Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Singh, Brijesh Kumar ^a,b   Tripathi, Madhulika ^a   Chaudhari, Bhushan P ^a   Pandey, Pramod K ^b   Kakkar, Poonam ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b BUNDELKHAND UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE; ALANINE AMINOTRANSFERASE; APOPTOSIS INDUCING FACTOR; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BIOLOGICAL MARKER; CAMPHENE; CASPASE 3; CASPASE 9; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C; DNA; ENDONUCLEASE G; GERANIOL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; MITOCHONDRIAL NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NIMESULIDE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SILYMARIN; TERPENE DERIVATIVE; UNCLASSIFIED DRUG; ANTIOXIDANT; APOPTOSIS REGULATORY PROTEIN; BIOLOGICAL PRODUCT; NUCLEOTIDE; OXIDIZING AGENT; SULFONAMIDE; TERPENE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BODY WEIGHT; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DRUG MEGADOSE; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HISTOPATHOLOGY; IMMUNOBLOTTING; IN VIVO STUDY; LIVER TOXICITY; MACROMOLECULE; MALE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRION SWELLING; MOLECULAR MECHANICS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; RAT; SPRAGUE DAWLEY RAT; STRUCTURE ANALYSIS; ANIMAL; CELL DEATH; CELL PROTECTION; CYTOLOGY; DRUG EFFECT; ELECTRON TRANSPORT; GENETIC TRANSCRIPTION; HOMEOSTASIS; LIPID METABOLISM; LIVER; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PATHOLOGY; PERMEABILITY; PROTEIN DEGRADATION; SECRETION;

RATTUS;

ANIMALS; ANTIOXIDANTS; APOPTOSIS REGULATORY PROTEINS; BIOLOGICAL AGENTS; CASPASE 3; CASPASE 9; CELL DEATH; CYTOPROTECTION; DNA DAMAGE; ELECTRON TRANSPORT; HOMEOSTASIS; LIPID METABOLISM; LIVER; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NUCLEOTIDES; OXIDANTS; OXIDATIVE STRESS; PERMEABILITY; PROTEOLYSIS; RATS; RATS, SPRAGUE-DAWLEY; SULFONAMIDES; TERPENES; TRANSCRIPTION, GENETIC;

EID: 84859226961     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034200     Document Type: Article

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