Determining drug spatial distribution within controlled delivery tablets using MFX imaging

Journal of Controlled Release

Volumn 96, Issue 1, 2004, Pages 97-100

  Rigby, Sean P ^a   Van Der Walle, Christopher F ^b   Raistrick, James H ^c  

^a University of Bath   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c KEELE UNIVERSITY   (United Kingdom)

Author keywords

Drug spatial distribution; MFX imaging; Tablets

Indexed keywords

IMAGING SYSTEMS; POWDERS; QUALITY CONTROL; X RAYS;

DRUG DELIVERY SYSTEMS; DRUG SPATIAL DISTRIBUTION;

DRUG THERAPY;

AMIODARONE; HYDROXYPROPYLMETHYLCELLULOSE;

ANALYTIC METHOD; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG MIXTURE; FEASIBILITY STUDY; IMAGING SYSTEM; PARTICLE SIZE; PRIORITY JOURNAL; TABLET FORMULATION; TABLET MANUFACTURE; X RAY;

CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; RADIOGRAPHY; TABLETS; X-RAYS;

EID: 1842473845     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.01.007     Document Type: Article

References (6)

1. Lewis E.N., Carroll J.E., Clarke F. A near infrared view of pharmaceutical formulation analysis. NIR News. 12:2001;16.
2. Fyfe C.A., Blazek-Welsh A.I. Quantitative NMR imaging study of the mechanism of drug release from swelling hydroxypropylmethylcellulose tablets. J. Control. Release. 68:2000;313-333.
3. Koehler F.W., Lee E., Kidder L.H., Lewis E.N. Near infrared spectroscopy: the practical chemical imaging solution. Spectrosc. Eur. 14:2002;12.
4. Kiil S., Dam-Johansen K. Controlled drug delivery from swellable hydroxypropylmethylcellulose matrices: model-based analysis of observed radial front movements. J. Control. Release. 90:2003;1-21.
5. Wang Y., De Carlo F., Mancini D.C., McNulty I., Tieman B., Bresnahan J., Foster I., Insley J., Lane P., von Laszewski G., Kesselman C., Su M.-H., Thiebaux M. A high-throughput X-ray microtomography system at the Advanced Photon Source. Rev. Sci. Instrum. 72:2001;2062-2068.
6. Raistrick J.H. X-ray imaging in its element. Mater. World. 9:2001;11-13.