Statistical analysis of readthrough levels for nonsense mutations in mammalian cells reveals a major determinant of response to gentamicin

PLoS Genetics

Volumn 8, Issue 3, 2012, Pages

  Floquet, Célia ^a,b   Hatin, Isabelle ^a,b   Rousset, Jean Pierre ^a,b   Bidou, Laure ^a,b,c  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b CNRS   (France)

^c SORBONNE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; GENTAMICIN; NUCLEOTIDE; TRANSFER RNA; URACIL; AMINO ACID; PROTEIN SYNTHESIS INHIBITOR;

ANIMAL CELL; ANTIBIOTIC THERAPY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG RESPONSE; EMBRYO; GENE SEQUENCE; GENETIC TRANSCRIPTION; MAMMAL CELL; MOUSE; NONHUMAN; NONSENSE MUTATION; READTHROUGH LEVEL; STATISTICAL ANALYSIS; STOP CODON; DRUG EFFECT; GENETICS; HUMAN; RNA TRANSLATION;

MAMMALIA;

AMINO ACIDS; CELLS, CULTURED; CODON, NONSENSE; CODON, TERMINATOR; CYTOSINE; GENTAMICINS; HUMANS; PEPTIDE CHAIN TERMINATION, TRANSLATIONAL; PROTEIN SYNTHESIS INHIBITORS; RNA, TRANSFER; URACIL;

EID: 84859239887     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002608     Document Type: Article

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