Oral insulin enhances cell proliferation and decreases enterocyte apoptosis during methotrexate-induced mucositis in the rat

Journal of Pediatric Gastroenterology and Nutrition

Volumn 47, Issue 2, 2008, Pages 115-122

  Sukhotnik, Igor ^a,b,e   Shehadeh, Naim ^b   Coran, Arnold G ^c   Mogilner, Jorge G ^b   Karry, Rahel ^a   Shamian, Benhoor ^a   Ure, Benno M ^d   Shamir, Raanan ^b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b MEYER CHILDREN S HOSPITAL   (Israel)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d UNIVERSITY OF MICHIGAN   (United States)

^e CS Mott Children's Hospital ^*  (Israel)

Author keywords

Enterocyte apoptosis; Enterocyte proliferation; Methotrexate; Mucositis; Oralinsulin

Indexed keywords

DNA; INSULIN; MESSENGER RNA; METHOTREXATE; PROTEIN BAX; PROTEIN BCL 2; SODIUM CHLORIDE; ANTIDIABETIC AGENT; BAX PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; COMPARATIVE STUDY; CONTROLLED STUDY; CRYPT CELL; EXPERIMENTAL MODEL; ILEUM MUCOSA; INTESTINE CELL; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; INTESTINE MUCOSA; INTESTINE VILLUS; JEJUNUM MUCOSA; MALE; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; SINGLE DRUG DOSE; ANIMAL; CELL DIVISION; CHEMICALLY INDUCED DISORDER; CONVALESCENCE; CYTOLOGY; DRUG EFFECT; METABOLISM; ORAL DRUG ADMINISTRATION; ORGAN SIZE; PATHOLOGY; PROTO ONCOGENE; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALIA; RATTUS;

ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL DIVISION; CELL PROLIFERATION; ENTEROCYTES; GENES, BCL-2; HYPOGLYCEMIC AGENTS; INSULIN; INTESTINAL MUCOSA; MALE; METHOTREXATE; MUCOSITIS; ORGAN SIZE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; RNA, MESSENGER;

EID: 56049097223     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPG.0b013e31806008f1     Document Type: Article

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