Comparative analysis of mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  McEvoy, Christopher R E ^a,f   Cloete, Ruben ^a,g   Müller, Borna ^a   Schürch, Anita C ^b   van Helden, Paul D ^a   Gagneux, Sebastien ^c,d,e   Warren, Robin M ^a   Gey van Pittius, Nicolaas C ^a  

^a SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

^e NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^f UNIVERSITY OF MELBOURNE   (Australia)

^g UNIVERSITY OF THE WESTERN CAPE   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENIC VARIATION; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATION; COHORT ANALYSIS; CONTROLLED STUDY; GENE FREQUENCY; GENETIC VARIABILITY; MULTIGENE FAMILY; MUTATIONAL ANALYSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PE GENE; PHYLOGENY; PPE GENE; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; BACTERIAL GENOME; COMPARATIVE STUDY; DNA SEQUENCE; GENETIC SELECTION; GENETICS; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MOLECULAR EVOLUTION; PATHOGENICITY; TUBERCULOSIS;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS COMPLEX;

BACTERIAL ANTIGEN; BACTERIAL DNA; BACTERIAL PROTEIN;

ANTIGENIC VARIATION; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; COHORT STUDIES; DNA, BACTERIAL; EVOLUTION, MOLECULAR; GENES, BACTERIAL; GENETIC VARIATION; GENOME, BACTERIAL; HUMANS; MULTIGENE FAMILY; MYCOBACTERIUM TUBERCULOSIS; PHYLOGENY; SELECTION, GENETIC; SEQUENCE ANALYSIS, DNA; TUBERCULOSIS;

EID: 84859342693     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030593     Document Type: Article

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