Distinct molecular alterations in complex endometrial hyperplasia (CEH) with and without immature squamous metaplasia (squamous Morules)

American Journal of Surgical Pathology

Volumn 29, Issue 10, 2005, Pages 1322-1329

  Brachtel, Elena F ^a   Sánchez Estevez, Carolina ^b   Moreno Bueno, Gema ^b   Prat, Jaime ^c   Palacios, José ^b   Oliva, Esther ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Centro Nacional de Investigaciones Oncológicas   (Spain)

^c HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

Author keywords

catenin; Endometrial hyperplasia; Immature squamous metaplasia (squamous morules); K ras; Microsatellite instability; PTEN

Indexed keywords

BETA CATENIN; CYSTEINE; DNA; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ADULT; AGED; ARTICLE; CANCER GROWTH; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; ENDOMETRIOID CARCINOMA; ENDOMETRIUM BIOPSY; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; EXON; FEMALE; FOLLOW UP; GENE MUTATION; HUMAN; HUMAN TISSUE; HYSTERECTOMY; IMMUNOHISTOCHEMISTRY; MICROSATELLITE INSTABILITY; MOLECULAR GENETICS; MUTATIONAL ANALYSIS; ONCOGENE K RAS; OUTCOMES RESEARCH; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SALPINGOOOPHORECTOMY; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SQUAMOUS CELL METAPLASIA;

ADULT; AGED; BASE SEQUENCE; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; ENDOMETRIAL HYPERPLASIA; FEMALE; GENES, RAS; HUMANS; IMMUNOHISTOCHEMISTRY; METAPLASIA; MICROSATELLITE REPEATS; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; PRECANCEROUS CONDITIONS; UTERUS;

EID: 25444494429     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000171001.87599.e2     Document Type: Article

References (36)

1. Ashihara K, Saito T, Mizumoto H, et al. Loss of gamma-catenin expression in squamous differentiation in endometrial carcinomas. Int J Gynecol Pathol. 2002;21:246-254.
2. Ashihara K, Saito T, Mizumoto H, et al. Mutation of beta-catenin gene in endometrial cancer but not in associated hyperplasia. Med Electron Microsc. 2002;35:9-15.
3. Baloglu H, Cannizzaro LA, Jones J, et al. Atypical endometrial hyperplasia shares genomic abnormalities with endometrioid carcinoma by comparative genomic hybridization. Hum Pathol. 2001;32:615-622.
4. Bussaglia E, del Rio E, Matias-Guiu X, et al. Pten mutations in endometrial carcinomas: a molecular and clinicopathologic analysis of 38 cases. Hum Pathol. 2000;31:312-317.
5. Dahia PL, Marsh DJ, Zheng Z, et al. Somatic deletions and mutations in the cowden disease gene, pten, in sporadic thyroid tumors. Cancer Res. 1997;57:4710-4713.
6. Fukuchi T, Sakamoto M, Tsuda H, et al. Beta-catenin mutation in carcinoma of the uterine endometrium. Cancer Res. 1998;58:3526-3528.
7. Gamallo C, Palacios J, Moreno-Bueno G, et al. Beta-catenin expression pattern in stage I and II ovarian carcinomas: relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome. Am J Pathol. 1999;155:527-536.
8. Koul A, Willen R, Bendahl PO, et al. Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis. Cancer. 2002;94:2369-2379.
9. Lagarda H, Catasus L, Arguelles R, et al. K-ras mutations in endometrial carcinomas with microsatellite instability. J Pathol. 2001;193:193-199.
10. Lax SF. Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification. Virchows Arch. 2004;444:213-223.
11. Levine RL, Cargile CB, Blazes MS, et al. Pten mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma. Cancer Res. 1998;58:3254-3258.
12. Machin P, Catasus L, Pons C, et al. Ctnnb1 mutations and beta-catenin expression in endometrial carcinomas. Hum Pathol. 2002;33:206-212.
13. Matias-Guiu X, Catasus L, Bussaglia E, et al. Molecular pathology of endometrial hyperplasia and carcinoma. Hum Pathol. 2001;32:569-577.
14. Mirabelli-Primdahl L, Gryfe R, Kim H, et al. Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway. Cancer Res. 1999;59:3346-3351.
15. Moreno-Bueno G, Hardisson D, Sanchez-Estevez C, et al. Abnormalities of the apc/beta-catenin pathway in endometrial cancer. Oncogene. 2002;21:7981-7990.
16. Moreno-Bueno G, Hardisson D, Sarrio D, et al. Abnormalities of e- and p-cadherin and catenin (beta-, gamma-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia. J Pathol. 2003;199:471-478.
17. Moreno-Bueno G, Hardisson D, Prat J, et al. Nuclear beta-catenin is a molecular feature of type I endometrial carcinoma. J Pathol. 2004;202:511-512.
18. Morin PJ, Sparks AB, Korinek V, et al. Activation of beta-catenin-tcf signaling in colon cancer by mutations in beta-catenin or apc. Science. 1997;275:1787-1790.
19. Mutter GL. Pten, a protean tumor suppressor. Am J Pathol. 2001;158:1895-1898.
20. Oliva E, Brachtel EF, Soslow RA, et al. High frequency of beta-catenin nuclear expression and mutations in ovarian endometrioid tumors of borderline malignancy. Mod Pathol. 2004;17(suppl 1):209A.
21. Palacios J, Catasus L, Moreno-Bueno G, et al. Beta- and gamma-catenin expression in endometrial carcinoma: relationship with clinicopathological features and microsatellite instability. Virchows Arch. 2001;438:464-469.
22. Polakis P. Wnt signaling and cancer. Genes Dev. 2000;14:1837-1851.
23. Provost E, Yamamoto Y, Lizardi I, et al. Functional correlates of mutations in beta-catenin exon 3 phosphorylation sites. J Biol Chem. 2003;278:31781-31789.
24. Ronnett BM, Kurman RJ: Precursor lesions of endometrial carcinoma. In: Kurman, RJ, ed. Blaustein's Pathology of the Female Genital Tract. New York: Springer, 2002:467-500.
25. Rubinfeld B, Souza B, Albert I, et al. Association of the apc gene product with beta-catenin. Science. 1993;262:1731-1734.
26. Saegusa M, Hashimura M, Yoshida T, et al. Beta-catenin mutations and aberrant nuclear expression during endometrial tumorigenesis. Br J Cancer. 2001;84:209-217.
27. Saegusa M, Okayasu I. Frequent nuclear beta-catenin accumulation and associated mutations in endometrioid-type endometrial and ovarian carcinomas with squamous differentiation. J Pathol. 2001;194:59-67.
28. Saegusa M, Hashimura M, Kuwata T, et al. Beta-catenin simultaneously induces activation of the p53-p21waf1 pathway and overexpression of cyclin d1 during squamous differentiation of endometrial carcinoma cells. Am J Pathol. 2004;164:1739-1749.
29. Schlosshauer PW, Pirog EC, Levine RL, et al. Mutational analysis of the ctnnb1 and ape genes in uterine endometrioid carcinoma. Mod Pathol. 2000;13:1066-1071.
30. Scholten AN, Creutzberg CL, van den Broek LJ, et al. Nuclear beta-catenin is a molecular feature of type I endometrial carcinoma. J Pathol. 2003;201:460-465.
31. Sekine S, Shibata T, Kokubu A, et al. Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations. Am J Pathol. 2002;161:1997-2001.
32. Sekine S, Shibata T, Matsuno Y, et al. Beta-catenin mutations in pulmonary blastomas: association with morule formation. J Pathol. 2003;200:214-221.
33. Silverberg SG, Kurman RJ, Nogales F, et al. Tumors of the Uterine Corpus. In: Tavassoli FA, Devillee P, eds. Tumours of the Breast and Female Genital Organs. Lyon, France: IARC Press, 2003:221-230.
34. Su LK, Vogelstein B, Kinzler KW. Association of the ape tumor suppressor protein with catenins. Science. 1993;262:1734-1737.
35. Xu B, Yoshimoto K, Miyauchi A, et al. Cribriform-morular variant of papillary thyroid carcinoma: a pathological and molecular genetic study with evidence of frequent somatic mutations in exon 3 of the beta-catenin gene. J Pathol. 2003;199:58-67.
36. Zaino RJ, Kurman R, Herbold D, et al. The significance of squamous differentiation in endometrial carcinoma: data from a gynecologic oncology group study. Cancer. 1991;68:2293-2302.