Detection of sarin hydrolysis products from sarin-like organophosphorus agent-exposed human erythrocytes

Journal of Chromatography B: Biomedical Applications

Volumn 701, Issue 1, 1997, Pages 9-17

  Nagao, Masataka ^a   Takatori, Takehiko ^a   Matsuda, Yukimasa ^a   Nakajima, Makoto ^a   Niijima, Hitoshi ^a   Iwase, Hirotaro ^a   Iwadate, Kimiharu ^a   Amano, Toshikimi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Bis(isopropylmethyl)phosphonate; Satin

Indexed keywords

3 [(3 CHOLAMIDOPROPYL)DIMETHYLAMMONIO] 1 PROPANESULFONIC ACID; ACETYLCHOLINESTERASE; ALKALINE PHOSPHATASE; DYFLOS; METHYLPHOSPHONIC ACID; ORGANOPHOSPHORUS COMPOUND; SARIN; TRIMETHYLSILYL DERIVATIVE; TRYPSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG EXPOSURE; DRUG HYDROLYSIS; DRUG POTENCY; ERYTHROCYTE GHOST; ERYTHROCYTE LEVEL; ERYTHROCYTE MEMBRANE; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOAFFINITY CHROMATOGRAPHY; INTOXICATION; INTRAVENOUS DRUG ADMINISTRATION; LD 50; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ACETYLCHOLINESTERASE; ANIMALS; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; DIPHOSPHONATES; ERYTHROCYTES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROLYSIS; LETHAL DOSE 50; MICE; MICE, INBRED BALB C; ORGANOPHOSPHORUS COMPOUNDS; SARIN;

EID: 0030780667     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(97)00355-1     Document Type: Article

References (20)

1. T. Suzuki, H. Morita, K. Ono, K. Maekawa, R. Nagai, Y. Yazaki, Lancet 345 (1995) 980.
2. N. Masuda, M. Takatsu, H. Morinari, T. Ozawa, Lancet 345 (1995) 1446.
3. H. Nozaki, N. Aikawa, Lancet 345 (1995) 1446.
4. D.G. Coe, B.J. Perry, R.K. Brown, J. Chem. Soc., (1957) 3604.
5. G.L. Ellman, K.D. Courtney, V. Andres Jr., R.M. Featherstone, Biochem. Pharmacol. 7 (1961) 88.
6. P.L. Ey, S.J. Prowse, C.R. Jenkin, Immunochemistry 15 (1978) 429.
7. L.M. Gonyea, Clin. Chem. 23 (1977) 234.
8. D.J. Hanahan, J.E. Ekholm, Methods Enzymol. 31 (1974) 168.
9. C.N. Pope, S.S. Padilla, Biochem. Pharmacol. 38 (1989) 181.
10. N. Konno, N. Suzuki, H. Horiguchi, M. Fukushima, Biochem. Pharmacol. 48 (1994) 2073.
11. P.A. D' Agostino, L.J. Provost, J. Chromatogr. 589 (1992) 287.
12. T. Taylor, in A.G. Oilman, T.W. Rall, A.S. Nies and P. Taylor (Editors), Goodman and Gilman's The Pharmacological Basis of Therapeutics, Pergamon Press, New York, 1990, Ch. 7, p. 131.
13. P. Ott, U. Brodbeck, Eur. J. Biochem. 88 (1978) 119.
14. T.A. Dutta-Choudhury, T.L. Rosenberry, J. Biol. Chem. 259 (1984) 5653.
15. W.L. Roberts, B.H. Kim, T.L. Rosenberry, Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 7817.
16. W.L. Roberts, J.J. Myher, A. Kuksis, M.G. Low, T.L. Rosenberry, J. Biol. Chem. 263 (1988) 18766.
17. W.L. Roberts, S. Santikarn, V.N. Reinhold, T.L. Rosenberry, J. Biol. Chem. 263 (1988) 18776.
18. J.L. Sussman, M. Harel, F. Frolow, C. Oefner, A. Goldman, L. Toker, I. Silman, Science 253 (1991) 872.
19. H. Soreq, R. Ben-Aziz, C.A. Prody, S. Seidman, A. Gnatt, L. Neville, J. Lieman-Hurwitz, E. Lev-Lehman, D. Ginzberg, Y. Lapidot-Lifson, H. Zakut, Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 9688.
20. R.M. Black, R.J. Clarke, R.W. Read, M.T.J. Reid, J. Chromatogr. A 662 (1994) 301.