Synthesis and in vitro and in vivo inhibition potencies of highly relevant nerve agent surrogates

Toxicological Sciences

Volumn 126, Issue 2, 2012, Pages 525-533

  Meek, Edward C ^a   Chambers, Howard W ^a,b   Coban, Alper ^a   Funck, Kristen E ^a   Pringle, Ronald B ^a   Ross, Matthew K ^a   Chambers, Janice E ^a  

^a MISSISSIPPI STATE UNIVERSITY   (United States)

^b MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

Acetylcholinesterase; Anticholinesterase; Nerve agent simulant; Nerve agent surrogate; Organophosphate

Indexed keywords

4 NITROPHENYL ETHYL DIMETHYLPHOSPHORAMIDATE; 4 NITROPHENYL ETHYL METHYLPHOSPHONATE; 4 NITROPHENYL ISOPROPYL METHYLPHOSPHONATE; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; CHOLINESTERASE REACTIVATOR; PHTHALIMIDYL ISOPROPYL METHYLPHOSPHONATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; BRAIN; CHOLINESTERASE BLOOD LEVEL; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DIAPHRAGM; DRUG DETERMINATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; ERYTHROCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NEUROPHARMACOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; SKELETAL MUSCLE;

RATTUS;

EID: 84859050276     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs013     Document Type: Article

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