Effect of voriconazole and other azole antifungal agents on CYP3A activity and metabolism of tacrolimus in human liver microsomes

Xenobiotica

Volumn 42, Issue 5, 2012, Pages 409-416

  Zhang, Shimin ^a   Pillai, Venkateswaran C ^a   Mada, Sripal Reddy ^a   Strom, Steve ^b   Venkataramanan, Raman ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

human liver microsomes; metabolism; tacrolimus; Voriconazole

Indexed keywords

CYTOCHROME P450 3A; FLUCONAZOLE; ITRACONAZOLE; KETOCONAZOLE; TACROLIMUS; TESTOSTERONE; VORICONAZOLE;

ARTICLE; BLOOD; CONTROLLED STUDY; DRUG METABOLISM; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER METABOLISM; LIVER MICROSOME;

ADULT; AGED; ANTIFUNGAL AGENTS; CYTOCHROME P-450 CYP3A; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MALE; MICROSOMES, LIVER; PYRIMIDINES; SUBSTRATE SPECIFICITY; TACROLIMUS; TESTOSTERONE; TRIAZOLES;

EID: 84859313289     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.631224     Document Type: Article

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