S(+)amphetamine induces a persistent leak in the human dopamine transporter: Molecular stent hypothesis

British Journal of Pharmacology

Volumn 165, Issue 8, 2012, Pages 2749-2757

  Rodriguez Menchaca, Aldo A ^a,b   Solis, Ernesto ^a   Cameron, Krasnodara ^a   De Felice, Louis J ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

Author keywords

Amphetamine; Dopamine; Dopamine transporter; Electrophysiology; Xenopus oocyte expression

Indexed keywords

AMPHETAMINE; COCAINE; DOPAMINE; DOPAMINE TRANSPORTER; SODIUM ION;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOPAMINE RELEASE; DRUG STRUCTURE; FEMALE; INTRACELLULAR TRANSPORT; MOLECULAR BIOLOGY; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ANALYSIS; VOLTAGE CLAMP; XENOPUS LAEVIS;

EID: 84859065347     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01728.x     Document Type: Article

References (52)

1. Amara SG, Sonders MS (1998). Neurotransmitter transporters as molecular targets for addictive drugs. Drug Alcohol Depend 51: 87-96. (Pubitemid 28353758)
2. Burnette WB, Bailey MD, Kukoyi S, Blakely RD, Trowbridge CG, Justice JB Jr (1996). Human norepinephrine transporter kinetics using rotating disk electrode voltammetry. Anal Chem 68: 2932-2938.
3. Carvelli L, McDonald PW, Blakely RD, DeFelice LJ (2004). Dopamine transporters depolarize neurons by a channel mechanism. Proc Natl Acad Sci USA 101: 16046-16051. (Pubitemid 39507924)
4. Carvelli L, Blakely RD, DeFelice LJ (2008). Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission. Proc Natl Acad Sci USA 105: 14192-14197.
5. De Felice LJ (2011). Evaluation of: Piscitelli CL et al. Nature 2010 468: 1129-1132. F1000.com/7439956.
6. DeFelice LJ, Goswami T (2007). Transporters as channels. Annu Rev Physiol 69: 87-112. (Pubitemid 46457637)
7. Erreger K, Grewer C, Javitch JA, Galli A (2008). Currents in response to rapid concentration jumps of amphetamine uncover novel aspects of human dopamine transporter function. J Neurosci 28: 976-989. (Pubitemid 351158997)
8. Falkenburger BH, Barstow KL, Mintz IM (2001). Dendrodendritic inhibition through reversal of dopamine transport. Science 293: 2465-2470. (Pubitemid 32917330)
9. Fischer JF, Cho AK (1979). Chemical release of dopamine from striatal homogenates: evidence for an exchange diffusion model. J Pharmacol Exp Ther 208: 203-209. (Pubitemid 9191709)
10. Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR (2007). New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol 47: 681-698.
11. Furman CA, Chen R, Guptaroy B, Zhang M, Holz RW, Gnegy M (2009). Dopamine and amphetamine rapidly increase dopamine transporter trafficking to the surface: live-cell imaging using total internal reflection fluorescence microscopy. J Neurosci 29: 3328-3336.
12. Galici R, Galli A, Jones DJ, Sanchez TA, Saunders C, Frazer A et al. (2003). Selective decreases in amphetamine self-administration and regulation of dopamine transporter function in diabetic rats. Neuroendocrinology 77: 132-140. (Pubitemid 36302415)
13. Galli A, Petersen CI, deBlaquiere M, Blakely RD, DeFelice LJ (1997). Drosophila serotonin transporters have voltage-dependent uptake coupled to a serotonin-gated ion channel. J Neurosci 17: 3401-3411. (Pubitemid 27200570)
14. Galli A, Blakely RD, DeFelice LJ (1998). Patch-clamp and amperometric recordings from norepinephrine transporters: channel activity and voltage-dependent uptake. Proc Natl Acad Sci USA 95: 13260-13265. (Pubitemid 28509559)
15. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG (1996). Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379: 606-612. (Pubitemid 26052818)
16. Gu H, Caplan MJ, Rudnick G (1998). Cloned catecholamine transporters expressed in polarized epithelial cells: sorting, drug sensitivity, and ion-coupling stoichiometry. Adv Pharmacol 42: 175-179.
17. Ingram SL, Amara SG (2000). Arachidonic acid stimulates a novel cocaine-sensitive cation conductance associated with the human dopamine transporter. J Neurosci 20: 550-557. (Pubitemid 30225557)
18. Ingram SL, Prasad BM, Amara SG (2002). Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons. Nat Neurosci 5: 971-978.
19. Iversen L (2006). Neurotransmitter transporters and their impact on the development of psychopharmacology. Br J Pharmacol 147 (Suppl. 1): S82-S88.
20. -, and pH dependence of the human choline transporter (hCHT) in Xenopus oocytes: the proton inactivation hypothesis of hCHT in synaptic vesicles. J Neurosci 26: 9851-9859.
21. Jones SR, Gainetdinov RR, Wightman RM, Caron MG (1998). Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. J Neurosci 18: 1979-1986. (Pubitemid 28141404)
22. Kahlig KM, Binda F, Khoshbouei H, Blakely RD, McMahon DG, Javitch JA et al. (2005). Amphetamine induces dopamine efflux through a dopamine transporter channel. Proc Natl Acad Sci USA 102: 3495-3500. (Pubitemid 40328073)
23. Khoshbouei H, Wang H, Lechleiter JD, Javitch JA, Galli A (2003). Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanism. J Biol Chem 278: 12070-12077. (Pubitemid 36800184)
24. Machaca K, Hartzell H (1998). Assymetric distribution of Ca-activated Cl channels in Xenopus oocytes. Biophys J 74: 1286-1295. (Pubitemid 28108538)
25. Mofenson HC, Greensher J (1975). Letter: physostigmine as an antidote: use with caution. J Pediatr 87 (6 Pt 1): 1011-1012.
26. Nelson N (1998). The family of Na+/Cl- neurotransmitter transporters. J Neurochem 71: 1785-1803.
27. Nelson N, Sacher A, Nelson H (2002). The significance of molecular slips in transport systems. Nat Rev Mol Cell Biol 3: 876-881. (Pubitemid 35285278)
28. Petersen CI, DeFelice LJ (1999). Ionic interactions in the Drosophila serotonin transporter identify it as a serotonin channel. Nat Neurosci 2: 605-610. (Pubitemid 30491210)
29. Piscitelli CL, Krishnamurthy H, Gouaux E (2010). Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site. Nature 468: 1129-1132.
30. Potkin SG, Karoum F, Chuang LW, Cannon-Spoor HE, Phillips I, Wyatt RJ (1979). Phenylethylamine in paranoid chronic schizophrenia. Science 206: 470-471. (Pubitemid 10191521)
31. Romanelli F, Smith KM (2006). Clinical effects and management of methamphetamine abuse. Pharmacotherapy 26: 1148-1156. (Pubitemid 44167822)
32. Rudnick G (1998a). Bioenergetics of neurotransmitter transport. J Bioenerg Biomembr 30: 173-185.
33. Rudnick G (1998b). Ion-coupled neurotransmitter transport: thermodynamic vs. kinetic determinations of stoichiometry. Methods Enzymol 296: 233-247.
34. Samuvel DJ, Jayanthi LD, Manohar S, Kaliyaperumal K, See RE, Ramamoorthy S (2008). Dysregulation of dopamine transporter trafficking and function after abstinence from cocaine self-administration in rats: evidence for differential regulation in caudate putamen and nucleus accumbens. J Pharmacol Exp Ther 325: 293-301. (Pubitemid 351439183)
35. Saunders C, Ferrer JV, Shi L, Chen J, Merrill G, Lamb ME et al. (2000). Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. Proc Natl Acad Sci USA 97: 6850-6855. (Pubitemid 30412803)
36. Schmitz Y, Lee CJ, Schmauss C, Gonon F, Sulzer D (2001). Amphetamine distorts stimulation-dependent dopamine overflow: effects on D2 autoreceptors, transporters, and synaptic vesicle stores. J Neurosci 21: 5916-5924. (Pubitemid 32737724)
37. Seidel S, Singer EA, Just H, Farhan H, Scholze P, Kudlacek O et al. (2005). Amphetamines take two to tango: an oligomer-based counter-transport model of neurotransmitter transport explores the amphetamine action. Mol Pharmacol 67: 140-151. (Pubitemid 40069974)
38. Seiden LS, Sabol KE, Ricaurte GA (1993). Amphetamine: effects on catecholamine systems and behavior. Annu Rev Pharmacol Toxicol 33: 639-677. (Pubitemid 23116021)
39. Shan J, Javitch JA, Shi L, Weinstein H (2011). The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. PLoS ONE 6: e16350.
40. Shi L, Quick M, Zhao Y, Weinstein H, Javitch JA (2008). The mechanism of a neurotransmitter:sodium symporter-inward release of Na+ and substrate is triggered by substrate in a second binding site. Mol Cell 30: 667-677. (Pubitemid 351815131)
41. Sonders MS, Amara SG (1996). Channels in transporters. Curr Opin Neurobiol 6: 294-302. (Pubitemid 26235676)
42. Sonders MS, Zhu SJ, Zahniser NR, Kavanaugh MP, Amara SG (1997a). Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants. J Neurosci 17: 960-974. (Pubitemid 27043955)
43. Sonders MS, Zhu SJ, Zahniser NR, Kavanaugh MP, Amara SG (1997b). Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants. J Neurosci 17: 960-974. (Pubitemid 27043955)
44. Sulzer D, Galli A (2003). Dopamine transport currents are promoted from curiosity to physiology. Trends Neurosci 26: 173-176. (Pubitemid 36411996)
45. Sulzer D, Maidment NT, Rayport S (1993). Amphetamine and other weak bases act to promote reverse transport of dopamine in ventral midbrain neurons. J Neurochem 60: 527-535. (Pubitemid 23030947)
46. Sulzer D, Chen TK, Lau YY, Kristensen H, Rayport S, Ewing A (1995). Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport. J Neurosci 15: 4102-4108.
47. Verstraete AG (2005). Oral fluid testing for driving under the influence of drugs: history, recent progress and remaining challenges. Forensic Sci Int 150: 143-150.
48. Verstraete AG, Heyden FV (2005). Comparison of the sensitivity and specificity of six immunoassays for the detection of amphetamines in urine. J Anal Toxicol 29: 359-364. (Pubitemid 41191705)
49. Volz TJ, Hanson GR, Fleckenstein AE (2007). The role of the plasmalemmal dopamine and vesicular monoamine transporters in methamphetamine-induced dopaminergic deficits. J Neurochem 101: 883-888. (Pubitemid 46683868)
50. Winslow BT, Voorhees KI, Pehl KA (2007). Methamphetamine abuse. Am Fam Physician 76: 1169-1174.
51. Yamashita A, Singh SK, Kawate T, Jin Y, Gouaux E (2005). Crystal structure of a bacterial homologue of Na+/Cl-dependent neurotransmitter transporters. Nature 437: 215-223. (Pubitemid 41294479)
52. Zhao Y, Terry DS, Shi L, Quick M, Weinstein H, Blanchard SC et al. (2011). Substrate-modulated gating dynamics in a Na(+)-coupled neurotransmitter transporter homologue. Nature 474: 109-1013.