메뉴 건너뛰기




Volumn 3, Issue 1, 2012, Pages

Divergence of Rho residue 43 impacts GEF activity

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; ISOLEUCINE; RHO FACTOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; RHOC GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

EID: 84859043541     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: 10.4161/sgtp.19557     Document Type: Article
Times cited : (8)

References (35)
  • 1
    • 0021830154 scopus 로고
    • A novel ras-related gene family
    • PMID:3888408; DOI:10.1016/0092-8674(85)90058-3
    • MadauleP, AxelR. A novel ras-related gene family. Cell1985; 41:31-40; PMID:3888408; DOI:10.1016/0092-8674(85)90058-3.
    • (1985) Cell , vol.41 , pp. 31-40
    • Madaule, P.1    Axel, R.2
  • 2
    • 0842281652 scopus 로고    scopus 로고
    • Rho and Rac take center stage
    • PMID:14744429; DOI:10.1016/S0092-8674(04)00003-0
    • BurridgeK, WennerbergK. Rho and Rac take center stage. Cell2004; 116:167-179; PMID:14744429; DOI:10.1016/S0092-8674(04)00003-0.
    • (2004) Cell , vol.116 , pp. 167-179
    • Burridge, K.1    Wennerberg, K.2
  • 3
    • 2342418629 scopus 로고    scopus 로고
    • Rho-family GTPases: It's not only Rac and Rho (and I like it)
    • PMID:15020670; DOI:10.1242/jcs.01118
    • WennerbergK, DerCJ. Rho-family GTPases: it's not only Rac and Rho (and I like it). J Cell Sci2004; 117:1301-1312; PMID:15020670; DOI:10.1242/jcs.01118.
    • (2004) J Cell Sci , vol.117 , pp. 1301-1312
    • Wennerberg, K.1    Der, C.J.2
  • 4
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: Biochemistry and biology
    • PMID:16212495; DOI:10.1146/annurev.cellbio.21.020604.150721
    • JaffeAB, HallA. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol2005; 21:247-269; PMID:16212495; DOI:10.1146/annurev.cellbio.21.020604.150721.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 5
    • 1642393863 scopus 로고    scopus 로고
    • Molecular basis for Rho GTPase signaling specificity
    • PMID:14999155; DOI:10.1023/B:BREA.0000018427.84929.5c
    • KarnoubAE, SymonsM, CampbellSL, DerCJ. Molecular basis for Rho GTPase signaling specificity. Breast Cancer Res Treat2004; 84:61-71; PMID:14999155; DOI:10.1023/B:BREA.0000018427.84929.5c.
    • (2004) Breast Cancer Res Treat , vol.84 , pp. 61-71
    • Karnoub, A.E.1    Symons, M.2    Campbell, S.L.3    Der, C.J.4
  • 6
    • 6344231714 scopus 로고    scopus 로고
    • Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility
    • PMID:15501444; DOI:10.1016/j.yexcr.2004.08.012
    • WheelerAP, RidleyAJ. Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility. Exp Cell Res2004; 301:43-49; PMID:15501444; DOI:10.1016/j.yexcr.2004.08.012.
    • (2004) Exp Cell Res , vol.301 , pp. 43-49
    • Wheeler, A.P.1    Ridley, A.J.2
  • 7
    • 0035833247 scopus 로고    scopus 로고
    • RhoA is required for monocyte tail retraction during transendothelial migration
    • PMID:11448997; DOI:10.1083/jcb.200103048
    • WorthylakeRA, LemoineS, WatsonJM, BurridgeK. RhoA is required for monocyte tail retraction during transendothelial migration. J Cell Biol2001; 154:147-160; PMID:11448997; DOI:10.1083/jcb.200103048.
    • (2001) J Cell Biol , vol.154 , pp. 147-160
    • Worthylake, R.A.1    Lemoine, S.2    Watson, J.M.3    Burridge, K.4
  • 8
    • 0344758986 scopus 로고    scopus 로고
    • Regulation of cell polarity and protrusion formation by targeting RhoA for degradation
    • PMID:14657501; DOI:10.1126/science.1090772
    • WangHR, ZhangY, OzdamarB, OgunjimiAA, AlexandrovaE, ThomsenGH, et al. Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science2003; 302:1775-1779; PMID:14657501; DOI:10.1126/science.1090772.
    • (2003) Science , vol.302 , pp. 1775-1779
    • Wang, H.R.1    Zhang, Y.2    Ozdamar, B.3    Ogunjimi, A.A.4    Alexandrova, E.5    Thomsen, G.H.6
  • 9
    • 0035523359 scopus 로고    scopus 로고
    • Actin' up: RhoB in cancer and apoptosis
    • PMID:11905808; DOI:10.1038/35101096
    • PrendergastGC. Actin' up: RhoB in cancer and apoptosis. Nat Rev Cancer2001; 1:162-168; PMID:11905808; DOI:10.1038/35101096.
    • (2001) Nat Rev Cancer , vol.1 , pp. 162-168
    • Prendergast, G.C.1
  • 10
    • 67649202158 scopus 로고    scopus 로고
    • Rho isoforms have distinct and specific functions in the process of epithelial to mesenchymal transition in renal proximal tubular cells
    • PMID:19477269; DOI:10.1016/j.cellsig.2009.05.012
    • HutchisonN, HendryBM, SharpeCC. Rho isoforms have distinct and specific functions in the process of epithelial to mesenchymal transition in renal proximal tubular cells. Cell Signal2009; 21:1522-1531; PMID:19477269; DOI:10.1016/j.cellsig.2009.05.012.
    • (2009) Cell Signal , vol.21 , pp. 1522-1531
    • Hutchison, N.1    Hendry, B.M.2    Sharpe, C.C.3
  • 11
    • 0034601487 scopus 로고    scopus 로고
    • Genomic analysis of metastasis reveals an essential role for RhoC
    • PMID:10952316; DOI:10.1038/35020106
    • ClarkEA, GolubTR, LanderES, HynesRO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature2000; 406:532-535; PMID:10952316; DOI:10.1038/35020106.
    • (2000) Nature , vol.406 , pp. 532-535
    • Clark, E.A.1    Golub, T.R.2    Lander, E.S.3    Hynes, R.O.4
  • 12
    • 9244237677 scopus 로고    scopus 로고
    • Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma
    • PMID:15574779; DOI:10.1158/0008-5472.CAN-04-2247
    • SimpsonKJ, DuganAS, MercurioAM. Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma. Cancer Res2004; 64:8694-8701; PMID:15574779; DOI:10.1158/0008-5472.CAN-04-2247.
    • (2004) Cancer Res , vol.64 , pp. 8694-8701
    • Simpson, K.J.1    Dugan, A.S.2    Mercurio, A.M.3
  • 13
    • 24344486013 scopus 로고    scopus 로고
    • RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis
    • PMID:16107613; DOI:10.1101/gad.1310805
    • HakemA, Sanchez-SweatmanO, You-TenA, DuncanG, WakehamA, KhokhaR, et al. RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev2005; 19:1974-1979; PMID:16107613; DOI:10.1101/gad.1310805.
    • (2005) Genes Dev , vol.19 , pp. 1974-1979
    • Hakem, A.1    Sanchez-Sweatman, O.2    You-Ten, A.3    Duncan, G.4    Wakeham, A.5    Khokha, R.6
  • 14
    • 0032563208 scopus 로고    scopus 로고
    • Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules
    • PMID:9668072; DOI:10.1074/jbc.273.30.18943
    • FujisawaK, MadauleP, IshizakiT, WatanabeG, BitoH, SaitoY, et al. Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules. J Biol Chem1998; 273:18943-18949; PMID:9668072; DOI:10.1074/jbc.273.30.18943.
    • (1998) J Biol Chem , vol.273 , pp. 18943-18949
    • Fujisawa, K.1    Madaule, P.2    Ishizaki, T.3    Watanabe, G.4    Bito, H.5    Saito, Y.6
  • 15
    • 0028933716 scopus 로고
    • Ultrastructural localization of ras-related proteins using epitope-tagged plasmids
    • PMID:7537292; DOI:10.1177/43.5.7537292
    • RobertsonD, PatersonHF, AdamsonP, HallA, MonaghanP. Ultrastructural localization of ras-related proteins using epitope-tagged plasmids. J Histochem Cytochem1995; 43:471-480; PMID:7537292; DOI:10.1177/43.5.7537292.
    • (1995) J Histochem Cytochem , vol.43 , pp. 471-480
    • Robertson, D.1    Paterson, H.F.2    Adamson, P.3    Hall, A.4    Monaghan, P.5
  • 16
    • 0035825193 scopus 로고    scopus 로고
    • Differential localization of Rho GTPases in live cells: Regulation by hypervariable regions and RhoGDI binding
    • PMID:11149925; DOI:10.1083/jcb.152.1.111
    • MichaelsonD, SillettiJ, MurphyG, D'EustachioP, RushM, PhilipsMR. Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding. J Cell Biol2001; 152:111-126; PMID:11149925; DOI:10.1083/jcb.152.1.111.
    • (2001) J Cell Biol , vol.152 , pp. 111-126
    • Michaelson, D.1    Silletti, J.2    Murphy, G.3    D'eustachio, P.4    Rush, M.5    Philips, M.R.6
  • 17
    • 0035575585 scopus 로고    scopus 로고
    • Rho family proteins: Coordinating cell responses
    • PMID:11719051; DOI:10.1016/S0962-8924(01)02153-5
    • RidleyAJ. Rho family proteins: coordinating cell responses. Trends Cell Biol2001; 11:471-477; PMID:11719051; DOI:10.1016/S0962-8924(01)02153-5.
    • (2001) Trends Cell Biol , vol.11 , pp. 471-477
    • Ridley, A.J.1
  • 18
    • 0029889591 scopus 로고    scopus 로고
    • Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain
    • PMID:8662891; DOI:10.1074/jbc.271.23.13556
    • ReidT, FuruyashikiT, IshizakiT, WatanabeG, WatanabeN, FujisawaK, et al. Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. J Biol Chem1996; 271:13556-13560; PMID:8662891; DOI:10.1074/jbc.271.23.13556.
    • (1996) J Biol Chem , vol.271 , pp. 13556-13560
    • Reid, T.1    Furuyashiki, T.2    Ishizaki, T.3    Watanabe, G.4    Watanabe, N.5    Fujisawa, K.6
  • 19
    • 0029559573 scopus 로고
    • A novel partner for the GTP-bound forms of rho and rac
    • PMID:8543060; DOI:10.1016/0014-5793(95)01351-2
    • MadauleP, FuruyashikiT, ReidT, IshizakiT, WatanabeG, MoriiN, et al. A novel partner for the GTP-bound forms of rho and rac. FEBS Lett1995; 377:243-248; PMID:8543060; DOI:10.1016/0014-5793(95)01351-2.
    • (1995) FEBS Lett , vol.377 , pp. 243-248
    • Madaule, P.1    Furuyashiki, T.2    Reid, T.3    Ishizaki, T.4    Watanabe, G.5    Morii, N.6
  • 20
    • 79958232399 scopus 로고    scopus 로고
    • RhoA and Rho C have distinct roles in migration and invasion by acting through different targets
    • PMID:21576392; DOI:10.1083/jcb.201011038
    • VegaFM, FruhwirthG, NgT, RidleyAJ. RhoA and Rho C have distinct roles in migration and invasion by acting through different targets. J Cell Biol2011; 193:655-665; PMID:21576392; DOI:10.1083/jcb.201011038.
    • (2011) J Cell Biol , vol.193 , pp. 655-665
    • Vega, F.M.1    Fruhwirth, G.2    Ng, T.3    Ridley, A.J.4
  • 21
    • 79955425392 scopus 로고    scopus 로고
    • A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia
    • PMID:21474314; DOI:10.1016/j.cub.2011.03.039
    • Bravo-CorderoJJ, OserM, ChenX, EddyR, HodgsonL, CondeelisJ. A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Curr Biol2011; 21:635-644; PMID:21474314; DOI:10.1016/j.cub.2011.03.039.
    • (2011) Curr Biol , vol.21 , pp. 635-644
    • Bravo-Cordero, J.J.1    Oser, M.2    Chen, X.3    Eddy, R.4    Hodgson, L.5    Condeelis, J.6
  • 22
    • 77951587879 scopus 로고    scopus 로고
    • Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC
    • PMID:20101212; DOI:10.1038/onc.2009.515
    • KitzingTM, WangY, PertzO, CopelandJW, GrosseR. Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC. Oncogene2010; 29:2441-2448; PMID:20101212; DOI:10.1038/onc.2009.515.
    • (2010) Oncogene , vol.29 , pp. 2441-2448
    • Kitzing, T.M.1    Wang, Y.2    Pertz, O.3    Copeland, J.W.4    Grosse, R.5
  • 23
    • 0036644975 scopus 로고    scopus 로고
    • Guanine nucleotide exchange factors for Rho GTPases: Turning on the switch
    • PMID:12101119; DOI:10.1101/gad.1003302
    • SchmidtA, HallA. Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev2002; 16:1587-1609; PMID:12101119; DOI:10.1101/gad.1003302.
    • (2002) Genes Dev , vol.16 , pp. 1587-1609
    • Schmidt, A.1    Hall, A.2
  • 24
    • 13444252631 scopus 로고    scopus 로고
    • GEF means go: Turning on RHO GTPases with guanine nucleotide-exchange factors
    • PMID:15688002; DOI:10.1038/nrm1587
    • RossmanKL, DerCJ, SondekJ. GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol2005; 6:167-180; PMID:15688002; DOI:10.1038/nrm1587.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 167-180
    • Rossman, K.L.1    Der, C.J.2    Sondek, J.3
  • 25
    • 0036263915 scopus 로고    scopus 로고
    • Structural basis for the selective activation of Rho GTPases by Dbl exchange factors
    • PMID:12006984; DOI:10.1038/nsb796
    • SnyderJT, WorthylakeDK, RossmanKL, BettsL, PruittWM, SiderovskiDP, et al. Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat Struct Biol2002; 9:468-475; PMID:12006984; DOI:10.1038/nsb796.
    • (2002) Nat Struct Biol , vol.9 , pp. 468-475
    • Snyder, J.T.1    Worthylake, D.K.2    Rossman, K.L.3    Betts, L.4    Pruitt, W.M.5    Siderovski, D.P.6
  • 26
    • 8744317101 scopus 로고    scopus 로고
    • Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor
    • PMID:15331592; DOI:10.1074/jbc.M406056200
    • KristellyR, GaoG, TesmerJJ. Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. J Biol Chem2004; 279:47352-47362; PMID:15331592; DOI:10.1074/jbc.M406056200.
    • (2004) J Biol Chem , vol.279 , pp. 47352-47362
    • Kristelly, R.1    Gao, G.2    Tesmer, J.J.3
  • 27
    • 33845933351 scopus 로고    scopus 로고
    • The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF
    • PMID:16954208; DOI:10.1074/jbc.M606220200
    • OleksyA, OpalińskiŁ, DerewendaU, DerewendaZS, OtlewskiJ. The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF. J Biol Chem2006; 281:32891-32897; PMID:16954208; DOI:10.1074/jbc.M606220200.
    • (2006) J Biol Chem , vol.281 , pp. 32891-32897
    • Oleksy, A.1    Opaliński, L.2    Derewenda, U.3    Derewenda, Z.S.4    Otlewski, J.5
  • 28
    • 35948968634 scopus 로고    scopus 로고
    • Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs
    • PMID:18096806; DOI:10.1126/science.1147554
    • Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, et al. Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science2007; 318:1923-1927; PMID:18096806; DOI:10.1126/science.1147554.
    • (2007) Science , vol.318 , pp. 1923-1927
    • Lutz, S.1    Shankaranarayanan, A.2    Coco, C.3    Ridilla, M.4    Nance, M.R.5    Vettel, C.6
  • 29
    • 0037044785 scopus 로고    scopus 로고
    • XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC
    • PMID:12221096; DOI:10.1074/jbc.M207401200
    • ArthurWT, EllerbroekSM, DerCJ, BurridgeK, WennerbergK. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. J Biol Chem2002; 277:42964-42972; PMID:12221096; DOI:10.1074/jbc.M207401200.
    • (2002) J Biol Chem , vol.277 , pp. 42964-42972
    • Arthur, W.T.1    Ellerbroek, S.M.2    Der, C.J.3    Burridge, K.4    Wennerberg, K.5
  • 30
    • 0033081753 scopus 로고    scopus 로고
    • Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
    • PMID:9927417; DOI:10.1093/emboj/18.3.578
    • RenXD, KiossesWB, SchwartzMA. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J1999; 18:578-585; PMID:9927417; DOI:10.1093/emboj/18.3.578.
    • (1999) EMBO J , vol.18 , pp. 578-585
    • Ren, X.D.1    Kiosses, W.B.2    Schwartz, M.A.3
  • 31
    • 0037805583 scopus 로고    scopus 로고
    • Serine phosphorylation negatively regulates RhoA in vivo
    • PMID:12654918; DOI:10.1074/jbc.M213066200
    • EllerbroekSM, WennerbergK, BurridgeK. Serine phosphorylation negatively regulates RhoA in vivo. J Biol Chem2003; 278:19023-19031; PMID:12654918; DOI:10.1074/jbc.M213066200.
    • (2003) J Biol Chem , vol.278 , pp. 19023-19031
    • Ellerbroek, S.M.1    Wennerberg, K.2    Burridge, K.3
  • 32
    • 0028336790 scopus 로고
    • Fluorescent guanine nucleotide analogs and G protein activation
    • PMID:8188654
    • RemmersAE, PosnerR, NeubigRR. Fluorescent guanine nucleotide analogs and G protein activation. J Biol Chem1994; 269:13771-13778; PMID:8188654.
    • (1994) J Biol Chem , vol.269 , pp. 13771-13778
    • Remmers, A.E.1    Posner, R.2    Neubig, R.R.3
  • 33
    • 70349305426 scopus 로고    scopus 로고
    • Specific induction of migration and invasion of pancreatic carcinoma cells by RhoC, which differs from RhoA in its localisation and activity
    • PMID:19642867; DOI:10.1515/BC.2009.110
    • DietrichKA, SchwarzR, LiskaM, GrassS, MenkeA, MeisterM, et al. Specific induction of migration and invasion of pancreatic carcinoma cells by RhoC, which differs from RhoA in its localisation and activity. Biol Chem2009; 390:1063-1077; PMID:19642867; DOI:10.1515/BC.2009.110.
    • (2009) Biol Chem , vol.390 , pp. 1063-1077
    • Dietrich, K.A.1    Schwarz, R.2    Liska, M.3    Grass, S.4    Menke, A.5    Meister, M.6
  • 34
    • 2442702677 scopus 로고    scopus 로고
    • P63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene
    • PMID:15069594; DOI:10.1007/s00210-004-0926-5
    • LutzS, Freichel-BlomquistA, RümenappU, SchmidtM, JakobsKH, WielandT. p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene. Naunyn Schmiedebergs Arch Pharmacol2004; 369:540-546; PMID:15069594; DOI:10.1007/s00210-004-0926-5.
    • (2004) Naunyn Schmiedebergs Arch Pharmacol , vol.369 , pp. 540-546
    • Lutz, S.1    Freichel-Blomquist, A.2    Rümenapp, U.3    Schmidt, M.4    Jakobs, K.H.5    Wieland, T.6
  • 35
    • 0038306871 scopus 로고    scopus 로고
    • A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration
    • PMID:12547822; DOI:10.1074/jbc.M208896200
    • GuoX, StaffordLJ, BryanB, XiaC, MaW, WuX, et al. A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration. J Biol Chem2003; 278:13207-13215; PMID:12547822; DOI:10.1074/jbc.M208896200.
    • (2003) J Biol Chem , vol.278 , pp. 13207-13215
    • Guo, X.1    Stafford, L.J.2    Bryan, B.3    Xia, C.4    Ma, W.5    Wu, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.