Revisited role for mucus hypersecretion in the pathogenesis of copd

European Respiratory Review

Volumn 19, Issue 116, 2010, Pages 109-112

  Cerveri, I ^a   Brusasco, V ^b  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Chronic obstructive pulmonary disease; Mucus hypersecretion

Indexed keywords

CHRONIC BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL FEATURE; CLINICAL RESEARCH; DRUG TARGETING; HISTOPATHOLOGY; HUMAN; INFLAMMATION; MUCUS HYPERSECRETION; MUCUS SECRETION; PATHOPHYSIOLOGY; PHENOTYPE; REVIEW; TREATMENT RESPONSE;

EXPECTORANTS; HUMANS; MUCUS; PNEUMONIA; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 77953177170     PISSN: 09059180     EISSN: None     Source Type: Journal    
DOI: 10.1183/09059180.00002710     Document Type: Review

References (26)

1. World Health Organization. 2008-2013 Action Plan for the Global Strategy for the Prevention and Control of Noncommunicable Diseases. 2008. Available from: www.who.int/nmh/publications/ncd_action_plan_en.pdf
2. Brusasco V, Crimi E, Pellegrino R. Airway inflammation in COPD: friend or foe? Am J Respir Crit Care Med 2007; 176: 425-426.
3. Beasley R, Weatherall M, Travers J, et al. Time to define the disorders of the syndrome of COPD. Lancet 2009; 374: 670-672.
4. Wedzicha JA, Seemungal TAR. COPD exacerbations: defining their cause and prevention. Lancet 2007; 370: 786-796.
5. Burgel PR, Nesme-Meyer P, Chanez P, et al. Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects. Chest 2009; 135: 975-982.
6. Global Strategy for the Diagnosis, Management and Prevention of COPD. Global Initiative for Chronic Obstructive Lung Disease. 2008. www.goldcopd.org Date last updated: January 2009. Date last accessed: July 2, 2009.
7. Friedlander AL, Lynch D, Dyar LA, et al. Phenotypes of chronic obstructive pulmonary disease. COPD 2007; 4: 355-384.
8. Weatherall M, Travers J, Shirtcliffe PM, et al. Distinct clinical phenotypes of airways disease defined by cluster analysis. Eur Respir J 2009; 34: 812-818.
9. Araya J, Cambier S, Markovics JA, et al. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest 2007; 117: 3551-3562.
10. MacNee W. Pathogenesis of chronic obstructive pulmonary disease. Clin Chest Med 2007; 28: 479-513.
11. Hogg JC, Timens W. The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol 2009; 4: 435-459.
12. Vesbo J, Hogg JC. Convergence of the epidemiology and pathology of COPD. Thorax 2006; 61: 86-88.
13. Brumfitt W, Willoghby MLN, Bromley LL. An evaluation of sputum examination in chronic bronchitis. Lancet 1957; 273: 1306-1309.
14. Thurlbeck WM, Angus GE. The relationship between chronic bronchitis and emphysema as assessed morphologically. Am Rev Respir Dis 1963; 87: 815-819.
15. Fletcher CM, Thinker CM. Chronic bronchitis. A further study of simple diagnostic methods in a working population. BMJ 1960; 1: 1941-1948.
16. Annesi I, Kauffman F. Is respiratory mucus hypersecretion really an innocent disorder? A 22-year mortality survey of 1,061 working men. Am Rev Respir Dis 1986; 134: 688-693.
17. Speizer FE, Fay ME, Dockery DW, et al. Chronic obstructive pulmonary disease mortality in six U.S. cities. Am Rev Respir Dis 1989; 140: Suppl. 3, S49-S55.
18. Vestbo J, Prescott E, Lange P. Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen City Heart Study Group. Am J Crit Care Med 1996; 153: 1530-1535.
19. Melton L. Does mucus hypersecretion matter in airway disease? Lancet 2002; 359: 1924.
20. Vestbo J, Epidemiological studies in mucus hypersecretion. In: Chadwick DJ, Goode JA, eds. Novartis Foundation Symposium 248: Mucus Hypersecration in Respiratory Disease. Malden, Wiley 2002; pp. 277-282.
21. Vestbo J, Lange P. Can GOLD Stage 0 provide information of prognostic value in COPD? Am J Respir Crit Care Med 2002; 166: 329-332.
22. Mannino DM. GOLD stage 0 COPD. It is real? Does it matter? Chest 2006; 130: 2309-2310.
23. De Marco R, Accordini S, Cerveri I, et al. Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm. Am J Respir Crit Care Med 2007; 175: 32-39.
24. Kohansal R, Martinez-Camblor P, Agusti A, et al. The natural history of chronic air flow obstruction revisited: an analysis of the Framingham offspring cohort. Am J Respir Crit Care Med 2009; 180: 3-10.
25. Hogg JC, Chu FS, Tan WC, et al. Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airways pathology. Am J Respir Crit Care Med 2007; 176: 454-459.
26. Randell SH. Airway epithelial stem cells and the pathophysiology of COPD. Proc Am Thorac Soc 2006; 3: 718-725.