Suicide candidate genes associated with bipolar disorder and schizophrenia: An exploratory gene expression profiling analysis of post-mortem prefrontal cortex

BMC Genomics

Volumn 8, Issue , 2007, Pages

  Kim, Sanghyeon ^a   Choi, Kwong Ho ^b   Baykiz, Ali Fuat ^c   Gershenfeld, Howard K ^a,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c Elazig Asker Hast Psikiyat Servisi   (Turkey)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DROSOPHILA PROTEIN; PHOSPHOLIPID SCRAMBLASE 4 PROTEIN; SCRAMBLASE; TRANSCRIPTION FACTOR EMX2; UNCLASSIFIED DRUG;

ADULT; ARTICLE; AUTOPSY; BIPOLAR DISORDER; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; EXPLORATORY RESEARCH; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SCREENING; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; PREFRONTAL CORTEX; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SCHIZOPHRENIA; SUICIDE; CADAVER; DNA MICROARRAY; GENETICS; METABOLISM; METHODOLOGY; MIDDLE AGED;

ADULT; BIPOLAR DISORDER; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POSTMORTEM CHANGES; PREFRONTAL CORTEX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SUICIDE;

EID: 38349169837     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-8-413     Document Type: Article

References (41)

1. McKeown RE Cuffe SP Schulz RM US suicide rates by age group, 1970-2002: an examination of recent trends Am J Public Health 2000, 6 (96-10):1744-1751. 10.2105/AJPH.2005.066951 17008567
2. Chen YW Dilsaver SC Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other Axis I disorders Biol Psychiatry 1996, 39(10):896-899. 10.1016/ 0006-3223(95)00295-2 8860192
3. Oquendo MA Currier D Mann JJ Prospective studies of suicidal behavior in major depressive and bipolar disorders: What is the evidence for predictive risk factors? Acta Psychiatr Scand 2006, 114(3):151-158. 10.1111/j.1600-0447.2006.00829.x 16889585
4. Hawton K Sutton L Haw C Sinclair J Deeks JJ Schizophrenia and suicide: systematic review of risk factors Br J Psychiatry 2005, 187:9-20. 10.1192/bjp.187.1.9 15994566
5. Hawton K Sutton L Haw C Sinclair J Harriss L Suicide and attempted suicide in bipolar disorder: A systematic review of risk factors J Clin Psychiatry 2005, 66(6):693-704. 15960561
6. Maris RW Berman AL Maltsberger JT Summary and conclusions: What have we learned about suicide assessment and prediction? Assessment and prediction of suicide New York, Guilford Press Maris RW, Berman AL, Maltsberger JT, Yufit RI 1992, 640-672.
7. Bunney WE Bunney BG Vawter MP Tomita H Li J Evans SJ Choudary PV Myers RM Jones EG Watson SJ Akil H Microarray technology: A review of new strategies to discover candidate vulnerability genes in psychiatric disorders Am J Psychiatry 2003, 160(4):657-666. 10.1176/ appi.ajp.160.4.657 12668351
8. Mirnics K Levitt P Lewis DA Critical appraisal of DNA microarrays in psychiatric genomics Biol Psychiatry 2006, 60(2):163-176. 16616896
9. Gwadry FG Sequeira A Hoke G Ffrench-Mullen JM Turecki G Molecular characterization of suicide by microarray analysis Am J Med Genet C Semin Med Genet 2005, 133(1):48-56. 15645524
10. Choudary PV Molnar M Evans SJ Tomita H Li JZ Vawter MP Myers RM Bunney WE Jr. Akil H Watson SJ Jones EG Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression Proc Natl Acad Sci U S A 2005, 102(43):15653-15658. 1257393 16230605 10.1073/ pnas.0507901102
11. Sequeira A Gwadry FG Ffrench-Mullen JM Canetti L Gingras Y Casero RA Jr. Rouleau G Benkelfat C Turecki G Implication of SSAT by gene expression and genetic variation in suicide and major depression Arch Gen Psychiatry 2006, 63(1):35-48. 10.1001/archpsyc.63.1.35 16389195
12. Rossner MJ Hirrlinger J Wichert SP Boehm C Newrzella D Hiemisch H Eisenhardt G Stuenkel C von Ahsen O Nave KA Global transcriptome analysis of genetically identified neurons in the adult cortex J Neurosci 2006, 26(39):9956-9966. 10.1523/JNEUROSCI.0468-06.2006 17005859
13. Wei C Li J Bumgarner RE Sample size for detecting differentially expressed genes in microarray experiments BMC Genomics 2004, 5(1):87. 533874 15533245 10.1186/1471-2164-5-87
14. SMRIDB https://www.stanleygenomics.org
15. Higgs BW Elashoff M Richman S Barci B An online database for brain disease research BMC Genomics 2006, 7:70. 1489945 16594998 10.1186/ 1471-2164-7-70
16. Ikeda M Kihara A Igarashi Y Lipid asymmetry of the eukaryotic plasma membrane: Functions and related enzymes Biol Pharm Bull 2006, 29(8):1542-1546. 10.1248/bpb.29.1542 16880601
17. Wiedmer T Zhou Q Kwoh DY Sims PJ Identification of three new members of the phospholipid scramblase gene family Biochim Biophys Acta 2000, 1467(1):244-253. 10.1016/S0005-2736(00)00236-4 10930526
18. Alves ID Salgado GF Salamon Z Brown MF Tollin G Hruby VJ Phosphatidylethanolamine enhances rhodopsin photoactivation and transducin binding in a solid supported lipid bilayer as determined using plasmon-waveguide resonance spectroscopy Biophys J 2005, 88(1):198-210. 1304998 15501933 10.1529/biophysj.104.046722
19. Niu SL Mitchell DC Litman BJ Optimization of receptor-G protein coupling by bilayer lipid composition II: Formation of metarhodopsin II-transducin complex J Biol Chem 2001, 276(46):42807-42811. 10.1074/ jbc.M105778200 11544259
20. Schmidt D Jiang QX MacKinnon R Phospholipids and the origin of cationic gating charges in voltage sensors Nature 2006, 444(7120):775-779. 10.1038/nature05416 17136096
21. Hamasaki T Leingartner A Ringstedt T O'Leary DD EMX2 regulates sizes and positioning of the primary sensory and motor areas in neocortex by direct specification of cortical progenitors Neuron 2004, 43(3):359-372. 10.1016/j.neuron.2004.07.016 15294144
22. Mann JJ Neurobiology of suicidal behaviour Nat Rev Neurosci 2003, 4(10):819-828. 10.1038/nrn1220 14523381
23. Sibille E Arango V Galfalvy HC Pavlidis P Erraji-Benchekroun L Ellis SP John Mann J Gene expression profiling of depression and suicide in human prefrontal cortex Neuropsychopharmacology 2004, 29(2):351-361. 10.1038/ sj.npp.1300335 14603265
24. Willour VL Zandi PP Badner JA Steele J Miao K Lopez V Mackinnon DF Mondimore FM Schweizer B McInnis MG Miller EB Depaulo JR Jr. Gershon ES McMahon FJ Potash JB Attempted Suicide in Bipolar Disorder Pedigrees: Evidence for Linkage to 2p12 Biol Psychiatry 2007, 61(5):725-727. 10.1016/j.biopsych.2006.05.014 17046723
25. Cheng R Juo SH Loth JE Nee J Iossifov I Blumenthal R Sharpe L Kanyas K Lerer B Lilliston B Smith M Trautman K Gilliam TC Endicott J Baron M Genome-wide linkage scan in a large bipolar disorder sample from the National Institute of Mental Health genetics initiative suggests putative loci for bipolar disorder, psychosis, suicide, and panic disorder Mol Psychiatry 2006, 11(3):252-260. 10.1038/sj.mp.4001778 16402137
26. Prabakaran S Swatton JE Ryan MM Huffaker SJ Huang JT Griffin JL Wayland M Freeman T Dudbridge F Lilley KS Karp NA Hester S Tkachev D Mimmack ML Yolken RH Webster MJ Torrey EF Bahn S Mitochondrial dysfunction in schizophrenia: Evidence for compromised brain metabolism and oxidative stress Mol Psychiatry 2004, 9(7): 684-97, 643. 10.1038/sj.mp.4001532 15098003
27. Iwamoto K Kakiuchi C Bundo M Ikeda K Kato T Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders Mol Psychiatry 2004, 9(4):406-416. 10.1038/sj.mp.4001437 14743183
28. Raust A Slama F Mathieu F Roy I Chenu A Koncke D Fouques D Jollant F Jouvent E Courtet P Leboyer M Bellivier F Prefrontal cortex dysfunction in patients with suicidal behavior Psychol Med 2007, 37(3):411-419. 10.1017/S0033291706009111 17049103
29. Zermatten A Van der Linden M d'Acremont M Jermann F Bechara A Impulsivity and decision making J Nerv Ment Dis 2005, 193(10):647-650. 10.1097/01.nmd.0000180777.41295.65 16208159
30. BRB array tool http://linus.nci.nih.gov/BRB-ArrayTools.html
31. Benjamini Y Hochberg Y Controlling the False Discovery Rate: A practical and powerful approach to multiple testing J Royal Stat Soc Ser B 1995, 57(1):289-300.
32. Hamatani T Daikoku T Wang H Matsumoto H Carter MG Ko MS Dey SK Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation Proc Natl Acad Sci U S A 2004, 101(28):10326-10331. 478571 15232000 10.1073/pnas.0402597101
33. Raponi M Belly RT Karp JE Lancet JE Atkins D Wang Y Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia BMC Cancer 2004, 4:56. 516036 15329151 10.1186/1471-2407-4-56
34. Peirson SN Butler JN Foster RG Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis Nucleic Acids Res 2003, 31(14):e73. 167648 12853650 10.1093/nar/gng073
35. Yuan JS Reed A Chen F Stewart CN Jr. Statistical analysis of real-time PCR data BMC Bioinformatics 2006, 7:85. 1395339 16504059 10.1186/ 1471-2105-7-85
36. Ruxton GD The unequal variance t-test is an underused alternative to Student's t-test and the Mann-Whitney U test Behav Ecol 2006, 17(4):688-690. 10.1093/beheco/ark016
37. Livak KJ Schmittgen TD Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 2001, 25(4):402-408. 10.1006/meth.2001.1262 11846609
38. DAVID integrated database query tool http://david.abcc.ncifcrf.gov/
39. Dennis G Jr. Sherman BT Hosack DA Yang J Gao W Lane HC Lempicki RA DAVID: Database for Annotation, Visualization, and Integrated Discovery Genome Biol 2003, 4(5):P3. 10.1186/gb-2003-4-5-p3 12734009
40. Gene Ontology Consortium http://www.geneontology.org
41. Ingenuity Pathways Analysis http://www.Ingenuity.com