Erythropoietin receptor signaling is membrane raft dependent

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  McGraw, Kathy L ^a,b   Fuhler, Gwenny M ^c   Johnson, Joseph O ^a   Clark, Justine A ^a   Caceres, Gisela C ^a   Sokol, Lubomir ^a   List, Alan F ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE LYN; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; STAT5 PROTEIN; ENZYME INHIBITOR; PHOSPHOPROTEIN;

ARTICLE; CELL AGGREGATION; CELL MEMBRANE; CELL STIMULATION; CELLULAR PARAMETERS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ERYTHROID PRECURSOR CELL; HUMAN; HUMAN CELL; LIPID RAFT; MEMBRANE BIOLOGY; MEMBRANE RAFT; MEMBRANE RAFT ASSEMBLY; MEMBRANE RAFT COALESCENCE; PRIMARY ERYTHROID BURST; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; ANIMAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; ENZYME INHIBITORS; ERYTHROID PRECURSOR CELLS; HUMANS; MEMBRANE MICRODOMAINS; PHOSPHOPROTEINS; PROTEIN TRANSPORT; RAC1 GTP-BINDING PROTEIN; RECEPTORS, ERYTHROPOIETIN; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR;

EID: 84859221013     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034477     Document Type: Article

References (33)

1. Witthuhn B, Quelle F, Silvennoinen O, Yi T, Tang B, et al. (1993) Jak2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 74: 227-236.
2. Wojchowski D, Gregory R, Miller C, Pandit A, Pircher T, (1999) Signal transduction in the erythropoietin receptor system. Experimental cell research 253: 143-156.
3. Rane SG, Reddy EP, (2002) JAKs, STATs and Src kinases in hematopoiesis. Oncogene 21: 3334-3358.
4. Karur VG, Lowell CA, Besmer P, Agosti V, Wojchowski DM, (2006) Lyn kinase promotes erythroblast expansion and late-stage development. Blood 108: 1524-1532.
5. Tilbrook PA, Ingley E, Williams JH, Hibbs ML, Klinken SP, (1997) Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells. The EMBO journal 16: 1610-1619.
6. Harder KW, Quilici C, Naik E, Inglese M, Kountouri N, et al. (2004) Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1. Blood 104: 3901-3910.
7. Ingley E, McCarthy DJ, Pore JR, Sarna MK, Adenan AS, et al. (2005) Lyn deficiency reduces GATA-1, EKLF and STAT5, and induces extramedullary stress erythropoiesis. Oncogene 24: 336-343.
8. Chin H, Arai A, Wakao H, Kamiyama R, Miyasaka N, et al. (1998) Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway. Blood 91: 3734-3745.
9. Galbiati F, Razani B, Lisanti M, (2001) Emerging themes in lipid rafts and caveolae. Cell 160: 403-411.
10. Murphy SC, Fernandez-Pol S, Chung PH, Prasanna Murthy SN, Milne SB, et al. (2007) Cytoplasmic remodeling of erythrocyte raft lipids during infection by the human malaria parasite Plasmodium falciparum. Blood 110: 2132-2139.
11. Harder T, Scheiffele P, Verkade P, Simons K, (1998) Lipid domain structure of the plasma membrane revealed by patching of membrane components. The journal of cell biology 141: 929-942.
12. Simons K, Toomre D, (2000) Lipid rafts and signal transduction. Nature review molecular cell biology 1: 31-39.
13. Hunter T, (2000) Signaling-2000 and beyond. Cell 100: 113-127.
14. Janes PW, Ley SC, Magee AI, Kabouridis PS, (2000) The role of lipid rafts in T cell antigen receptor (TCR) signalling. Seminars in immunology 12: 23-34.
15. Langlet C, Bernard AM, Drevot P, He HT, (2000) Membrane rafts and signaling by the multichain immune recognition receptors. Current opinion in immunology 12: 250-255.
16. Kabouridis PS, Jury EC, (2008) Lipid rafts and T-lymphocyte function: implications for autoimmunity. FEBS Letters 582: 3711-3718.
17. Jury EC, Isenberg DA, Mauri C, Ehrenstein MR, (2006) Atorvastatin restores Lck expression and lipid raft-associated signaling in T cells from patients with systemic lupus erythematosus. Journal of immunology 177: 7416-7422.
18. Kabouridis PS, Janzen J, Magee AL, Ley SC, (2000) Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes. European journal of immunology 30: 954-963.
19. Xavier R, Brennan T, Li Q, McCormack C, Seed B, (1998) Membrane compartmentation is required for efficient T cell activation. Immunity 8: 723-732.
20. Hillyard DZ, Cameron AJ, McDonald KJ, Thomson J, MacIntyre A, et al. (2004) Simvastatin inhibits lymphocyte function in normal subjects and patients with cardiovascular disease. Atherosclerosis 175: 305-313.
21. Rentero C, Zech T, Quinn CM, Engelhardt K, Williamson D, et al. (2008) Functional implications of plasma membrane condensation for T cell activation. PloS one 3: e2262.
22. Elliott S, Busse L, Bass MB, Lu H, Sarosi I, et al. (2006) Anti-Epo receptor antibodies do not predict Epo receptor expression. Blood 107: 1892-1895.
23. Sinclair A, Coxon A, McCaffery I, Kaufman S, Paweletz K, et al. (2010) Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells. Blood 115: 4264-4272.
24. Swift S, Ellison A, Kassner P, McCaffery I, Rossi J, et al. (2010) Absence of functional EpoR expresion in human tumor cell lines. Blood 115: 4254-4263.
25. Elliott S, Busse L, McCaffery I, Rossi J, Sinclair A, et al. (2010) Identification of a sensitive anti-erythropoietin receptor monoclonal antibody allows detection of low levels of EpoR in cells. Journal of immunological methods 352: 126-139.
26. Liang K, Esteva FJ, Albarracin C, Stemke-Hale K, Lu Y, et al. (2010) Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation. Cancer cell 18: 423-435.
27. Heasman SJ, Ridley AJ, (2008) Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nature reviews Molecular cell biology 9: 690-701.
28. Ji P, Lodish HF, (2010) Rac GTPases play multiple roles in erythropoiesis. Haematologica 95: 2-4.
29. Kalfa TA, Pushkaran S, Zhang X, Johnson JF, Pan D, et al. (2010) Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen. Haematologica 95: 27-35.
30. Fuhler GM, Cadwallader KA, Knol GJ, Chilvers ER, Drayer AL, et al. (2004) Disturbed granulocyte macrophage-colony stimulating factor priming of phosphatidylinositol 3,4,5-trisphosphate accumulation and Rac activation in fMLP-stimulated neutrophils from patients with myelodysplasia. Journal of leukocyte biology 76: 254-262.
31. Fuhler GM, Blom NR, Coffer PJ, Drayer AL, Vellenga E, (2007) The reduced GM-CSF priming of ROS production in granulocytes from patients with myelodysplasia is associated with an impaired lipid raft formation. Journal of leukocyte biology 81: 449-457.
32. Hoefsloot LH, van Amelsvoort MP, Broeders LC, van der Plas DC, van Lom K, et al. (1997) Erythropoietin-induced activation of STAT5 is impaired in the myelodysplastic syndrome. Blood 89: 1690-1700.
33. Bellamy WT, Richter L, Sirjani D, Roxas C, Glinsmann-Gibson B, et al. (2001) Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes. Blood 97: 1427-1434.