The differential gene expression pattern of mycobacterium tuberculosis in response to capreomycin and PA-824 versus first-line TB drugs reveals stress- and PE/PPE-related drug targets

International Journal of Microbiology

Volumn , Issue , 2009, Pages

  Fu, Li M ^a   Tai, Shu C ^a  

^a Pac TB/Cancer Res Organization   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACILLI (CLASS); MYCOBACTERIUM TUBERCULOSIS;

EID: 77954221104     PISSN: 1687918X     EISSN: 16879198     Source Type: Journal    
DOI: 10.1155/2009/879621     Document Type: Article

References (33)

1. Y. Zhang and L. M. Amzel, "Tuberculosis drug targets, " Current Drug Targets, vol. 3, no. 2, pp. 131-154, 2002. (Pubitemid 34296204)
2. J. E. Gomez and J. D. McKinney, "M. tuberculosis persistence, latency, and drug tolerance, " Tuberculosis, vol. 84, no. 1-2, pp. 29-44, 2004. (Pubitemid 38082931)
3. L. G. Wayne and C. D. Sohaskey, "Nonreplicating persistence of Mycobacterium tuberculosis, " Annual Review of Microbiology, vol. 55, pp. 139-163, 2001. (Pubitemid 32978103)
4. H.M. Blumberg, M. K. Leonard Jr., and R. M. Jasmer, "Update on the treatment of tuberculosis and latent tuberculosis infection, " Journal of the American Medical Association, vol. 293, no. 22, pp. 2776-2784, 2005. (Pubitemid 40973380)
5. W. P. Gill, N. S. Harik, M. R.Whiddon, R. P. Liao, J. E.Mittler, and D. R. Sherman, "A replication clock for Mycobacterium tuberculosis, " Nature Medicine, vol. 15, no. 2, pp. 211-214, 2009.
6. R. M. McCune Jr. and R. Tompsett, "Fate of Mycobacterium tuberculosis in mouse tissues as determined by the microbial enumeration technique-I: the persistence of drugsusceptible tubercle bacilli in the tissues despite prolonged antimicrobial therapy, " The Journal of Experimental Medicine, vol. 104, no. 5, pp. 737-762, 1956.
7. M. Zierski, "Capreomycin and other drugs in the treatment of pulmonary tuberculosis, " Tubercle, vol. 50, supplement, pp. 37-39, 1969.
8. N. Rastogi, V. Labrousse, and K. S. Goh, "In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages, " Current Microbiology, vol. 33, no. 3, pp. 167-175, 1996. (Pubitemid 26272372)
9. L. Heifets, J. Simon, and V. Pham, "Capreomycin is active against non-replicating M. tuberculosis, " Annals of Clinical Microbiology and Antimicrobials, vol. 4, no. 1, p. 6, 2005.
10. C. K. Stover, P. Warrener, D. R. VanDevanter, et al., "A smallmolecule nitroimidazopyran drug candidate for the treatment of tuberculosis, " Nature, vol. 405, no. 6789, pp. 962-966, 2000. (Pubitemid 30435054)
11. Y.Hu, A. R. M. Coates, and D. A. Mitchison, "Comparison of the sterilising activities of the nitroimidazopyran PA-824 and moxifloxacin against persisting Mycobacterium tuberculosis, " International Journal of Tuberculosis and Lung Disease, vol. 12, no. 1, pp. 69-73, 2008.
12. R. Tasneen, S. Tyagi, K. Williams, J. Grosset, and E. Nuermberger, "Enhanced bactericidal activity of rifampin and/or pyrazinamide when combined with PA-824 in a murine model of tuberculosis, " Antimicrobial Agents and Chemotherapy, vol. 52, no. 10, pp. 3664-3668, 2008.
13. C. E. Maus, B. B. Plikaytis, and T. M. Shinnick, "Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis, " Antimicrobial Agents and Chemotherapy, vol. 49, no. 2, pp. 571-577, 2005. (Pubitemid 40175664)
14. H. I. M. Boshoff, T. G. Myers, B. R. Copp, M. R.McNeil, M. A. Wilson, and C. E. Barry III, "The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action, " The Journal of Biological Chemistry, vol. 279, no. 38, pp. 40174-40184, 2004. (Pubitemid 39258293)
15. V. G. Tusher, R. Tibshirani, and G. Chu, "Significance analysis of microarrays applied to the ionizing radiation response, " Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 9, pp. 5116-5121, 2001. (Pubitemid 32397092)
16. S. Tavazoie, J. D. Hughes, M. J. Campbell, R. J. Cho, and G. M. Church, "Systematic determination of genetic network architecture, " Nature Genetics, vol. 22, no. 3, pp. 281-285, 1999. (Pubitemid 29297256)
17. M. Wilson, J. DeRisi, H.-H. Kristensen, et al., "Exploring drug-induced alterations in gene expression inMycobacterium tuberculosis by microarray hybridization, " Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 22, pp. 12833-12838, 1999. (Pubitemid 29513588)
18. L. M. Fu, "Exploring drug action on Mycobacterium tuberculosis using affymetrix oligonucleotide genechips, " Tuberculosis, vol. 86, no. 2, pp. 134-143, 2006. (Pubitemid 43227438)
19. J. Rengarajan, B. R. Bloom, and E. J. Rubin, "Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages, " Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 23, pp. 8327-8332, 2005. (Pubitemid 40800088)
20. J. C. Betts, P. T. Lukey, L. C. Robb, R. A. McAdam, and K. Duncan, "Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling, " Molecular Microbiology, vol. 43, no. 3, pp. 717-731, 2002. (Pubitemid 34597265)
21. G. R. Stewart, L. Wernisch, R. Stabler, et al., "Dissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays, " Microbiology, vol. 148, no. 10, pp. 3129-3138, 2002. (Pubitemid 35243712)
22. C. M. Sassetti, D. H. Boyd, and E. J. Rubin, "Genes required for mycobacterial growth defined by high density mutagenesis, " Molecular Microbiology, vol. 48, no. 1, pp. 77-84, 2003. (Pubitemid 36411469)
23. G. Fenhalls, L. Stevens, L. Moses, et al., "In situ detection of Mycobacterium tuberculosis transcripts in human lung granulomas reveals differential gene expression in necrotic lesions, " Infection and Immunity, vol. 70, no. 11, pp. 6330- 6338, 2002. (Pubitemid 35192725)
24. S. T. Cole, R. Brosch, J. Parkhill, et al., "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence, " Nature, vol. 393, no. 6685, pp. 537-544, 1998. (Pubitemid 28319235)
25. J.-M. Claverie, "Computational methods for the identification of differential and coordinated gene expression, " Human Molecular Genetics, vol. 8, no. 10, pp. 1821-1832, 1999. (Pubitemid 29458658)
26. P. Hieter and M. Boguski, "Functional genomics: It's all how you read it, " Science, vol. 278, no. 5338, pp. 601-602, 1997. (Pubitemid 27464949)
27. American Thoracic Society, "CDC, Infectious Diseases Society of America. Treatment of tuberculosis, " MMWR Recommendations and Reports, vol. 52, no. RR-11, pp. 1-77, 2003.
28. P. P. Cook, "Rifampin and pyrazinamide for treatment of latent tuberculosis infection, " Clinical Infectious Diseases, vol. 42, no. 6, p. 892, 2006. (Pubitemid 43363955)
29. D. Schnappinger, S. Ehrt, M. I. Voskuil, et al., "Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: insights into the phagosomal environment, " Journal of Experimental Medicine, vol. 198, no. 5, pp. 693-704, 2003. (Pubitemid 37087769)
30. L. M. Fu and T. M. Shinnick, "Genome-wide exploration of the drug action of capreomycin onMycobacterium tuberculosis using Affymetrix oligonucleotide GeneChips, " Journal of Infection, vol. 54, no. 3, pp. 277-284, 2007. (Pubitemid 46238171)
31. Y. Zhang, "The magic bullets and tuberculosis drug targets, " Annual Review of Pharmacology and Toxicology, vol. 45, pp. 529-564, 2005. (Pubitemid 40261816)
32. J. D. McKinney, K. Honer Zu Bentrup, E. J. Munoz-Elias, et al., "Persistence ofMycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase, " Nature, vol. 406, no. 6797, pp. 735-738, 2000.
33. D. R. Sherman, M. Voskuil, D. Schnappinger, R. Liao, M. I. Harrell, and G. K. Schoolnik, "Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding α-crystallin, " Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 13, pp. 7534-7539, 2001. (Pubitemid 32567983)