A diet containing whey protein, glutamine, and TGFβ modulates gut protein metabolism during chemotherapy-induced mucositis in rats

Digestive Diseases and Sciences

Volumn 55, Issue 8, 2010, Pages 2172-2181

  Boukhettala, Nabile ^a   Ibrahim, Ayman ^a   Claeyssens, Sophie ^a,b   Faure, Magali ^c   Le Pessot, Florence ^b   Vuichoud, Jacques ^c   Lavoinne, Alain ^a,b   Breuillé, Denis ^c   Déchelotte, Pierre ^a,b   Coëffier, Moïse ^a,b  

^a UNIVERSITÉ DE ROUEN   (France)

^b ROUEN UNIVERSITY HOSPITAL   (France)

^c NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

Chemotherapy; Glutamine; Mucositis; Nutrition; TGF ; Whey proteins

Indexed keywords

ALANINE; CASEIN; GLUTAMINE; GLUTATHIONE; METHOTREXATE; MILK PROTEIN; PLACEBO; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FOOD INTAKE; INTESTINE ABSORPTION; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; RAT;

ANIMALS; BODY WEIGHT; DIET; EATING; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION; GLUTAMINE; INTESTINAL MUCOSA; MALE; MILK PROTEINS; MUCOSITIS; RATS; RATS, SPRAGUE-DAWLEY; TRANSFORMING GROWTH FACTOR BETA;

EID: 77954426094     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-009-1039-2     Document Type: Article

References (37)

1. DM Keefe RJ Gibson 2007 Mucosal injury from targeted anti-cancer therapy Support Care Cancer 15 483 490 10.1007/s00520-006-0181-z 17103195 (Pubitemid 46570783)
2. Logan RM, Stringer AM, Bowen JM, Gibson RJ, Sonis ST, Keefe DM. Serum levels of nf- kappab and pro-inflammatory cytokines following administration of mucotoxic drugs. Cancer Biol Ther. 2008;7.
3. J Leblond F Le Pessot A Hubert-Buron C Duclos J Vuichoud M Faure D Breuille P Dechelotte M Coeffier 2008 Chemotherapy-induced mucositis is associated with changes in proteolytic pathways Exp Biol Med (Maywood) 233 219 228 10.3181/0702-RM-49 1:CAS:528:DC%2BD1cXhsVahu7o%3D (Pubitemid 351231554)
4. N Boukhettala J Leblond S Claeyssens M Faure F Le Pessot C Bole-Feysot A Hassan C Mettraux J Vuichoud A Lavoinne D Breuille P Dechelotte M Coeffier 2009 Methotrexate induces intestinal mucositis and alters gut protein metabolism independently of reduced food intake Am J Physiol Endocrinol Metab 296 E182 E190 10.1152/ajpendo.90459.2008 1:CAS:528:DC%2BD1MXpsFCntA%3D%3D 18984853
5. F Yoshizawa 2004 Regulation of protein synthesis by branched-chain amino acids in vivo Biochem Biophys Res Commun 313 417 422 10.1016/j.bbrc.2003.07.013 1:CAS:528:DC%2BD3sXpvVWmtbY%3D 14684178 (Pubitemid 37543602)
6. A Meister 1994 Glutathione, ascorbate, and cellular protection Cancer Res 54 1969s 1975s 1:CAS:528:DyaK2cXisVSqs7g%3D 8137322 (Pubitemid 24132158)
7. B Sido C Seel A Hochlehnert R Breitkreutz W Droge 2006 Low intestinal glutamine level and low glutaminase activity in crohn's disease. A rational for glutamine supplementation? Dig Dis Sci 51 2170 2179 10.1007/s10620-006-9473-x 1:CAS:528:DC%2BD2sXktFClug%3D%3D 17078002
8. M Coeffier S Claeyssens B Hecketsweiler A Lavoinne P Ducrotte P Dechelotte 2003 Enteral glutamine stimulates protein synthesis and decreases ubiquitin mrna level in human gut mucosa Am J Physiol Gastrointest Liver Physiol 285 G266 G273 1:CAS:528:DC%2BD3sXmsVahtrs%3D 12702496 (Pubitemid 36875197)
9. I Sukhotnik K Khateeb JG Mogilner H Helou M Lurie AG Coran E Shiloni 2007 Dietary glutamine supplementation prevents mucosal injury and modulates intestinal epithelial restitution following ischemia-reperfusion injury in the rat Dig Dis Sci 52 1497 1504 10.1007/s10620-006-9629-8 1:CAS:528: DC%2BD2sXltlaqt78%3D 17404857 (Pubitemid 46776509)
10. M Coeffier R Marion P Ducrotte P Dechelotte 2003 Modulating effect of glutamine on il-1beta-induced cytokine production by human gut Clin Nutr 22 407 413 10.1016/S0261-5614(03)00040-2 1:STN:280:DC%2BD3szkvVKkuw%3D%3D 12880609 (Pubitemid 37063303)
11. H Xue MB Sawyer CJ Field LA Dieleman D Murray VE Baracos 2008 Bolus oral glutamine protects rats against cpt-11-induced diarrhea and differentially activates cytoprotective mechanisms in host intestine but not tumour J Nutr 138 740 746 1:CAS:528:DC%2BD1cXjvValtrY%3D 18356329 (Pubitemid 351469418)
12. B Daniele F Perrone C Gallo S Pignata S De Martino R De Vivo E Barletta R Tambaro R Abbiati L D'Agostino 2001 Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial Gut 48 28 33 10.1136/gut.48.1.28 1:CAS:528: DC%2BD3MXntFKgtQ%3D%3D 11115819 (Pubitemid 32042638)
13. MB Braga-Neto CA Warren RB Oria MS Monteiro AA Maciel GA Brito AA Lima RL Guerrant 2008 Alanyl-glutamine and glutamine supplementation improves 5-fluorouracil-induced intestinal epithelium damage in vitro Dig Dis Sci 53 2687 2696 10.1007/s10620-008-0215-0 1:CAS:528:DC%2BD1cXhtVGnsbjE 18320312
14. MO Li YY Wan S Sanjabi AK Robertson RA Flavell 2006 Transforming growth factor-beta regulation of immune responses Annu Rev Immunol 24 99 146 10.1146/annurev.immunol.24.021605.090737 1:CAS:528:DC%2BD28XkvFSqt7w%3D 16551245
15. I Sukhotnik JG Mogilner R Shaoul R Karry M Lieber E Suss-Toby BM Ure AG Coran 2008 Responsiveness of intestinal epithelial cell turnover to tgf-alpha after bowel resection in a rat is correlated with egf receptor expression along the villus-crypt axis Pediatr Surg Int 24 21 28 10.1007/s00383-007-2038-z 17985142
16. Fell JM, Paintin M, Donnet-Hughes A, Arnaud-Battandier F, MacDonald TT, Walker-Smith JA. Remission induced by a new specific oral polymeric diet in children with crohn's disease. Nestle nutr workshop ser clin perform programme. 1999;2:187-196 (discussion 196-188).
17. PL Beck IM Rosenberg RJ Xavier T Koh JF Wong DK Podolsky 2003 Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells Am J Pathol 162 597 608 1:CAS:528:DC%2BD3sXhtlKqsr4%3D 12547717 (Pubitemid 36267866)
18. M Faure D Moennoz F Montigon C Mettraux D Breuille O Ballevre 2005 Dietary threonine restriction specifically reduces intestinal mucin synthesis in rats J Nutr 135 486 491 1:CAS:528:DC%2BD2MXit12ntrY%3D 15735082 (Pubitemid 40365207)
19. M Coeffier S Claeyssens S Lecleire J Leblond A Coquard C Bole-Feysot A Lavoinne P Ducrotte P Dechelotte 2008 Combined enteral infusion of glutamine, carbohydrates, and antioxidants modulates gut protein metabolism in humans Am J Clin Nutr 88 1284 1290 1:CAS:528:DC%2BD1cXhtlOqu73K 18996864
20. J Leblond A Hubert-Buron C Bole-Feysot P Ducrotte P Dechelotte M Coeffier 2006 Regulation of proteolysis by cytokines in the human intestinal epithelial cell line hct-8: role of ifngamma Biochimie 88 759 765 10.1016/j.biochi.2006.01. 003 1:CAS:528:DC%2BD28Xns12lu70%3D 16488064 (Pubitemid 44142160)
21. CD Tran GS Howarth P Coyle JC Philcox AM Rofe RN Butler 2003 Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine Am J Clin Nutr 77 1296 1303 1:CAS:528:DC%2BD3sXntlamt78%3D 12716685 (Pubitemid 44858449)
22. DM Keefe J Brealey GJ Goland AG Cummins 2000 Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans Gut 47 632 637 10.1136/gut.47.5.632 1:CAS:528:DC%2BD3cXosVSgtbk%3D 11034578
23. RM Logan RJ Gibson JM Bowen AM Stringer ST Sonis DM Keefe 2008 Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis Cancer Chemother Pharmacol 62 33 41 10.1007/s00280-007-0570-0 1:CAS:528:DC%2BD1cXks1Krsb8%3D 17703303 (Pubitemid 351537842)
24. BA Carneiro-Filho IP Lima DH Araujo MC Cavalcante GH Carvalho GA Brito V Lima SM Monteiro FN Santos RA Ribeiro AA Lima 2004 Intestinal barrier function and secretion in methotrexate-induced rat intestinal mucositis Dig Dis Sci 49 65 72 10.1023/B:DDAS.0000011604.45531.2c 1:CAS:528:DC%2BD2cXislegug%3D%3D 14992437 (Pubitemid 38183747)
25. AM Stringer RJ Gibson RM Logan JM Bowen AS Yeoh J Burns DM Keefe 2007 Chemotherapy-induced diarrhea is associated with changes in the luminal environment in the da rat Exp Biol Med (Maywood) 232 96 106 1:CAS:528: DC%2BD2sXmslejtg%3D%3D (Pubitemid 46091606)
26. Tran CD, Sundar S, Howarth GS. Dietary zinc supplementation and methotrexate-induced small intestinal mucositis in metallothionein-knockout and wild-type mice. Cancer Biol Ther 2009;8.
27. Whitford EJ, Cummins AG, Butler RN, Prisciandaro LD, Fauser JK, Yazbeck R, Lawrence A, Cheah KY, Wright TH, Lymn KA, Howarth GS. Effects of streptococcus thermophilus th-4 on intestinal mucositis induced by the chemotherapeutic agent, 5-fluorouracil (5-fu). Cancer Biol Ther. 2009;8.
28. TH Wright R Yazbeck KA Lymn EJ Whitford KY Cheah RN Butler C Feinle-Bisset AN Pilichiewicz S Mashtoub GS Howarth 2009 The herbal extract, iberogast, improves jejunal integrity in rats with 5-fluorouracil (5-fu)-induced mucositis Cancer Biol Ther 8 923 929 19276679
29. K Menzel M Hausmann F Obermeier K Schreiter N Dunger F Bataille W Falk J Scholmerich H Herfarth G Rogler 2006 Cathepsins b, l and d in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo Clin Exp Immunol 146 169 180 10.1111/j.1365-2249.2006.03188.x 1:CAS:528:DC%2BD28XhtF2qsbnL 16968411 (Pubitemid 44393851)
30. KM Bell-McGuinn AL Garfall M Bogyo D Hanahan JA Joyce 2007 Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumour growth and invasiveness in a mouse model of multistage cancer Cancer Res 67 7378 7385 10.1158/0008-5472.CAN-07-0602 1:CAS:528: DC%2BD2sXosVemtL8%3D 17671208 (Pubitemid 47206568)
31. MH Glickman A Ciechanover 2002 The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction Physiol Rev 82 373 428 1:CAS:528:DC%2BD38XjtFOnsL4%3D 11917093 (Pubitemid 34654457)
32. L Belmonte M Coeffier F Le Pessot O Miralles-Barrachina M Hiron A Leplingard JF Lemeland B Hecketsweiler M Daveau P Ducrotte P Dechelotte 2007 Effects of glutamine supplementation on gut barrier, glutathione content and acute phase response in malnourished rats during inflammatory shock World J Gastroenterol 13 2833 2840 1:CAS:528:DC%2BD2sXot1antrg%3D 17569119 (Pubitemid 47007898)
33. DM Savarese G Savy L Vahdat PE Wischmeyer B Corey 2003 Prevention of chemotherapy and radiation toxicity with glutamine Cancer Treat Rev 29 501 513 10.1016/S0305-7372(03)00133-6 1:CAS:528:DC%2BD3sXosVygt7o%3D 14585260 (Pubitemid 37428322)
34. M Cetiner G Sener AO Sehirli E Eksioglu-Demiralp F Ercan S Sirvanci N Gedik S Akpulat T Tecimer BC Yegen 2005 Taurine protects against methotrexate-induced toxicity and inhibits leukocyte death Toxicol Appl Pharmacol 209 39 50 10.1016/j.taap.2005.03.009 1:CAS:528:DC%2BD2MXhtFOhsbfL 15890378 (Pubitemid 41547216)
35. M Dangin Y Boirie C Guillet B Beaufrere 2002 Influence of the protein digestion rate on protein turnover in young and elderly subjects J Nutr 132 3228S 3233S 1:CAS:528:DC%2BD38Xnsl2ktLg%3D 12368423
36. G Schaafsma 2006 Health issues of whey proteins. Protection of lean body mass Curr Topics Nutraceutical Res 4 113 122 1:CAS:528:DC%2BD28XhtVGisrvL (Pubitemid 44463203)
37. S Iyer ZG Wang M Akhtari W Zhao P Seth 2005 Targeting tgf beta signaling for cancer therapy Cancer Biol Ther 4 261 266 1:CAS:528:DC%2BD28XjvFyrtQ%3D%3D 15846079 (Pubitemid 41357481)