Inhibition of Pim1 kinase activation attenuates allergen-induced airway hyperresponsiveness and inflammation

American Journal of Respiratory Cell and Molecular Biology

Volumn 46, Issue 4, 2012, Pages 488-497

  Shin, Yoo Seob ^a   Takeda, Katsuyuki ^a   Shiraishi, Yoshiki ^a   Jia, Yi ^a   Wang, Meiqin ^a   Jackson, Leila ^b   Wright, A Dale ^b   Carter, Laura ^b   Robinson, John ^b   Hicken, Erik ^b   Gelfand, Erwin W ^a  

^a DEPARTMENT OF MEDICINE   (United States)

^b ARRAY BIOPHARMA INC   (United States)

Author keywords

Airway hyperresponsiveness; Inflammation; Pim1 kinase; T cells

Indexed keywords

ALLERGEN; ANTIGEN; AR 00460770; CYTOKINE; METHACHOLINE; OVALBUMIN; PROTEIN KINASE PIM 1; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COMPOSITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME INHIBITION; EOSINOPHIL; FEMALE; GOBLET CELL; HUMAN; HUMAN CELL; METAPLASIA; MOUSE; NONHUMAN; PNEUMONIA; PROTEIN FUNCTION; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; SENSITIZATION; TH2 CELL;

ALLERGENS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; GOBLET CELLS; HYPERSENSITIVITY; INFLAMMATION; LUNG; METHACHOLINE CHLORIDE; MICE; MICE, INBRED BALB C; OVALBUMIN; PNEUMONIA; PROTO-ONCOGENE PROTEINS C-PIM-1; RESPIRATORY HYPERSENSITIVITY;

MUS;

EID: 84859375843     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2011-0190OC     Document Type: Article

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