Sox4 functions as a positive regulator of β-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas

Laboratory Investigation

Volumn 92, Issue 4, 2012, Pages 511-521

  Saegusa, Makoto ^a   Hashimura, Miki ^a   Kuwata, Takeshi ^b  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

Author keywords

catenin; endometrial carcinoma; p21 WAF1; Sox; TCF4

Indexed keywords

BETA CATENIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR SOX4; TUMOR PROMOTER;

ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; DNA METHYLATION; ENDOMETRIUM CARCINOMA; FEEDBACK SYSTEM; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; GENETIC ASSOCIATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREACTIVITY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR DIFFERENTIATION; UPREGULATION;

ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BETA CATENIN; CARCINOMA, ENDOMETRIOID; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; DNA METHYLATION; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MORULA; PROMOTER REGIONS, GENETIC; SOXC TRANSCRIPTION FACTORS; SOXF TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84859369866     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2011.196     Document Type: Article

References (36)

1. Schepers GE, Teasdale RD, Koopman P. Twenty pairs of Sox: extent, homology, and nomenclature of the mouse and human Sox transcription factor gene families. Dev Cell 2002;3:167-170.
2. Lefebvre V, Dumitriu B, Penzo-Mendez A, et al. Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors. Int J Biochem Cell Biol 2007;39:2195-2214. (Pubitemid 47484275)
3. Dy P, Penzo-Mendez A, Wang H, et al. The three SoxC proteins-Sox4, Sox11 and Sox12-exhibit overlapping expression patterns and molecular properties. Nucleic Acids Res 2008;36:3101-3117. (Pubitemid 351737202)
4. Bowles J, Schepers G, Koopman P. Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev Biol 2000;227:239-255.
5. Kiefer JC. Back to basics: Sox genes. Dev Dyn 2007;236:2356-2366.
6. Harley VR, Lovell-Badge R, Goodfellow PN. Definition of a consensus DNA binding site for SRY. Nucleic Acids Res 1994;22:1500-1501. (Pubitemid 24166854)
7. Grosschedl R, Giese K, Pagel J. HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. Trends Genet 1994;10:94-100. (Pubitemid 24075089)
8. Penzo-Mendez AI. Critical roles for SoxC transcription factors in development and cancer. Int J Biochem Cell Biol 2010;42:425-428.
9. Graham JD, Hunt SMN, Tran N, et al. Regulation of the expression and activity by progestins of a member of the SOX gene family of transcriptional modulators. J Mol Endocrinol 1999;22:295-304. (Pubitemid 29281838)
10. Hunt SMN, Clarke CL. Expression and hormonal regulation of the Sox4 gene in mouse female reproductive tissues. Biol Reprod 1999;61: 476-481. (Pubitemid 29344767)
11. Lee CJ, Appleby VJ, Orme AT, et al. Differential expression of SOX4 and SOX11 in medulloblastomas. J Neurooncol 2002;57:201.
12. Aaboe M, Birkenkamp-Demtroder K, Wiuf C, et al. SOX4 expression in bladder carcinoma: clinical aspects and in vitro functional characterization. Cancer Res 2006;66:3434-3442.
13. Rhodes DR, Yu J, Shanker K, et al. Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc Natl Acad Sci USA 2004;101:9309-9314. (Pubitemid 38812872)
14. Zaino RJ, Kurman R, Herbold D, et al. The significance of squamous differentiation in endometrial carcinoma: data from Gynecologic Oncology Group Study. Cancer 1991;68:2293-2302.
15. Buckey CH. Normal endometrium and non-proliferative conditions of the endometrium. In: Fox H, Wells M (eds). Haines and Taylor Obstetrical and Gynaecological Pathology, 5th edn. Churchill Livingstone: London, 2003, pp 391-441.
16. Brachtel EF, Sanchez-Estevez C, Moreno-Bueno G, et al. Distinct molecular alterations in complex endometrial hyperplasia (CEH) with and without immature squamous metaplasia (squamous morules). Am J Surg Pathol 2005;29:1322-1329. (Pubitemid 41368768)
17. Saegusa M, Hashimura M, Kuwata T, et al. β-Catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells. Am J Pathol 2004;164:1739-1749. (Pubitemid 38529776)
18. Saegusa M, Hashimura M, Kuwata T, et al. Upregulation of TCF4 expression as a transcriptional target of β-catenin/p300 complexes during trans-differentiation of endometrial carcinoma cells. Lab Invest 2005;85:768-779. (Pubitemid 40799706)
19. Saegusa M, Hashimura M, Kuwata T, et al. Transcription factor Egr1 acts as an upstream regulator of β-catenin signaling through up-regulation of TCF4 and p300 expression during trans- differentiation of endometrial carcinoma cells. J Pathol 2008;216:521-532.
20. Saegusa M, Hashimura M, Kuwata T. Pin1 acts as a modulator of cell proliferation through alteration in NF-κB but not β-catenin/TCF4 signaling in a subset of endometrial carcinoma cells. J Pathol 2010;222:410-420.
21. Sinner D, Kordich JJ, Spence JR, et al. Sox17 and Sox4 differentially regulate β-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol Cell Biol 2007;27:7802-7815. (Pubitemid 350086414)
22. Ke S-H, Madison EL. Rapid and efficient site-directed mutagenesis by a single-tube 'megaprimer' PCR method. Nucleic Acids Res 1997;25:3371-3372. (Pubitemid 27338700)
23. Nishida M. Ishikawa cells: opening of in vitro hormone research on endometrial carcinoma. In: Kuramoto H, Nishida M (eds). Cell and Molecular Biology of Endometrial Carcinoma. Springer-Verlag: Tokyo, 2003, pp 35-60.
24. Kuramoto H, Hamano M, Imai M, et al. Hec-1 cells: establishment of an in vitro experimental system in endometrial carcinoma. In: Kuramoto H, Nishida M (eds). Cell and Molecular Biology of Endometrial Carcinoma. Tokyo: Springer-Verlag, 2003, pp 3-34.
25. Saegusa M, Hashimura M, Kuwata T, et al. Requirement of Akt/β-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of Slug. Am J Pathol 2009;174:2107-2115.
26. Silverberg SG, Mutter GL, Kurman RJ, et al. Tumours of the uterine corpus. Epithelial tumours and related lesions. In: Tavassoli FA, Devilee P (eds). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. IARC Press: Lyon, 2003, pp 221-232.
27. Creasman WT. Announcement FIGO stages: 1988 revisions. Gynecol Oncol 1989;35:125-127.
28. Mutter GL, Ferenczy A. Anatomy and histology of the uterine corpus. In: Kurman RJ (ed). Blaustein's Pathology of the Female Genital Tract, 5th edn. Springer-Verlag: New York, 2002, pp 383-419.
29. Guo L, Zhong D, Lau S, et al. Sox7 is an independent checkpoint for β-catenin function in prostate and colon epithelial cells. Mol Cancer Res 2008;6:1421-1430.
30. Zhang Y, Huang S, Dong W, et al. SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells. Cancer let 2009;277:29-37.
31. Moreno CS. The Sex-determining region Y-box 4 and homeobox C6 transcriptional networks in prostate cancer progression. Am J Pathol 2010;176:518-527.
32. Liu P, Ramachandran S, Seyed MA, et al. Sex-determining region Y box 4 is a transforming oncogene in human prostate cancer cells. Cancer Res 2006;66:4011-4019.
33. Hur W, Rhim H, Jung CK, et al. Sox4 overexpression regulates the p53-mediated apoptosis in hepatocellular carcinoma: clinical implication and functional analysis in vitro. Carcinogenesis 2010;31:1298-1307.
34. Kormish JD, Sinner D, Zorn AM. Interactions between Sox factors and Wnt/β-catenin signaling in development and disease. Dev Dyn 2010;239:56-68.
35. Lee A-K, Ahn S-G, Yoon J-H, et al. Sox4 stimulates β-catenin activity through induction of CK2. Oncol Rep 2010;25:559-565.
36. Lee E, Salic A, Kirschner MW. Physiological regulation of β-catenin stability by Tcf3 and CK1ε. J Cell Biol 2001;154:983-993. (Pubitemid 34286178)