메뉴 건너뛰기




Volumn 5, Issue 2, 2010, Pages 78-98

Encoding the frequency dependence in MRI contrast media: The emerging class of CEST agents

Author keywords

CEST agents; Lanthanides; Molecular imaging; MRI; Proton exchange; Smart agents

Indexed keywords

CONTRAST MEDIUM; LIPOCEST AGENT; PARACEST AGENT; POLYARGININE; SUPRACEST AGENT; UNCLASSIFIED DRUG;

EID: 77951553892     PISSN: 15554309     EISSN: 15554317     Source Type: Journal    
DOI: 10.1002/cmmi.369     Document Type: Review
Times cited : (124)

References (87)
  • 3
    • 15444374661 scopus 로고    scopus 로고
    • 19F: A versatile reporter for non-invasive physiology and pharmacology using magnetic resonance
    • DOI 10.2174/0929867053507342
    • Yu JX, Kodibagkar VD, Cui W, Mason RP. 19F: a versatile reporter for non-invasive physiology and pharmacology using magnetic resonance. Curr Med Chem 2005; 12: 819-848. (Pubitemid 40394333)
    • (2005) Current Medicinal Chemistry , vol.12 , Issue.7 , pp. 819-848
    • Yu, J.-X.1    Kodibagkar, V.D.2    Cui, W.3    Mason, R.P.4
  • 4
    • 0024573913 scopus 로고
    • Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo
    • Wolff SD, Balaban RS. Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med 1989; 10: 135-144.
    • (1989) Magn Reson Med , vol.10 , pp. 135-144
    • Wolff, S.D.1    Balaban, R.S.2
  • 6
    • 0034145982 scopus 로고    scopus 로고
    • A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST)
    • Ward KM, Aletras AH, Balaban RS. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). J Magn Reson 2000; 143: 79-87.
    • (2000) J Magn Reson , vol.143 , pp. 79-87
    • Ward, K.M.1    Aletras, A.H.2    Balaban, R.S.3
  • 7
    • 33846851242 scopus 로고
    • Study of moderately rapid chemical exchange reactions by means of nuclear magnetic double resonance
    • Forsen S, Hoffman RA. Study of moderately rapid chemical exchange reactions by means of nuclear magnetic double resonance, J Chem Phys 1963; 39: 2892-2901.
    • (1963) J Chem Phys , vol.39 , pp. 2892-2901
    • Forsen, S.1    Hoffman, R.A.2
  • 8
    • 21244455698 scopus 로고    scopus 로고
    • Optimization of the irradiation power in chemical exchange dependent saturation transfer experiments
    • DOI 10.1016/j.jmr.2005.04.005, PII S109078070500128X
    • Sun PZ, van Zijl PCM, Zhou J. Optimization of the irradiation power in chemical exchange dependent saturation transfer experiments. J Magn Reson 2005; 175: 193-200. (Pubitemid 40891674)
    • (2005) Journal of Magnetic Resonance , vol.175 , Issue.2 , pp. 193-200
    • Sun, P.Z.1    Van Zijl, P.C.M.2    Zhou, J.3
  • 9
    • 16444362041 scopus 로고    scopus 로고
    • Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI
    • DOI 10.1002/mrm.20408
    • Woessner DE, Zhang S, Merritt ME, Sherry AD. Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI. Magn Reson Med 2005; 53: 790-799. (Pubitemid 40478426)
    • (2005) Magnetic Resonance in Medicine , vol.53 , Issue.4 , pp. 790-799
    • Woessner, D.E.1    Zhang, S.2    Merritt, M.E.3    Sherry, A.D.4
  • 10
    • 55749088003 scopus 로고    scopus 로고
    • Four-pool modeling of proton exchange processes in biological systems in the presence of MRI-paramagnetic chemical exchange saturation transfer (PARACEST) agents
    • Li AX, Hudson RHE, Barrett JW, Jones CK, Pasternak SH, Bartha R. Four-pool modeling of proton exchange processes in biological systems in the presence of MRI-paramagnetic chemical exchange saturation transfer (PARACEST) agents. Magn Reson Med 2008; 60: 1197-1206.
    • (2008) Magn Reson Med , vol.60 , pp. 1197-1206
    • Li, A.X.1    Hudson, R.H.E.2    Barrett, J.W.3    Jones, C.K.4    Pasternak, S.H.5    Bartha, R.6
  • 11
    • 33747238228 scopus 로고    scopus 로고
    • Chemical exchange saturation transfer imaging and spectroscopy
    • DOI 10.1016/j.pnmrs.2006.01.001, PII S0079656506000033
    • Zhou J, van Zijl PCM. Chemical exchange saturation transfer imaging and spectroscopy. Prog NMR Spectr 2006; 48: 109-136. (Pubitemid 44236131)
    • (2006) Progress in Nuclear Magnetic Resonance Spectroscopy , vol.48 , Issue.2-3 , pp. 109-136
    • Zhou, J.1    Zijl, P.C.M.V.2
  • 12
    • 49049101091 scopus 로고    scopus 로고
    • Imaging pH using the chemical exchange saturation transfer (CEST) MRI: Correction of concomitant RF irradiation effects to quantify CEST MRI for chemical exchange rate and pH
    • Sun PZ, Sorensen AG. Imaging pH using the chemical exchange saturation transfer (CEST) MRI: correction of concomitant RF irradiation effects to quantify CEST MRI for chemical exchange rate and pH. Magn Reson Med 2008; 60: 390-397.
    • (2008) Magn Reson Med , vol.60 , pp. 390-397
    • Sun, P.Z.1    Sorensen, A.G.2
  • 13
    • 36849059642 scopus 로고    scopus 로고
    • 1 field inhomogeneities in pH-sensitive chemical exchange saturation transfer (CEST) imaging
    • 1 field inhomogeneities in pH-sensitive chemical exchange saturation transfer (CEST) imaging. Magn Reson Med 2007; 58: 1207-1215.
    • (2007) Magn Reson Med , vol.58 , pp. 1207-1215
    • Sun, P.Z.1    Farrar, C.T.2    Sorensen, A.G.3
  • 14
    • 57649220769 scopus 로고    scopus 로고
    • Development and validation of a smoothing-splines-based correction method for improving the analysis of CEST-MR images
    • Stancanello J, Terreno E, Delli Castelli D, Cabella C, Uggeri F, Aime S. Development and validation of a smoothing-splines-based correction method for improving the analysis of CEST-MR images. Contrast Media Mol Imag 2008; 3: 136-149.
    • (2008) Contrast Media Mol Imag , vol.3 , pp. 136-149
    • Stancanello, J.1    Terreno, E.2    Delli Castelli, D.3    Cabella, C.4    Uggeri, F.5    Aime, S.6
  • 15
    • 67049160813 scopus 로고    scopus 로고
    • Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments
    • Kim M, Gillen J, Landman BA, Zhou J, van Zijl PC.Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments. Magn Reson Med 2009; 61: 1441-1450.
    • (2009) Magn Reson Med , vol.61 , pp. 1441-1450
    • Kim, M.1    Gillen, J.2    Landman, B.A.3    Zhou, J.4    Van Zijl, P.C.5
  • 16
    • 42549100419 scopus 로고    scopus 로고
    • Relaxation-compensated fast multislice amide proton transfer (APT) imaging of acute ischemic stroke
    • DOI 10.1002/mrm.21591
    • Sun PZ, Murata Y, Lu J, Wang X, Lo EH, Sorensen AG. Relaxation- compensated fast multislice amide proton transfer (APT) imaging of acute ischemic stroke. Magn Reson Med 2008; 59: 1175-1182. (Pubitemid 351590532)
    • (2008) Magnetic Resonance in Medicine , vol.59 , Issue.5 , pp. 1175-1182
    • Sun, P.Z.1    Murata, Y.2    Lu, J.3    Wang, X.4    Lo, E.H.5    Sorensen, A.G.6
  • 19
    • 49349108757 scopus 로고    scopus 로고
    • Chemical exchange saturation transfer by intermolecular double-quantum coherence
    • Ling W, Eliav U, Navon G, Jerschow A. Chemical exchange saturation transfer by intermolecular double-quantum coherence. J Magn Reson 2008; 194: 29-32.
    • (2008) J Magn Reson , vol.194 , pp. 29-32
    • Ling, W.1    Eliav, U.2    Navon, G.3    Jerschow, A.4
  • 20
    • 47649111304 scopus 로고    scopus 로고
    • Improvement in the contrast of CEST MRI via intermolecular double quantum coherences
    • DOI 10.1088/0031-9155/53/14/N03, PII S0031915508659205
    • Zhang S, Zhu X, Chen Z, Cai C, Lin T, Zhong J. Improvement in the contrast of CEST MRI via intermolecular double quantum coherences. Phys Med Biol 2008; 53: N287-N296. (Pubitemid 352020281)
    • (2008) Physics in Medicine and Biology , vol.53 , Issue.14
    • Zhang, S.1    Zhu, X.2    Chen, Z.3    Cai, C.4    Lin, T.5    Zhong, J.6
  • 21
    • 33744523144 scopus 로고    scopus 로고
    • Paramagnetic lanthanide complexes as PARACEST agents for medical imaging
    • DOI 10.1039/b509907m
    • Woods M, Woessner DE, Sherry AD. Paramagnetic lanthanide complexes as PARACEST agents for medical imaging. Chem Soc Rev 2006; 35: 500-511. (Pubitemid 43815284)
    • (2006) Chemical Society Reviews , vol.35 , Issue.6 , pp. 500-511
    • Woods, M.1    Woessner, D.E.2    Sherry, A.D.3
  • 23
    • 0000421009 scopus 로고
    • NMR imaging of labile proton-exchange
    • Wolff SD, Balaban RS. NMR imaging of labile proton-exchange. J Magn Reson Imag 1990; 86: 164-169.
    • (1990) J Magn Reson Imag , vol.86 , pp. 164-169
    • Wolff, S.D.1    Balaban, R.S.2
  • 25
    • 0035812395 scopus 로고    scopus 로고
    • Sensitive NMR detection of cationic-polymer-based gene delivery systems using saturation transfer via proton exchange [18]
    • DOI 10.1021/ja0158455
    • Goffeney N, Bulte JW, Duyn J, Bryant LH Jr, van Zijl PC. Sensitive NMR detection of cationic-polymer-based gene delivery systems using saturation transfer via proton exchange. J Am Chem Soc 2001; 123: 8628-8629. (Pubitemid 32808097)
    • (2001) Journal of the American Chemical Society , vol.123 , Issue.35 , pp. 8628-8629
    • Goffeney, N.1    Bulte, J.W.M.2    Duyn, J.3    Bryant Jr., L.H.4    Van Zijl, P.C.M.5
  • 26
    • 0038101642 scopus 로고    scopus 로고
    • Sensitive CEST agents based on nucleic acid imino proton exchange: Detection of poly(rU) and of a dendrimer-poly(rU) model for nucleic acid delivery and pharmacology
    • DOI 10.1002/mrm.10463
    • Snoussi K, Bulte JW, Gueron M, van Zijl PC. Sensitive CEST agents based on nucleic acid imino proton exchange: detection of poly(rU) and of a dendrimer-poly(rU) model for nucleic acid delivery and pharmacology. Magn Reson Med 2003; 49: 998-1005. (Pubitemid 36627277)
    • (2003) Magnetic Resonance in Medicine , vol.49 , Issue.6 , pp. 998-1005
    • Snoussi, K.1    Bulte, J.W.M.2    Gueron, M.3    Van Zijl, P.C.M.4
  • 27
    • 0032112415 scopus 로고    scopus 로고
    • Detection of Proton Chemical Exchange between Metabolites and Water in Biological Tissues
    • Guivel-Scharen V, Sinnwell T, Wolff SD, Balaban RS. Detection of proton chemical exchange between metabolites and water in biological tissues. J Magn Reson 1998; 133: 36-45. (Pubitemid 128450608)
    • (1998) Journal of Magnetic Resonance , vol.133 , Issue.1 , pp. 36-45
    • Guivel-Scharen, V.1    Sinnwell, T.2    Wolff, S.D.3    Balaban, R.S.4
  • 29
    • 0042466426 scopus 로고    scopus 로고
    • Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI
    • DOI 10.1038/nm907
    • Zhou J, Payen JF, Wilson DA, Traystman RJ, van Zijl PC. Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Natl Med 2003; 9: 1085-1090. (Pubitemid 37021791)
    • (2003) Nature Medicine , vol.9 , Issue.8 , pp. 1085-1090
    • Zhou, J.1    Payen, J.-F.2    Wilson, D.A.3    Traystman, R.J.4    Van Zijl, P.C.M.5
  • 35
    • 0037621925 scopus 로고    scopus 로고
    • Physical characteristics of lanthanide complexes that act as magnetization transfer (MT) contrast agents
    • Zhang SR, Sherry AD. Physical characteristics of lanthanide complexes that act as magnetization transfer (MT) contrast agents. J Solid State Chem 2003; 171: 38-43.
    • (2003) J Solid State Chem , vol.171 , pp. 38-43
    • Zhang, S.R.1    Sherry, A.D.2
  • 36
    • 0036204319 scopus 로고    scopus 로고
    • Paramagnetic lanthanide(III) complexes as pH-sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI applications
    • DOI 10.1002/mrm.10106
    • Aime S, Barge A, Delli Castelli D, Fedeli F, Mortillaro A, Nielsen FU, Terreno E. Paramagnetic lanthanide(III) complexes as pH-sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI applications. Magn Reson Med 2002; 47: 639-648. (Pubitemid 34263776)
    • (2002) Magnetic Resonance in Medicine , vol.47 , Issue.4 , pp. 639-648
    • Aime, S.1    Barge, A.2    Castelli, D.D.3    Fedeli, F.4    Mortillaro, A.5    Nielsen, F.U.6    Terreno, E.7
  • 37
    • 1642351484 scopus 로고    scopus 로고
    • Ln(III)-DOTAMGly Complexes: A Versatile Series to Assess the Determinants of the Efficacy of Paramagnetic Chemical Exchange Saturation Transfer Agents for Magnetic Resonance Imaging Applications
    • DOI 10.1097/01.rli.0000116607.26372.d0
    • Terreno E, Delli Castelli D, Cravotto G, Milone L, Aime S. Ln(III)-DOTAMGly complexes: a versatile series to assess the determinants of the efficacy of paramagnetic chemical exchange saturation transfer agents for magnetic resonance imaging applications. Invest Radiol 2004; 39: 235-243. (Pubitemid 38391789)
    • (2004) Investigative Radiology , vol.39 , Issue.4 , pp. 235-243
    • Terreno, E.1    Castelli, D.D.2    Cravotto, G.3    Milone, L.4    Aime, S.5
  • 39
    • 34648828685 scopus 로고    scopus 로고
    • A robust and convergent synthesis of dipeptide-DOTAM conjugates as chelators for lanthanide ions: New PARACEST MRI agents
    • DOI 10.1021/bc0701287
    • Wojciechowski F, Suchy M, Li AX, Azab HA, Bartha R, Hudson RHE. A robust and convergent synthesis of dipeptide-DOTAM conjugates as chelators for lanthanide ions: new PARACEST MRI agents. Bioconjug Chem 2007; 18: 1625-1636. (Pubitemid 47464073)
    • (2007) Bioconjugate Chemistry , vol.18 , Issue.5 , pp. 1625-1636
    • Wojciechowski, F.1    Suchy, M.2    Li, A.X.3    Azab, H.A.4    Bartha, R.5    Hudson, R.H.E.6
  • 40
    • 44449097095 scopus 로고    scopus 로고
    • 3+ DOTAM-Gly-Lys-OH: Synthesis and magnetic properties of potential PARACEST MRI contrast agents
    • 3+ DOTAM-Gly-Lys-OH: synthesis and magnetic properties of potential PARACEST MRI contrast agents. Bioorg Med Chem 2008; 16: 6156-6166.
    • (2008) Bioorg Med Chem , vol.16 , pp. 6156-6166
    • Suchy, M.1    Li, A.X.2    Bartha, R.3    Hudson, R.H.E.4
  • 42
    • 68149176865 scopus 로고    scopus 로고
    • Cerium(III), europium(III), and ytterbium(III) complexes with alcohol donor groups as chemical exchange saturation transfer agents for MRI
    • Huang C-H, Morrow JR. Cerium(III), europium(III), and ytterbium(III) complexes with alcohol donor groups as chemical exchange saturation transfer agents for MRI. Inorg Chem 2009; 48: 7237-7243.
    • (2009) Inorg Chem , vol.48 , pp. 7237-7243
    • Huang, C.-H.1    Morrow, J.R.2
  • 43
    • 58149280565 scopus 로고    scopus 로고
    • The thulium complex of 1,4,7,10-tetrakis{[N-(1H-imidazol-2-yl)-carbamoyl] methyl}-1,4,7,10-tetraazacyclododecane (dotami) as a ParaCEST contrast agent
    • Burdinski D, Lub J, Pikkemaat JA, Langereis S, Gruell H, ten Hoeve W. The thulium complex of 1,4,7,10-tetrakis{[N-(1H-imidazol-2-yl)-carbamoyl]methyl}-1, 4,7,10-tetraazacyclododecane (dotami) as a ParaCEST contrast agent. Chem Biodiv 2008; 5: 1505-1512.
    • (2008) Chem Biodiv , vol.5 , pp. 1505-1512
    • Burdinski, D.1    Lub, J.2    Pikkemaat, J.A.3    Langereis, S.4    Gruell, H.5    Ten Hoeve, W.6
  • 46
    • 70350049069 scopus 로고    scopus 로고
    • Tracking the relative in vivo pharmacokinetics of nanoparticles with PARACEST MRI
    • Meser Ali M, Yoo B, Pagel MD. Tracking the relative in vivo pharmacokinetics of nanoparticles with PARACEST MRI. Mol Pharm 2009; 6: 1409-1416.
    • (2009) Mol Pharm , vol.6 , pp. 1409-1416
    • Meser Ali, M.1    Yoo, B.2    Pagel, M.D.3
  • 48
    • 0141670309 scopus 로고    scopus 로고
    • Supramolecular adducts between poly-L-arginine and [TmIIIdotp]: A route to sensitivity-enhanced magnetic resonance imaging-chemical exchange saturation transfer agents
    • Aime S, Delli Castelli D, Terreno E. Supramolecular adducts between poly-L-arginine and [TmIIIdotp]: a route to sensitivity-enhanced magnetic resonance imaging-chemical exchange saturation transfer agents. Angew Chem Int Ed Engl 2003; 42: 4527-4529.
    • (2003) Angew Chem Int Ed Engl , vol.42 , pp. 4527-4529
    • Aime, S.1    Delli Castelli, D.2    Terreno, E.3
  • 49
    • 24644481042 scopus 로고    scopus 로고
    • Highly sensitive MRI chemical exchange saturation transfer agents using liposomes
    • Aime S, Delli Castelli D, Terreno E. Highly sensitive MRI chemical exchange saturation transfer agents using liposomes. Angew Chem Int Ed Engl 2005; 44: 5513-5515.
    • (2005) Angew Chem Int Ed Engl , vol.44 , pp. 5513-5515
    • Aime, S.1    Delli Castelli, D.2    Terreno, E.3
  • 50
    • 0038240685 scopus 로고    scopus 로고
    • Lanthanides as shift and relaxation agents in elucidating the structure of proteins and nucleic acids
    • Sigel A, Sigel H (eds). Marcel Dekker: New York
    • Geraldes CFGC, Luchinat C. Lanthanides as shift and relaxation agents in elucidating the structure of proteins and nucleic acids. In Metal ions in biological systems, Sigel A, Sigel H (eds). Vol. 40 Marcel Dekker: New York, 2003; 513-588.
    • (2003) Metal Ions in Biological Systems , vol.40 , pp. 513-588
    • Geraldes, C.F.G.C.1    Luchinat, C.2
  • 52
    • 60749121437 scopus 로고    scopus 로고
    • Osmotically shrunken LIPOCEST agents: An innovative class of magnetic resonance imaging contrast media based on chemical exchange saturation transfer
    • Terreno E, Delli Castelli D, Violante E, Sanders HM, Sommerdijk NA, Aime S. Osmotically shrunken LIPOCEST agents: an innovative class of magnetic resonance imaging contrast media based on chemical exchange saturation transfer. Chem Eur J 2009; 15: 1440-1448.
    • (2009) Chem Eur J , vol.15 , pp. 1440-1448
    • Terreno, E.1    Delli Castelli, D.2    Violante, E.3    Sanders, H.M.4    Sommerdijk, N.A.5    Aime, S.6
  • 56
    • 0025361232 scopus 로고
    • Bulk magnetic susceptibility shifts in NMR studies of compartmentalized samples. Use of paramagnetic reagents
    • Chu SCK, Xu Y, Balschi JA, Springer CS Jr. Bulk magnetic susceptibility shifts in NMR studies of compartmentalized samples. Use of paramagnetic reagents. Magn Reson Med 1990; 13: 239-262.
    • (1990) Magn Reson Med , vol.13 , pp. 239-262
    • Chu, S.C.K.1    Xu, Y.2    Balschi, J.A.3    Springer Jr., C.S.4
  • 58
    • 0034753139 scopus 로고    scopus 로고
    • Osmotically induced shape changes of large unilamellar vesicles measured by dynamic light scattering
    • Pencer J, White GF, Hallett FR. Osmotically induced shape changes of large unilamellar vesicles measured by dynamic light scattering. Biophys J 2001; 81: 2716-2728. (Pubitemid 33020058)
    • (2001) Biophysical Journal , vol.81 , Issue.5 , pp. 2716-2728
    • Pencer, J.1    White, G.F.2    Hallett, F.R.3
  • 59
    • 0000471160 scopus 로고    scopus 로고
    • Magnetically aligned membrane model systems with positive order parameter: Switching the sign of S-zz with paramagnetic ions
    • Prosser RS, Hunt SA, DiNatale JA, Vold RR. Magnetically aligned membrane model systems with positive order parameter: switching the sign of S-zz with paramagnetic ions. J Am Chem Soc 1996; 118: 269-270.
    • (1996) J Am Chem Soc , vol.118 , pp. 269-270
    • Prosser, R.S.1    Hunt, S.A.2    DiNatale, J.A.3    Vold, R.R.4
  • 60
    • 0033257895 scopus 로고    scopus 로고
    • Lanthanide Chelates as Bilayer Alignment Tools in NMR Studies of Membrane-Associated Peptides
    • Prosser RS, Bryant H, Bryant RG, Vold RR. Lanthanide chelates as bilayer alignment tools in NMR studies of membrane-associated peptides. J Magn Reson 1999; 141: 256-260. (Pubitemid 129608324)
    • (1999) Journal of Magnetic Resonance , vol.141 , Issue.2 , pp. 256-260
    • Prosser, R.S.1    Bryant, H.2    Bryant, R.G.3    Vold, R.R.4
  • 62
    • 71549150294 scopus 로고    scopus 로고
    • Lanthanide-loaded paramagnetic liposomes as switchable magnetically oriented nanovesicles
    • Aime S, Delli Castelli D, Terreno E. Lanthanide-loaded paramagnetic liposomes as switchable magnetically oriented nanovesicles. Meth Enzymol 2009; 464: 193-210.
    • (2009) Meth Enzymol , vol.464 , pp. 193-210
    • Aime, S.1    Delli Castelli, D.2    Terreno, E.3
  • 67
    • 0033766573 scopus 로고    scopus 로고
    • Determination of pH using water protons and chemical exchange dependent saturation transfer (CEST)
    • Ward KM, Balaban RS. Determination of pH using water protons and chemical exchange dependent saturation transfer (CEST). Magn Reson Med 2000; 44: 799-802.
    • (2000) Magn Reson Med , vol.44 , pp. 799-802
    • Ward, K.M.1    Balaban, R.S.2
  • 69
    • 0037014039 scopus 로고    scopus 로고
    • The amide protons of an ytterbium(III) dota tetraamide complex act as efficient antennae for transfer of magnetization to bulk water
    • SR, Michaudet L, Burgess S, Sherry AD. The amide protons of an ytterbium(III) dota tetraamide complex act as efficient antennae for transfer of magnetization to bulk water. Angew Chem Int Ed Engl 2002; 41: 1919-1921.
    • (2002) Angew Chem Int Ed Engl , vol.41 , pp. 1919-1921
    • R, S.1    Michaudet, L.2    Burgess, S.3    Sherry, A.D.4
  • 72
    • 33750434288 scopus 로고    scopus 로고
    • A PARACEST MRI contrast agent to detect enzyme activity
    • DOI 10.1021/ja063874f
    • Yoo B, Pagel MD. A PARACEST MRI contrast agent to detect enzyme activity. J Am Chem Soc 2006; 128: 14032-14033. (Pubitemid 44657488)
    • (2006) Journal of the American Chemical Society , vol.128 , Issue.43 , pp. 14032-14033
    • Yoo, B.1    Pagel, M.D.2
  • 73
    • 35148833805 scopus 로고    scopus 로고
    • Enzyme-responsive PARACEST MRI contrast agents: A new biomedical imaging approach for studies of the proteasome
    • DOI 10.1002/cmmi.145
    • Yoo B, Raam MS, Rosenblum RM, Pagel MD. Enzyme-responsive PARACEST MRI contrast agents: a new biomedical imaging approach for studies of the proteasome. Contrast Media Mol Imag 2007; 2: 189-198. (Pubitemid 47542595)
    • (2007) Contrast Media and Molecular Imaging , vol.2 , Issue.4 , pp. 189-198
    • Yoo, B.1    Raam, M.S.2    Rosenblum, R.M.3    Pagel, M.D.4
  • 79
    • 36849044069 scopus 로고    scopus 로고
    • Design and characterization of a new irreversible responsive PARACEST MRI contrast agent that detects nitric oxide
    • DOI 10.1002/mrm.21428
    • Liu G, Li Y, Pagel MD. Design and characterization of a new irreversible responsive PARACEST MRI contrast agent that detects nitric oxide. Magn Reson Med 2007; 58: 1249-1256. (Pubitemid 350234212)
    • (2007) Magnetic Resonance in Medicine , vol.58 , Issue.6 , pp. 1249-1256
    • Liu, G.1    Li, Y.2    Pagel, M.D.3
  • 80
    • 67749143924 scopus 로고    scopus 로고
    • A PARACEST agent responsive to innerand outer-sphere phosphate ester interactions for MRI applications
    • Huang C-H, Morrow JR. A PARACEST agent responsive to innerand outer-sphere phosphate ester interactions for MRI applications. J Am Chem Soc 2009; 131: 4206-4207.
    • (2009) J Am Chem Soc , vol.131 , pp. 4206-4207
    • Huang, C.-H.1    Morrow, J.R.2
  • 81
    • 67650698516 scopus 로고    scopus 로고
    • PARACEST properties of a dinuclear neodymium(III) complex bound to DNA or carbonate
    • New K, Andolina CM, Huang C-H, Morrow JR. PARACEST properties of a dinuclear neodymium(III) complex bound to DNA or carbonate. Bioconjug Chem 2009; 20: 1375-1382.
    • (2009) Bioconjug Chem , vol.20 , pp. 1375-1382
    • New, K.1    Andolina, C.M.2    Huang, C.-H.3    Morrow, J.R.4
  • 86
    • 33750319936 scopus 로고    scopus 로고
    • Molecular imaging using a targeted magnetic resonance hyperpolarized biosensor
    • DOI 10.1126/science.1131847
    • Schroder L, Lowery TJ, Hilty C, Wemmer DE, Pines A. Molecular imaging using a targeted magnetic resonance hyperpolarized biosensor. Science 2006; 314: 446-449. (Pubitemid 44628961)
    • (2006) Science , vol.314 , Issue.5798 , pp. 446-449
    • Schroder, L.1    Lowery, T.J.2    Hilty, C.3    Wemmer, D.E.4    Pines, A.5
  • 87
    • 46349087419 scopus 로고    scopus 로고
    • Temperature response of 129Xe depolarization transfer and its application for ultrasensitive NMR detection
    • Schröder L, Meldrum T, Smith M, Lowery TJ, Wemmer DE, Pines A. Temperature response of 129Xe depolarization transfer and its application for ultrasensitive NMR detection. Phys Rev Lett 2008; 100: 257603-257604.
    • (2008) Phys Rev Lett , vol.100 , pp. 257603-257604
    • Schröder, L.1    Meldrum, T.2    Smith, M.3    Lowery, T.J.4    Wemmer, D.E.5    Pines, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.