Diffusional release of a dispersed solute from planar and spherical matrices into finite external volume

Journal of Controlled Release

Volumn 43, Issue 2-3, 1997, Pages 175-182

  Abdekhodaie, M J ^a   Cheng, Y L ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Controlled release; Diffusional release kinetics; Exact solution; Finite external volume; Moving boundary problem

Indexed keywords

POLYMER;

ARTICLE; DIFFUSION; DRUG RELEASE; KINETICS; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL; SOLUBILITY; SOLUTION AND SOLUBILITY; SURFACE PROPERTY;

EID: 0031060456     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(96)01482-4     Document Type: Article

References (9)

1. G.A. Peyman and G.J. Ganiban, Delivery systems for intraocular routes. Adv. Drug Delivery Rev. 16 (1995) 107-123.
2. M. Otsuka, Y. Matsuda, Y. Suwa, J.L. Fox and W.I. Higuchi, A novel skeletal drug delivery system using a self-setting calcium phosphate cement. 5. Drug release behavior from a heterogeneous drug-loaded cement containing an anticancer drug. J. Pharm. Sci. 83(11) (1994) 1565-1568.
3. I.G. Needleman, Controlled drug release in periodontics: A review of new therapies. Br. Dent. J. 170 (1991) 405-407.
4. J. Crank, Mathematics of Diffusion, Clarendon Press, Oxford, 2nd ed., 1975, pp. 286-325.
5. T. Higuchi, Rate of release of medicaments from ointment bases containing drugs in suspension. J. Pharm. Sci. 50(10) (1961) 874-875.
6. T. Higuchi, Mechanism of sustained-action medication. J. Pharm. Sci. 52(12) (1963) 1145-1149.
7. P.I. Lee, Diffusional release of a solute from a polymeric matrix - approximate analytical solution. J. Membrane Sci. 7 (1980) 255-275.
8. D.R. Paul and S.K. McSpadden, Diffusional release of a solute from a polymer matrix. J. Membrane Sci. 1 (1976) 33-48.
9. M.J. Abdekhodaie and Y.-L. Cheng, Diffusional release of a dispersed solute from a spherical polymer matrix. J. Membrane Sci. in press (1996).