Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils

Journal of Allergy and Clinical Immunology

Volumn 123, Issue 3, 2009, Pages 603-611

  Andina, Nicola ^a   Didichenko, Svetlana ^a   Schmidt Mende, Jan ^a   Dahinden, Clemens A ^a   Simon, Hans Uwe ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Apoptosis; eosinophils; IL 5; inflammation; phosphatidylinositol 3 kinase; proviral integration site for Moloney murine leukemia virus

Indexed keywords

2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; 2 MORPHOLINO 8 PHENYLCHROMONE; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; INTERLEUKIN 5; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE PIM 1; PROTEIN MCL 1; SD 1029; STAT5 PROTEIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; VIRUS FUSION PROTEIN; WORTMANNIN;

APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; EOSINOPHIL; EOSINOPHILIA; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOSTIMULATION; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; VIRUS EXPRESSION; WILD TYPE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENINE; ANDROSTADIENES; APOPTOSIS; CELLS, CULTURED; CHROMONES; EOSINOPHILS; HUMANS; HYPERSENSITIVITY; INTERLEUKIN-5; JANUS KINASE 2; MICROSCOPY, CONFOCAL; MORPHOLINES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-PIM-1; QUINAZOLINES; TYRPHOSTINS; XANTHENES;

EID: 61549096257     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2008.12.004     Document Type: Article

References (51)

1. Simon D., and Simon H.U. Eosinophilic disorders. J Allergy Clin Immunol 119 (2007) 1291-1300
2. Simon H.U. Regulation of eosinophil and neutrophil apoptosis-similarities and differences. Immunol Rev 179 (2001) 156-162
3. Rothenberg M. Eosinophilia. N Engl J Med 338 (1998) 1592-1600
4. Pope S.M., Zimmermann N., Stringer K.F., Karow M.L., and Rothenberg M.E. The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia. J Immunol 175 (2005) 5341-5350
5. Simon H.U., Yousefi S., Schranz C., Schapowal A., Bachert C., and Blaser K. Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J Immunol 158 (1997) 3902-3908
6. Yousefi S., Hoessli D.C., Blaser K., Mills G.B., and Simon H.U. Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils. J Exp Med 183 (1996) 1407-1414
7. Pazdrak K., Olszewska-Pazdrak B., Stafford S., Garofalo R.P., and Alam R. Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin-5, whereas only Raf-1 kinase is critical for eosinophil activation and degranulation. J Exp Med 188 (1998) 421-429
8. Simon H.U., Yousefi S., Dibbert B., Levi-Schaffer F., and Blaser K. Anti-apoptotic signals of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophils. Eur J Immunol 27 (1997) 3536-3539
9. Rosas M., Dijkers P.F., Lindemans C.L., Lammers J.W., Koenderman L., and Coffer P.J. IL-5-mediated eosinophil survival requires inhibition of GSK-3 and correlates with beta-catenin relocalization. J Leukoc Biol 80 (2006) 186-195
10. Miike S., Nakao A., Hiraguri M., Kurasawa K., Saito Y., and Iwamoto I. Involvement of Jak2, but not PI3-kinase/Akt and MAP kinase pathways, in anti-apoptotic signals of GM-CSF in human eosinophils. J Leukoc Biol 65 (1999) 700-706
11. Amaravadi R., and Thompson C.B. The survival kinases Akt and Pim as potential pharmacological targets. J Clin Invest 115 (2005) 2618-2624
12. Mikkers H., Allen J., Knipscheer P., Romeyn L., Hart A., Vink E., et al. High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat Genet 32 (2002) 153-159
13. Bachmann M., and Möröy T. The serine/threonine kinase Pim-1. Int J Biochem Cell Biol 37 (2005) 726-730
14. Fox C.J., Hammerman P.S., and Thompson C.B. The Pim kinases control rapamycin-resistant T cell survival and activation. J Exp Med 201 (2005) 259-266
15. Temple R., Allen E., Fordham J., Phipps S., Schneider H.C., Lindauer K., et al. Microarray analysis of eosinophils reveals a number of candidate survival and apoptosis genes. Am J Respir Cell Mol Biol 25 (2001) 425-433
16. Bates M.E., Liu L.Y., Esnault S.E., Stout B.A., Fonkem E., Kung V., et al. Expression of interleukin-5- and granulocyte macrophage-colony-stimulating factor-responsive genes in blood and airway eosinophils. Am J Respir Cell Mol Biol 30 (2004) 736-743
17. Stout B.A., Bates M.E., Liu L.Y., Farrington N.N., and Bertics P.J. IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils. J Immunol 173 (2004) 6409-6417
18. Simon H.U., Weber M., Becker E., Zilberman Y., Blaser K., and Levi-Schaffer F. Eosinophils maintain their capacity to signal and release eosinophil cationic protein upon repetitive stimulation with the same agonist. J Immunol 165 (2000) 4069-4075
19. Conus S., Bruno A., and Simon H.U. Leptin is an eosinophil survival factor. J Allergy Clin Immunol 116 (2005) 1228-1234
20. Simon H.U., Plötz S., Simon D., Seitzer U., Braathen L.R., Menz G., et al. Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome. Eur J Immunol 33 (2003) 834-839
21. Vassina E.M., Yousefi S., Simon D., Zwicky C., Conus S., and Simon H.U. cIAP-2 and survivin contribute to cytokine-mediated delayed eosinophil apoptosis. Eur J Immunol 36 (2006) 1975-1984
22. von Gunten S., Vogel M., Schaub A., Stadler B.M., Miescher S., Crocker P.R., et al. Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies. J Allergy Clin Immunol 119 (2007) 1005-1011
23. Conus S., Perozzo R., Reinheckel T., Peters C., Scapozza L., Yousefi S., et al. Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation. J Exp Med 205 (2008) 685-698
24. Yousefi S., Gold J.A., Andina N., Lee J.J., Kelly A.M., Kozlowski E., et al. Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat Med 14 (2008) 949-953
25. Chaussade C., Rewcastle G.W., Kendall J.D., Denny W.A., Cho K., Gronning L.M., et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J 404 (2007) 449-458
26. Jacobs M.D., Black J., Futer O., Swenson L., Hare B., Fleming M., et al. Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002. J Biol Chem 280 (2005) 13728-13734
27. Duan Z., Bradner J.E., Greenberg E., Levine R., Foster R., Mahoney J., et al. SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation. Clin Cancer Res 12 (2006) 6844-6852
28. Saris C.J., Domen J., and Berns A. The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG. EMBO J 10 (1991) 655-664
29. Fawell S., Seery J., Daikh Y., Moore C., Chen L.L., Pepinsky B., et al. Tat-mediated delivery of heterologous proteins into cells. Proc Natl Acad Sci U S A 91 (1994) 664-668
30. Dzhagalov I., St John A., and He Y.W. The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. Blood 109 (2007) 1620-1626
31. Edwards S.W., Derouet M., Howse M., and Moots R.J. Regulation of neutrophil apoptosis by Mcl-1. Biochem Soc Trans 32 (2004) 489-492
32. Druilhe A., Arock M., Le Goff L., and Pretolani M. Human eosinophils express bcl-2 family proteins: modulation of Mcl-1 expression by IFN-gamma. Am J Respir Cell Mol Biol 18 (1998) 315-322
33. Simon D., Braathen L.R., and Simon H.U. Anti-interleukin-5 antibody therapy in eosinophilic diseases. Pathobiology 72 (2005) 287-292
34. Plötz S.G., Simon H.U., Darsow U., Simon D., Vassina E., Yousefi S., et al. Use of an anti-interleukin-5 antibody in the hypereosinophilic syndrome with eosinophilic dermatitis. N Engl J Med 349 (2003) 2334-2339
35. Gevaert P., Lang-Loidolt D., Lackner A., Stammberger H., Staudinger H., Van Zele T., et al. Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps. J Allergy Clin Immunol 118 (2006) 1133-1141
36. Stein M.L., Collins M.H., Villanueva J.M., Kushner J.P., Putnam P.E., Buckmeier B.K., et al. Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis. J Allergy Clin Immunol 118 (2006) 1312-1319
37. Rothenberg M.E., Klion A.D., Roufosse F.E., Kahn J.E., Weller P.F., Simon H.U., et al. Treatment of patients with the hypereosinophilic syndrome with mepolizumab. N Engl J Med 358 (2008) 1215-1228
38. Adachi T., Hanaka S., Masuda T., Yoshihara H., Nagase H., and Ohta K. Transduction of phosphatase and tensin homolog deleted on chromosome 10 into eosinophils attenuates survival, chemotaxis, and airway inflammation. J Immunol 179 (2007) 8105-8111
39. Cowburn A.S., Cadwallader K.A., Reed B.J., Farahi N., and Chilvers E.R. Role of PI3-kinase-dependent Bad phosphorylation and altered transcription in cytokine-mediated neutrophil survival. Blood 100 (2002) 2607-2616
40. Gardai S.J., Hildeman D.A., Frankel S.K., Whitlock B.B., Frasch S.C., Borregaard N., et al. Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem 279 (2004) 21085-21095
41. Martinelli S., Kostylina G., Niggli V., Baumann C., Fey M.F., Wendel H.G., et al. Targeting survivin via PI3K but not c-akt/PKB by anticancer drugs in immature neutrophils. Oncogene 25 (2006) 6915-6923
42. Gazit A., Osherov N., Posner I., Yaish P., Poradosu E., Gilon C., et al. Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J Med Chem 34 (1991) 1896-1907
43. Kirken R.A., Erwin R.A., Taub D., Murphy W.J., Behbod F., Wang L., et al. Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells. J Leukoc Biol 65 (1999) 891-899
44. Burgel P.R., Escudier E., Coste A., Dao-Pick T., Ueki I.F., Takeyama K., et al. Regulation of epidermal growth factor receptor expression to goblet cell hyperplasia in nasal polyps. J Allergy Clin Immunol 106 (2000) 705-712
45. Leonard W.J., and O'Shea JJ. Jaks and STATs: biological implications. Annu Rev Immunol 16 (1998) 293-322
46. Mui A.L., Wakao H., Kinoshita T., Kitamura T., and Miyajima A. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. EMBO J 15 (1996) 2425-2433
47. Dibbert B., Daigle I., Braun D., Schranz C., Weber M., Blaser K., et al. Role for Bcl-xL in delayed eosinophil apoptosis mediated by granulocyte-macrophage colony-stimulating factor and interleukin-5. Blood 92 (1998) 778-783
48. Simon H.U. Molecules involved in the regulation of eosinophil apoptosis. Chem Immunol Allergy 91 (2006) 49-58
49. Hall D.J., Cui J., Bates M.E., Stout B.A., Koenderman L., Coffer P.J., et al. Transduction of a dominant-negative H-Ras into human eosinophils attenuates extracellular signal-regulated kinase activation and interleukin-5-mediated cell viability. Blood 98 (2001) 2014-2021
50. Verploegen S., Ulfman L., van Deutekom H.W.M., van Aalst C., Honing H., Lammers J.W.J., et al. Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function. Blood 106 (2005) 1076-1083
51. Danner R.L., Joiner K.A., Rubin M., Patterson W.H., Johnson N., Ayers K.M., et al. Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide. Antimicrob Agents Chemother 33 (1989) 1428-1434