Uptake of 3H-1-methyl-4-phenylpyridinium (3H-MPP+) by human intestinal Caco-2 cells is regulated by phosphorylation/dephosphorylation mechanisms

Biochemical Pharmacology

Volumn 63, Issue 8, 2002, Pages 1565-1573

  Martel, Fátima ^a,b   Keating, Elisa ^a   Calhau, Conceição ^b   Azevedo, Isabel ^b  

^a Institute of Pharmacology and Therapeutics   (Portugal)

^b Institute of Pharmacology and Therapeutics   (Portugal)

Author keywords

Apical uptake; Ca2+ calmodulin mediated pathways; Organic cations; Protein kinase A; Protein kinase C

Indexed keywords

CAFFEINE; CALMODULIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; ISOBUTYLMETHYLXANTHINE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MONOAMINE; PROTEIN KINASE C; PYRIDINIUM DERIVATIVE; THEOPHYLLINE;

ARTICLE; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVATION; ENZYME INHIBITION; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; IC 50; INTESTINE ABSORPTION; METABOLISM; PHOSPHORYLATION; PRIORITY JOURNAL; REGULATORY MECHANISM;

1-METHYL-4-PHENYLPYRIDINIUM; ALKALOIDS; BENZOPHENANTHRIDINES; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CALMODULIN; CELL SURVIVAL; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; HERBICIDES; HUMANS; INTESTINES; MITOGEN-ACTIVATED PROTEIN KINASES; PHENANTHRIDINES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; TIME FACTORS; TRITIUM;

EID: 0037090884     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00888-2     Document Type: Article

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