Nimesulide aggravates redox imbalance and calcium dependent mitochondrial permeability transition leading to dysfunction in vitro

Toxicology

Volumn 275, Issue 1-3, 2010, Pages 1-9

  Singh, Brijesh Kumar ^a,b   Tripathi, Madhulika ^a   Pandey, Pramod Kumar ^b   Kakkar, Poonam ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b BUNDELKHAND UNIVERSITY   (India)

Author keywords

Ca2+ overload; Membrane permeability transition; Mitochondria; Nimesulide; Reactive oxygen species; Redox regulation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CALCIUM ION; DICHLORODIHYDROFLUORESCEIN; GLUTATHIONE; NIMESULIDE; PYRIDINE NUCLEOTIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RHODAMINE 123;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOFLUORESCENCE; CELL DEATH; CELL STRESS; CONTROLLED STUDY; DEPOLARIZATION; ELECTRON TRANSPORT; FLUORESCENCE; IN VITRO STUDY; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL PERMEABILITY; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CALCIUM; MALE; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; OXIDATION-REDUCTION; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SULFONAMIDES;

RATTUS;

EID: 77954815921     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.05.001     Document Type: Article

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