Elevated serum interferon-γ in atopic asthma correlates with increased airways responsiveness and circadian peak expiratory flow variation

European Respiratory Journal

Volumn 11, Issue 2, 1998, Pages 312-316

  Ten Hacken, N H T ^a   Oosterhoff, Y ^a   Kauffman, H F ^a   Guevarra, L ^b   Satoh, T ^b   Tollerud, D J ^b   Postma, D S ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Airways; Asthma; Responsiveness; Serum interferon

Indexed keywords

GAMMA INTERFERON;

AIRWAY OBSTRUCTION; ALLERGIC ASTHMA; ARTICLE; ASTHMA; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FORCED EXPIRATORY VOLUME; HUMAN; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CIRCADIAN RHYTHM; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; HYPERSENSITIVITY; INTERFERON TYPE II; INTERLEUKIN-4; INTERLEUKIN-5; MALE; PEAK EXPIRATORY FLOW RATE; RESPIRATORY HYPERSENSITIVITY;

EID: 0031911281     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.98.11020312     Document Type: Article

References (17)

1. Oosterhoff Y, Hoogsteden HC, Rutgers B, Kauffman HF, Postma DS. Lymphocyte and macrophage activation in bronchoalveolar lavage fluid in nocturnal asthma. Am J Respir Crit Care Med 1995; 151: 75-81.
2. Kay AB. T lymphocytes and their products in atopic allergy and asthma. Int Arch Allergy Appl Immunol 1991; 94: 189-193.
3. Matsumoto T, Miike T, Yamaguchi K, Murakami M, Kawabe T, Yodoi J. Serum levels of soluble IL-2 receptor, IL-4 and IgE-binding factors in childhood allergic diseases. Clin Exp Immunol 1991; 85: 288-292.
4. Hashimoto S, Amemiya E, Tomita Y, et al. Elevation of soluble IL-2 receptor and IL-4, and nonelevation of IFN-gamma in sera from patients with allergic asthma. Ann Allergy 1993; 71: 455-458.
5. Matsumoto K, Taki F, Miura M, Matsuzaki M, Takagi K. Serum levels of soluble IL-2R, IL-4, and soluble Fc epsilon RII in adult bronchial asthma. Chest 1994; 105: 681-686.
6. Tang ML, Coleman J, Kemp AS. Interleukin-4 and interferon-gamma production in atopic and non-atopic children with asthma. Clin Exp Allergy 1995; 25: 515-521.
7. Corrigan CJ, Kay AB. CD4 T-lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status. Am Rev Respir Dis 1990; 141: 970-977.
8. 4 production by gamma interferon in leukocytes challenged with an allergen. Int Arch Allergy Appl Immunol 1988; 87: 286-293.
9. Brand PLP, Kerstjens HAM, Kauffman HF, De Monchy JGR, and the Dutch CNSLD Study Group. Interpretation of skin tests to house dust mite and relationship to other allergy parameters in patients with asthma and COPD. J Allergy Clin Immunol 1993; 91: 560-570.
10. Rijcken B, Schouten JP, Weiss ST, Speizer FE, Van der Lende R. The relationship of nonspecific bronchial responsiveness to respiratory symptoms in a random population sample. Am Rev Respir Dis 1987; 136: 62-68.
11. Oosterhoff Y, Koëter GH, De Monchy JGR, Postma DS. Circadian variation in airway responsiveness to methacholine, propranolol and AMP in atopic asthmatic subjects. Am Rev Respir Dis 1993; 147: 351-357.
12. Hessel EM, Van Oosterhout AJM, Van Ark I, et al. Development of airway hyperresponsiveness is dependent on interferon-γ and independent of eosinophil infiltration. Am J Respir Cell Mol Biol 1997; 16: 325-334.
13. Broide DH, Lotz M, Cuomo AJ, Coburn DA, Federman EC, Wasserman SI. Cytokines in symptomatic asthma airways. J Allergy Clin Immunol 1992; 89: 958-967.
14. Sousa AR, Poston RN, Lane SJ, Nakhosteen JA, Lee TH. Detection of GM-CSF in asthmatic bronchial epithelium and decrease by inhaled corticosteroids. Am Rev Respir Dis 1993; 147: 1557-1561.
15. Krug N, Madden J, Redington AK, et al. T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol 1996; 14: 319-326.
16. Ying S, Durham SR, Corrigan CJB, Hamid Q, Kay AB. Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon γ) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal subjects. Am J Respir Cell Mol Biol 1995; 12: 477-487.
17. Postma DS, Oosterhoff Y, Van Aalderen WMC, Kauffman HF, Wempe JB, Koëter GH. Inflammation in nocturnal asthma? Am J Respir Crit Care Med 1994; 150: 583-586.