Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents

Journal of Medicinal Chemistry

Volumn 49, Issue 1, 2006, Pages 246-255

  Briseño Roa, Luis ^a   Hill, Jim ^c   Notman, Stuart ^c   Sellers, David ^c   Smith, Andy P ^c   Timperley, Christopher M ^c   Wetherell, Janet ^c   Williams, Nichola H ^c   Williams, Gareth R ^c   Fersht, Alan R ^a   Griffiths, Andrew D ^b  

^a MRC CENTRE FOR PROTEIN ENGINEERING   (United Kingdom)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 CHLORO 7 OXY 4 METHYLCOUMARIN; ARYLDIALKYLPHOSPHATASE; CHOLINESTERASE; COUMARIN DERIVATIVE; CYCLOSARIN; DIMEFOX; DYFLOS; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; ORGANOPHOSPHORUS COMPOUND; PARAOXON; PARATHION; PESTICIDE; PHOSPHOTRIESTERASE; SARIN; SOMAN; TABUN; UNCLASSIFIED DRUG;

ARTICLE; BREVUNDIMONAS DIMINUTA; ENZYME ACTIVITY; ENZYME SYNTHESIS; FLUORESCENCE; HIGH THROUGHPUT SCREENING; IN VIVO STUDY; NONHUMAN; SCREENING; TOXICITY TESTING;

ACETYLCHOLINESTERASE; ANIMALS; ARYLDIALKYLPHOSPHATASE; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; COUMARINS; DRUG EVALUATION, PRECLINICAL; FLUORESCENT DYES; GUINEA PIGS; HYDROLYSIS; KINETICS; MALE; MOLECULAR STRUCTURE; ORGANOPHOSPHORUS COMPOUNDS; ORGANOTHIOPHOSPHORUS COMPOUNDS; PESTICIDES; PHOSPHORIC TRIESTER HYDROLASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 30444457741     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050518j     Document Type: Article

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