Fluorescein Analogues Inhibit SecA ATPase: The First Sub-micromolar Inhibitor of Bacterial Protein Translocation

ChemMedChem

Volumn 7, Issue 4, 2012, Pages 571-577

  Huang, Ying Ju ^a   Wang, Hongyun ^a,c   Gao, Fen Biao ^b   Li, Minyong ^a,d   Yang, Hsiuchin ^a   Wang, Binghe ^a   Tai, Phang C ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c INSTITUTE OF BIOPHYSICS   (China)

^d SHANDONG UNIVERSITY   (China)

Author keywords

Antimicrobial agents; ATPase inhibitors; Membrane proteins; Protein translocation; SecA

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BACTERIAL PROTEIN; ERYTHROSINE; FLUORESCEIN DERIVATIVE; PROTEIN SECA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; ROSE BENGAL;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERICIDAL ACTIVITY; CATALYSIS; CONTROLLED STUDY; CORRELATIONAL STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; IC 50; IN VITRO STUDY; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN TARGETING; PROTEIN TRANSPORT; UPREGULATION;

ADENOSINE TRIPHOSPHATASES; ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ERYTHROSINE; ESCHERICHIA COLI; FLUORESCEIN; INHIBITORY CONCENTRATION 50; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; PROTEIN TRANSPORT; ROSE BENGAL;

EID: 84859176724     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100594     Document Type: Article

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