Bilirubin induces apoptosis via activation of NMDA receptors in developing rat brain neurons

Experimental Neurology

Volumn 166, Issue 2, 2000, Pages 334-341

  Grojean, Stéphanie ^a   Koziel, Violette ^a   Vert, Paul ^a   Daval, Jean Luc ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

Author keywords

Apoptosis; Bilirubin; Caspases; Cultured neurons; Developing rat brain; Glutamate receptors; Protein kinase C; Protein synthesis

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; BILIRUBIN; CASPASE; DIZOCILPINE; FLUORESCENT DYE; GLUTAMATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN KINASE C; THYMIDINE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; BRAIN NERVE CELL; CONTROLLED STUDY; EMBRYO; NEUROTOXICITY; NEWBORN PERIOD; NONHUMAN; PREMATURITY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT;

EID: 0033669937     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7518     Document Type: Article

References (55)

1. Bilirubin inhibits protein kinase C activity and protein kinase C-mediated phosphorylation of endogenous substrates in human skin fibroblasts
2. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
3. Hypoxia/reoxygenation induces apoptosis through biphasic induction of protein synthesis in central neurons
4. CPP32/caspase-3-like proteases in hypoxia-induced apoptosis in developing brain neurons
5. Involvement of caspase-1 proteases in hypoxic brain injury: Effects of their inhibitors in developing neurons
6. A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle of protein-dye binding
7. How bilirubin gets into the brain
8. Bilirubin: Solubility and interaction with albumin and phospholipid
9. The neurotoxicity of bilirubin
10. Lack of correlation between the effects of transient exposure to glutamate and those of hypoxia/reoxygenation in immature neurons in vitro
11. Sequential activation of activator protein-1-related transcription factors and JNK protein kinases may contribute to apoptotic death induced by transient hypoxia in developing brain neurons
12. Glutamate triggers cell death specifically in mature central neurons through a necrotic process
13. Excitotoxic cell death
14. Caspases: The executioners of apoptosis
15. Delayed application of aurintricarboxylic acid reduces glutamate-induced cortical neuronal injury
16. 3H]bilirubin to neurons in rat brain sections
17. Glutamate-induced neuronal death is not a programmed cell death in cerebellar culture
18. An early loss in membrane protein kinase C activity precedes the excitatory amino acid-induced death of primary cortical neurons
19. Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons
20. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
21. Programmed cell death: Necrosis versus apoptosis
22. Neuroprotective action of cycloheximide involves induction of bcl-2 and antioxydant pathways
23. Bilirubin metabolism and kernicterus
24. Neurodevelopment of preterm infants: Neonatal neurosonographic and serum bilirubin studies
25. Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc and actin gene transcription
26. Detection of apoptotic or necrotic death in neuronal cells by morphological, biochemical, and molecular analysis
27. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
28. Bilirubin and brain toxicity
29. Bilirubin has widespread effects on protein phosphorylation
30. The in vivo effect of bilirubin on the N-methyl-D-aspartate receptor/ion channel complex in the brains of newborn piglets
31. 31P nuclear magnetic resonance spectroscopy
32. Characteristic changes of cerebellar proteins associated with cerebellar hypoplasia in jaundiced Gunn rat and the prevention of these by phototherapy
33. Activation of CPP32 during apoptosis of neurons and astrocytes
34. Purification and characterisation of an interleukin-1β-converting enzyme family protease that activates cysteine protease P32 (CPP32)
35. Kernicterus in asphyxiated newborn rhesus monkey
36. Bilirubin
37. Effect of bilirubin on the membrane potential of rat synaptosomes
38. Effect of postnatal anoxia on bilirubin levels in rat brain
39. Role of glutamate receptor mediated excitotoxicity in bilirubin-induced brain injury in the Gunn rat model
40. The end of the (cell) line: Methods for the study of apoptosis in vitro
41. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress
42. Modification of the MTT method for the study of bilirubin cytotoxicity
43. Differential sensitivity of neural cells to bilirubin toxicity
44. Interactions of bilirubin with isolated presynaptic nerve terminals: Functional effects on the uptake and release of neurotransmitters
45. Analysis of glutamate receptors in primary cultured neurons from fetal rat forebrain
46. Enhanced neuronal expression of the oxidoreductase - Biliverdin reductase - After permanent focal cerebral ischemia
47. G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis
48. A system for characterizing cellular and molecular events in programmed neuronal cell death
49. Effects of bilirubin infusion on local cerebral glucose utilization in the immature rat
50. Mode of inhibitory action of bilirubin on protein kinase C
51. Reduction of delayed neuronal death by inhibition of protein synthesis
52. The effects of unconjugated bilirubin and related pigments on cultures of rat cerebellum
53. Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells
54. Mitochondrial respiratory chain inhibitors induce apoptosis
55. Impairment of DNA synthesis in Gunn rat cerebellum