Quercetin attenuates airway inflammation and mucus production induced by cigarette smoke in rats

International Immunopharmacology

Volumn 13, Issue 1, 2012, Pages 73-81

  Yang, Ting ^a   Luo, Feng ^a,b   Shen, Yongchun ^a   An, Jing ^a   Li, Xiaoou ^a   Liu, Xinyu ^a   Ying, Binwu ^a   Liao, Zenglin ^a   Dong, Jiajia ^a   Guo, Lingli ^a   Wang, Tao ^a   Xu, Dan ^a   Chen, Lei ^a   Wen, Fuqiang ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Inflammation; Mucin; Oxidative stress; Quercetin; Smoke

Indexed keywords

CIGARETTE SMOKE; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MUCIN 5AC; POLYSORBATE; QUERCETIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CELL COUNT; CELL HYPERPLASIA; CELL INFILTRATION; CELL LYSATE; CIGARETTE SMOKING; CONTROLLED STUDY; DRUG MEGADOSE; ENVIRONMENTAL EXPOSURE; GOBLET CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; LUNG LAVAGE; MALE; MUCUS SECRETION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOTTING, WESTERN; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; CELL LINE; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; HUMANS; MALE; MUCIN 5AC; OXIDATIVE STRESS; PNEUMONIA; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY MUCOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SMOKE; TOBACCO;

EID: 84859308891     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.03.006     Document Type: Article

References (31)

1. J.V. Fahy, and B.F. Dickey Airway mucus function and dysfunction N Engl J Med 363 23 2010 2233 2247
2. I. Cerveri, and V. Brusasco Revisited role for mucus hypersecretion in the pathogenesis of COPD Eur Respir Rev 19 116 2010 109 112
3. J.D. Taylor COPD and the response of the lung to tobacco smoke exposure Pulm Pharmacol Ther 23 5 2010 376 383
4. A.W. Boots, G.R. Haenen, and A. Bast Health effects of quercetin: from antioxidant to nutraceutical Eur J Pharmacol 585 2-3 2008 325 337
5. B. Ying, T. Yang, X. Song, X. Hu, H. Fan, and X. Lu Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways Mol Biol Rep 36 7 2009 1825 1832
6. S.H. Kwon, J.I. Nam, S.H. Kim, J.H. Kim, J.H. Yoon, and K.S. Kim Kaempferol and quercetin, essential ingredients in Ginkgo biloba extract, inhibit interleukin-1beta-induced MUC5AC gene expression in human airway epithelial cells Phytother Res 23 12 2009 1708 1712
7. S. Ganesan, A.N. Faris, A.T. Comstock, S.S. Chattoraj, A. Chattoraj, and J.R. Burgess Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression Respir Res 11 2010 131
8. Juliana Tieppo, María J. Cuevas, Rafael Vercelino, María J. Tuñón, Norma P. Marroni, and Javier González-Gallego Quercetin administration ameliorates pulmonary complications of cirrhosis in rats J Nutr 139 Jul 2009 1339 1346
9. L. Chen, B.-B. Sun, T. Wang, X. Wang, J.-Q. Li, and H.-X. Wang Cigarette smoke enhances {beta}-defensin 2 expression in rat airways via nuclear factor-{kappa}B activation Eur Respir J 36 3 2010 638 645
10. T. Wang, Y. Liu, L. Chen, X. Wang, X.-R. Hu, and Y.-L. Feng Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats Eur Respir J 33 2009 1122 1132
11. Xin J. Zhou, Nosratola D. Vaziri, Xiu Q. Wang, Fred G. Silva, and Zoltan Laszik Nitric oxide synthase expression in hypertension induced by inhibition of glutathione synthase J Pharmacol Exp Ther 300 2002 762
12. I.F. Benzie, and J.J. Strain The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay Anal Biochem 239 1 1996 70 76
13. E.G. Barrett, J.A. Wilder, T.H. March, T. Espindola, and D.E. Bice Cigarette smoke-induced airway hyperresponsiveness is not dependent on elevated immunoglobulin and eosinophilic inflammation in a mouse model of allergic airway disease Am J Respir Crit Care Med 165 2002 1410 1418
14. Jae-woong Hwang, Saravanan Rajendrasozhan, Hongwei Yao, Sangwoon Chung, Isaac K. Sundar, and Heidie L. Huyck FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease J Immunol 187 2011 987 998
15. Kiyoshi Takeyama, Karim Dabbagh, Jae Jeong Shim, Trang Dao-Pick, Iris F. Ueki, and Jay A. Nadel Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils J Immunol 164 2000 1546 1552
16. Seung Joon Kim, Chun Mi Kang, Moon Bin You, Hyung Kyu Yoon, Young Kyoon Kim, and Kwan Hyoung Kim IP-10 decreases TNF-α induced MUC5AC expression in human airway epithelial cells: a possible relation with little sputum production in idiopathic pulmonary fibrosis Tuberc Respir Dis 64 5 2008 347 355
17. Maria V. Bautista, Yajun Chen, Vessela S. Ivanova, Michael K. Rahimi, Alan M. Watson, and Mary C. Rose IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells J Immunol 183 2009 2159 2166
18. - cotransport via PTK-dependent mechanisms in human airway epithelium Am J Respir Cell Mol Biol 41 2009 688 695
19. S. Rohn, H.M. Rawel, and J. Kroll Antioxidant activity of protein-bound quercetin J Agric Food Chem 52 2004 4725 4729
20. E.V. Schmalhausen, E.B. Zhlobek, I.N. Shalova, O. Firuzi, L. Saso, and V.I. Muronetz Antioxidant and prooxidant effects of quercetin on glyceraldehyde-3-phosphate dehydrogenase Food Chem Toxicol 45 2007 1988 1993
21. M.E. Gerritsen, W.W. Carley, G.E. Ranges, C.P. Shen, S.A. Phan, and G.F. Ligon Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression Am J Pathol 147 1995 278 292
22. M.J. Alcaraz, M.J. Jimenez, S. Valverde, J. Sanz, R.M. Rabanal, and A. Villar Anti-inflammatory compounds from Sideritis javalambrensis n-hexane extract J Nat Prod 52 1989 1088 1091
23. V. Garcia-Mediavilla, I. Crespo, P.S. Collado, A. Esteller, S. Sanchez- Campos, and M.J. Tunon The antiinflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor-kappa B pathway in Chang liver cells Eur J Pharmacol 557 2007 221 229
24. M.A. Avila, J.A. Velasco, J. Cansado, and V. Notario Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468 Cancer Res 54 1994 2424 2428
25. W. Krol, S. Dworniczak, G. Pietsz, Z.P. Czuba, M. Kunicka, and M. Kopacz Synthesis and tumoricidal activity evaluation of new morin and quercetin sulfonic derivatives Acta Pol Pharm 59 2002 77 79
26. N. Orsolic, and I. Basic Water-soluble derivative of propolis and its polyphenolic compounds enhance tumoricidal activity of macrophages J Ethnopharmacol 102 2005 37 45
27. Kiyoshi Takeyama, Birgit Jung, Jae Jeong Shim, Pierre-Regis Burgel, Trang Dao-Pick, and Iris F. Ueki Activation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke Am J Physiol Lung Cell Mol Physiol 280 2001 L165 L172
28. Paula J. Busse, Teng Fei Zhang, Schofield J.D. Brian, Kilaru B.S. Saikiran, Sangita Patil, and Xiu-Min Li Decrease in airway mucous gene expression caused by treatment with anti-tumor necrosis factor α in a murine model of allergic asthma Ann Allergy Asthma Immunol 103 4 2009 295 303
29. T. Fujisawa, M.M. Chang, and R. Wu Regulation of airway MUC5AC expression by cytokines; the NF-κB paradigm Am J Respir Crit Care Med 179 2009 A4932
30. María J. Cuevas, Juliana Tieppo, Norma Possa Marroni, María J. Tuñón, and Javier González-Gallego Suppression of amphiregulin/epidermal growth factor receptor signals contributes to the protective effects of quercetin in cirrhotic rats J Nutr 141 7 2011 1299 1305
31. Alexandre Simões Dias, Marilene Porawski, María Alonso, Norma Marroni, Pilar S. Collado, and Javier González-Gallego Quercetin decreases oxidative stress, NF-κB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats J Nutr 135 2005 2299 2304