Are rat results from intratracheal instillation of 19 granular dusts a reliable basis for predicting cancer risk?

Regulatory Toxicology and Pharmacology

Volumn 54, Issue 1, 2009, Pages 72-83

  Valberg, P A ^a   Bruch, J ^b,c   McCunney, R J ^d  

^a GRADIENT   (United States)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c MARL   (Germany)

^d Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Airborne dust; Dose extrapolation; Insoluble particles; Intratracheal instillation; Low toxicity; Lung cancer; Particle inhalation; Rat lung tumors

Indexed keywords

ALUMINUM OXIDE; ALUMINUM SILICATE; COAL; KAOLIN; SILICON DIOXIDE; TITANIUM DIOXIDE;

AIRBORNE PARTICLE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER MODEL; CANCER RISK; CONTROLLED STUDY; DOSE RESPONSE; DUST EXPOSURE; FEMALE; LUNG CANCER; LUNG CARCINOGENESIS; NONHUMAN; OCCUPATIONAL EXPOSURE; PARTICLE SIZE; PREDICTION; PRIORITY JOURNAL; RAT; RISK ASSESSMENT;

AIR POLLUTANTS; AIR POLLUTANTS, OCCUPATIONAL; ANIMALS; CARCINOGENICITY TESTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DUST; FEMALE; HUMANS; INTUBATION, INTRATRACHEAL; LUNG NEOPLASMS; OCCUPATIONAL EXPOSURE; PARTICLE SIZE; PNEUMOCONIOSIS; PNEUMONIA; PREDICTIVE VALUE OF TESTS; RATS; RISK ASSESSMENT; SOLUBILITY; SPECIES SPECIFICITY; VEHICLE EMISSIONS;

RATTUS;

EID: 67349116785     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2009.02.008     Document Type: Article

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