Methotrexate modulates tight junctions through NF-κB, MEK, and JNK Pathways

Journal of Pediatric Gastroenterology and Nutrition

Volumn 54, Issue 4, 2012, Pages 463-470

  Beutheu Youmba, Stéphanie ^a   Belmonte, Liliana ^a   Galas, Ludovic ^a   Boukhettala, Nabile ^a   Bôle Feysot, Christine ^a   Déchelotte, Pierre ^a   Coëffier, Moïse ^a  

^a UNIVERSITÉ DE ROUEN   (France)

Author keywords

chemotherapy; gut barrier; mucositis; signaling pathways; small intestine

Indexed keywords

CLAUDIN 1; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METHOTREXATE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; OCCLUDIN; PROTEIN ZO1; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ELECTRIC RESISTANCE; IN VITRO STUDY; IN VIVO STUDY; INTESTINAL MUCOSITIS; MALE; MICROSCOPY; MODULATION; MONOLAYER CULTURE; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TIGHT JUNCTION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; DEXTRANS; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; INTESTINAL MUCOSA; MALE; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; METHOTREXATE; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; TIGHT JUNCTIONS;

RATTUS;

EID: 84859103181     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0b013e318247240d     Document Type: Article

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