, et al. 2005. Alms1-disrupted mice recapitulate human Alstrom syndrome. Hum. Mol. Genet. 14: 2323-2333. (Pubitemid 41417995)
31. Moise, A. R., G. P. Lobo, B. Erokwu, D. L. Wilson, D. Peck, S. Alvarez, M. Dominguez, R. Alvarez, C. A. Flask, A. R. de Lera, et al. 2010. Increased adiposity in the retinol saturase-knockout mouse. FASEB J. 24: 1261-1270.
32. Schupp, M., M. I. Lefterova, J. Janke, K. Leitner, A. G. Cristancho, S. E. Mullican, M. Qatanani, N. Szwergold, D. J. Steger, J. C. Curtin, et al. 2009. Retinol saturase promotes adipogenesis and is down-regulated in obesity. Proc. Natl. Acad. Sci. USA. 106: 1105-1110.
33. Verkman, A. S. 2009. Knock-out models reveal new aquaporin functions. Handb. Exp. Pharmacol. 2009: 359-381.
34. Duffy, P. H., R. J. Feuers, and R. W. Hart. 1990. Effect of chronic caloric restriction on the circadian regulation of physiological and behavioral variables in old male B6C3F1 mice. Chronobiol. Int. 7: 291-303.
35. Touriño, C., F. Oveisi, J. Lockney, D. Piomelli, and R. Maldonado. 2010. FAAH deficiency promotes energy storage and enhances the motivation for food. Int. J. Obes. (Lond.). 34: 557-568.