-
1
-
-
73549109887
-
Is the prevalence of asthma declining? Systematic review of epidemiological studies
-
Anandan C, Nurmatov U, van Schayck OC, Sheikh A. Is the prevalence of asthma declining? Systematic review of epidemiological studies. Allergy 2010;65(2):152-67
-
(2010)
Allergy
, vol.65
, Issue.2
, pp. 152-167
-
-
Anandan, C.1
Nurmatov, U.2
Van Schayck, O.C.3
Sheikh, A.4
-
2
-
-
79959334504
-
Pathophysiology of allergic inflammation
-
Barnes PJ. Pathophysiology of allergic inflammation. Immunol Rev 2011;242(1):31-50
-
(2011)
Immunol Rev
, vol.242
, Issue.1
, pp. 31-50
-
-
Barnes, P.J.1
-
3
-
-
14744285888
-
Histone acetylation and deacetylation: Importance in inflammatory lung diseases
-
DOI 10.1183/09031936.05.00117504
-
Barnes PJ, Adcock IM, Ito K. Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur Respir J 2005;25:552-63 (Pubitemid 40331188)
-
(2005)
European Respiratory Journal
, vol.25
, Issue.3
, pp. 552-563
-
-
Barnes, P.J.1
Adcock, I.M.2
Ito, K.3
-
4
-
-
44049085594
-
New approaches to managing asthma: A US perspective
-
Berger WE. New approaches to managing asthma: a US perspective. Ther Clin Risk Manag 2008;4:363-79 (Pubitemid 351711996)
-
(2008)
Therapeutics and Clinical Risk Management
, vol.4
, Issue.2
, pp. 363-379
-
-
Berger, W.E.1
-
6
-
-
33749436104
-
Targeting airway inflammation: Novel therapies for the treatment of Asthma
-
DOI 10.2174/092986706778521779
-
Walsh GM. Targeting airway inflammation: novel therapies for the treatment of asthma. Curr Med Chem 2006;13:3105-11 (Pubitemid 44509711)
-
(2006)
Current Medicinal Chemistry
, vol.13
, Issue.25
, pp. 3105-3111
-
-
Walsh, G.M.1
-
7
-
-
80053330950
-
Novel cytokine-directed therapies for asthma
-
Walsh GM. Novel cytokine-directed therapies for asthma. Discov Med 2011;11(59):283-91
-
(2011)
Discov Med
, vol.11
, Issue.59
, pp. 283-291
-
-
Walsh, G.M.1
-
9
-
-
71949107298
-
Mepolizumab and eosinophil-mediated disease
-
Walsh GM. Mepolizumab and eosinophil-mediated disease. Curr Med Chem 2009;16:4774-8
-
(2009)
Curr Med Chem
, vol.16
, pp. 4774-4778
-
-
Walsh, G.M.1
-
10
-
-
61849086181
-
Mepolizumab and exacerbations of refractory eosinophilic asthma
-
This trial used patients with sputum eosinophilia whose asthma symptoms were refractory to high-dose GCs and who had greater than two exacerbations requiring oral GCs during the previous 12 months. The primary end point was the number of severe exacerbations per patient; secondary outcomes included asthma symptoms, HRQoL measured with the AQLQ, lung function, AHR and blood or sputum eosinophil count. Compared with placebo (n = 32), mepolizumab treatment (n = 29) resulted in a significant reduction in blood and sputum eosinophil numbers, with fewer severe exacerbations per patient compared with placebo, together with a significant improvement in HRQoL
-
Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009;360:973-84 This trial used patients with sputum eosinophilia whose asthma symptoms were refractory to high-dose GCs and who had greater than two exacerbations requiring oral GCs during the previous 12 months. The primary end point was the number of severe exacerbations per patient; secondary outcomes included asthma symptoms, HRQoL measured with the AQLQ, lung function, AHR and blood or sputum eosinophil count. Compared with placebo (n = 32), mepolizumab treatment (n = 29) resulted in a significant reduction in blood and sputum eosinophil numbers, with fewer severe exacerbations per patient compared with placebo, together with a significant improvement in HRQoL.
-
(2009)
N Engl J Med
, vol.360
, pp. 973-984
-
-
Haldar, P.1
Brightling, C.E.2
Hargadon, B.3
-
11
-
-
61849155730
-
Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
-
Patients (n = 9 active, 11 placebo) with a history of exacerbations exhibited persistent sputum eosinophilia despite requiring oral prednisone for control of asthma symptoms. In the mepolizumab-treated group, 1 patient had an exacerbation compared with 12 exacerbations in the placebo group. Mepolizumab treatment significantly reduced sputum and blood eosinophil counts to normal values, yielded a significant reduction in the oral prednisone dose, a modest improvement in FEV1 (mean = 300 ml), significant improvement in scores on the Juniper Asthma Control Questionnaire (p = 0.01) and significant improvement in HRQoL with no significant side effects reported
-
Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009;360:985-93 Patients (n = 9 active, 11 placebo) with a history of exacerbations exhibited persistent sputum eosinophilia despite requiring oral prednisone for control of asthma symptoms. In the mepolizumab-treated group, 1 patient had an exacerbation compared with 12 exacerbations in the placebo group. Mepolizumab treatment significantly reduced sputum and blood eosinophil counts to normal values, yielded a significant reduction in the oral prednisone dose, a modest improvement in FEV1 (mean = 300 ml), significant improvement in scores on the Juniper Asthma Control Questionnaire (p = 0.01) and significant improvement in HRQoL with no significant side effects reported.
-
(2009)
N Engl J Med
, vol.360
, pp. 985-993
-
-
Nair, P.1
Pizzichini, M.M.2
Kjarsgaard, M.3
-
12
-
-
77952737931
-
Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndrome
-
Kim S, Marigowda G, Oren E, et al. Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndrome. J Allergy Clin Immunol 2010;125:1336-43
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 1336-1343
-
-
Kim, S.1
Marigowda, G.2
Oren, E.3
-
13
-
-
73149102339
-
Sustained response to mepolizumab in refractory Churg-Strauss syndrome
-
Kahn JE, Grandpeix-Guyodo C, Marroun I, et al. Sustained response to mepolizumab in refractory Churg-Strauss syndrome. J Allergy Clin Immunol 2010;125:267-70
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 267-270
-
-
Kahn, J.E.1
Grandpeix-Guyodo, C.2
Marroun, I.3
-
14
-
-
81455155725
-
Reslizumab for poorly controlled, eosinophilic asthma: A randomized, placebo-controlled study
-
for the Res-5-0010 Study Group Epub ahead of print
-
Castro M, Mathur S, Hargreave F, for the Res-5-0010 Study Group. Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med 2011; [Epub ahead of print]
-
(2011)
Am J Respir Crit Care Med
-
-
Castro, M.1
Mathur, S.2
Hargreave, F.3
-
15
-
-
67650245693
-
Reslizumab, a humanized monoclonal anti-IL-5 antibody for the treatment of eosinophil-mediated inflammatory conditions
-
Walsh GM. Reslizumab, a humanized monoclonal anti-IL-5 antibody for the treatment of eosinophil-mediated inflammatory conditions. Curr Opin Mol Ther 2009;11:329-36
-
(2009)
Curr Opin Mol Ther
, vol.11
, pp. 329-336
-
-
Walsh, G.M.1
-
16
-
-
77952733788
-
MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function
-
Kolbeck R, Kozhich A, Koike M, et al. MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol 2010;125:1344-53.e2
-
(2010)
J Allergy Clin Immunol
, vol.125
-
-
Kolbeck, R.1
Kozhich, A.2
Koike, M.3
-
17
-
-
77952683218
-
Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti - IL-5 receptor antibody, in a phase I study of subjects with mild asthma
-
An open-label clinical trial demonstrating that single, escalating doses of benralizumab had a reasonable safety profile and resulted in marked reduction of peripheral blood eosinophil counts in patients with mild allergic asthma within 24 h of administration
-
Busse WW, Katial R, Gossage D, et al. Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti - IL-5 receptor antibody, in a phase I study of subjects with mild asthma. J Allergy Clin Immunol 2010;125:1237-44 An open-label clinical trial demonstrating that single, escalating doses of benralizumab had a reasonable safety profile and resulted in marked reduction of peripheral blood eosinophil counts in patients with mild allergic asthma within 24 h of administration.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 1237-1244
-
-
Busse, W.W.1
Katial, R.2
Gossage, D.3
-
19
-
-
70049100374
-
Innate cells and T helper 2 cell immunity in airway inflammation
-
Barrett NA, Austen KF. Innate cells and T helper 2 cell immunity in airway inflammation. Immunity 2009;31(3):425-37
-
(2009)
Immunity
, vol.31
, Issue.3
, pp. 425-437
-
-
Barrett, N.A.1
Austen, K.F.2
-
20
-
-
0032545213
-
Interleukin-13: Central mediator of allergic asthma
-
Wills-Karp M, Luyimbazi J, Xu X, et al. Interleukin-13: central mediator of allergic asthma. Science 1998;282:2258-60
-
(1998)
Science
, vol.282
, pp. 2258-2260
-
-
Wills-Karp, M.1
Luyimbazi, J.2
Xu, X.3
-
21
-
-
1642545168
-
IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle
-
DOI 10.1038/sj.bjp.0705558
-
Tliba O, Deshpande D, Chen H, et al. IL-13 enhances agonist evoked calcium signals and contractile responses in airway smooth muscle. Br J Pharmacol 2003;140:1159-62 (Pubitemid 38117418)
-
(2003)
British Journal of Pharmacology
, vol.140
, Issue.7
, pp. 1159-1162
-
-
Tliba, O.1
Deshpande, D.2
Chen, H.3
Van Besien, C.4
Kannan, M.5
Panettieri Jr., R.A.6
Amrani, Y.7
-
22
-
-
3042795833
-
Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: Role of CD38/cyclic adenosine diphosphate ribose pathway
-
DOI 10.1165/rcmb.2003-0313OC
-
Deshpande DA, Dogan S, Walseth TF, et al. Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway. Am J Respir Cell Mol Biol 2004;31:36-42 (Pubitemid 38888037)
-
(2004)
American Journal of Respiratory Cell and Molecular Biology
, vol.31
, Issue.1
, pp. 36-42
-
-
Deshpande, D.A.1
Dogan, S.2
Walseth, T.F.3
Miller, S.M.4
Amrani, Y.5
Panettieri, R.A.6
Kannan, M.S.7
-
23
-
-
59149107299
-
Interleukin-13 Augments Bronchial Smooth Muscle Contractility with an Upregulation of RhoA Protein
-
Chiba Y, Nakazawa S, Todoroki M, et al. Interleukin-13 Augments Bronchial Smooth Muscle Contractility with an Upregulation of RhoA Protein. Am J Respir Cell Mol Biol 2009;40(2):159-67
-
(2009)
Am J Respir Cell Mol Biol
, vol.40
, Issue.2
, pp. 159-167
-
-
Chiba, Y.1
Nakazawa, S.2
Todoroki, M.3
-
24
-
-
0036344597
-
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
-
Kuperman DA, Huang X, Koth LL, et al. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002;8:885-9
-
(2002)
Nat Med
, vol.8
, pp. 885-889
-
-
Kuperman, D.A.1
Huang, X.2
Koth, L.L.3
-
26
-
-
40049099397
-
Increased sputum and bronchial biopsy IL-13 expression in severe asthma
-
DOI 10.1016/j.jaci.2008.01.005, PII S0091674908001267
-
Berry MA, Parker D, Neale N, et al. Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis. J Allergy Clin Immunol 2004;114:1106-927. Saha SK, Berry MA, Parker D, et al. Increased sputum and bronchial biopsy IL-13 expression in severe asthma. J Allergy Clin Immunol 2008;121:685-91 (Pubitemid 351323866)
-
(2008)
Journal of Allergy and Clinical Immunology
, vol.121
, Issue.3
, pp. 685-691
-
-
Saha, S.K.1
Berry, M.A.2
Parker, D.3
Siddiqui, S.4
Morgan, A.5
May, R.6
Monk, P.7
Bradding, P.8
Wardlaw, A.J.9
Pavord, I.D.10
Brightling, C.E.11
-
27
-
-
0346216118
-
Interleukin-4 and -13 expression is co-localized to mast cells within the airway smooth muscle in asthma
-
DOI 10.1111/j.1365-2222.2003.01827.x
-
Brightling CE, Symon FA, Holgate ST, et al. Interleukin-4 and -13 expression is co-localized to mast cells within the airway smooth muscle in asthma. Clin Exp Allergy 2003;33:1711-16 (Pubitemid 38005392)
-
(2003)
Clinical and Experimental Allergy
, vol.33
, Issue.12
, pp. 1711-1716
-
-
Brightling, C.E.1
Symon, F.A.2
Holgate, S.T.3
Wardlaw, A.J.4
Pavord, I.D.5
Bradding, P.6
-
28
-
-
0036088040
-
IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle
-
Grunstein MM, Hakonarson H, Leiter J, et al. IL-13-dependent autocrine signaling mediates altered responsiveness of IgE sensitized airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2002;282:L520-8 (Pubitemid 34654657)
-
(2002)
American Journal of Physiology - Lung Cellular and Molecular Physiology
, vol.282
, Issue.3
-
-
Grunstein, M.M.1
Hakonarson, H.2
Leiter, J.3
Chen, M.4
Whelan, R.5
Grunstein, J.S.6
Chuang, S.7
-
29
-
-
76149118421
-
Has the time come to rethink the pathogenesis of asthma?
-
Holgate ST. Has the time come to rethink the pathogenesis of asthma? Curr Opin Allergy Clin Immunol 2010;10(1):48-53
-
(2010)
Curr Opin Allergy Clin Immunol
, vol.10
, Issue.1
, pp. 48-53
-
-
Holgate, S.T.1
-
30
-
-
0036081034
-
Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells
-
Danahay H, Atherton H, Jones G, et al. Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells. Am J Physiol Lung Cell MolPhysiol 2002;282:L226-36 (Pubitemid 34654674)
-
(2002)
American Journal of Physiology - Lung Cellular and Molecular Physiology
, vol.282
, Issue.2
-
-
Danahay, H.1
Atherton, H.2
Jones, G.3
Bridges, R.J.4
Poll, C.T.5
-
31
-
-
0035665517
-
Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-gamma
-
Ahdieh M, Vandenbos T, Youakim A. Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-gamma. Am J Physiol Cell Physiol 2001;281:C2029-38
-
(2001)
Am J Physiol Cell Physiol
, vol.281
-
-
Ahdieh, M.1
Vandenbos, T.2
Youakim, A.3
-
32
-
-
0032875377
-
Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
-
Wenzel SE, Schwartz LB, Langmac EL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999;160:1001-8 (Pubitemid 29442043)
-
(1999)
American Journal of Respiratory and Critical Care Medicine
, vol.160
, Issue.3
, pp. 1001-1008
-
-
Wenzel, S.E.1
Schwartz, L.B.2
Langmack, E.L.3
Halliday, J.L.4
Trudeau, J.B.5
Gibbs, R.L.6
Chu, H.W.7
-
33
-
-
0035006390
-
2-terminal kinase-dependent pathway
-
DOI 10.1067/mai.2001.114702
-
Hashimoto S, Gon Y, Takeshita I, et al. IL-4 and IL-13 induce myofibroblastic phenotype of human lung fibroblasts through c-Jun NH2-terminal kinase-dependent pathway. J Allergy Clin Immunol 2001;107:1001-8 (Pubitemid 32523339)
-
(2001)
Journal of Allergy and Clinical Immunology
, vol.107
, Issue.6
, pp. 1001-1008
-
-
Hashimoto, S.1
Gon, Y.2
Takeshita, I.3
Maruoka, S.4
Horie, T.5
-
34
-
-
54949149215
-
Therapeutics targeting IL-13 for the treatment of pulmonary inflammation and airway remodeling
-
Blease K. Therapeutics targeting IL-13 for the treatment of pulmonary inflammation and airway remodeling. Curr Opin Investig Drugs 2008;9:1180-4
-
(2008)
Curr Opin Investig Drugs
, vol.9
, pp. 1180-1184
-
-
Blease, K.1
-
35
-
-
80053084755
-
Lebrikizumab treatment in adults with asthma
-
Epub ahead of print This clinical trial with the anti-IL-13 biologic lebrikizumab in patients with uncontrolled asthma despite inhaled GC therapy reported that patients with high pretreatment levels of serum periostin, a cellular matrix protein that is released by airway epithelial cells stimulated with IL-13, had greater and significant improvement in lung function following lebrikizumab treatment than did patients with low periostin levels
-
Corren J, Lemanske RF, Hanania NA, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011; [Epub ahead of print] This clinical trial with the anti-IL-13 biologic lebrikizumab in patients with uncontrolled asthma despite inhaled GC therapy reported that patients with high pretreatment levels of serum periostin, a cellular matrix protein that is released by airway epithelial cells stimulated with IL-13, had greater and significant improvement in lung function following lebrikizumab treatment than did patients with low periostin levels.
-
(2011)
N Engl J Med
-
-
Corren, J.1
Lemanske, R.F.2
Hanania, N.A.3
-
36
-
-
77956289251
-
Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production and collagen gel elasticity in asthma
-
Sidhu SS, Yuan S, Innes AL, et al. Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production and collagen gel elasticity in asthma. Proc Natl Acad Sci USA 2010;107:14170-5
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 14170-14175
-
-
Sidhu, S.S.1
Yuan, S.2
Innes, A.L.3
-
37
-
-
33745394558
-
Periostin: A novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals
-
DOI 10.1016/j.jaci.2006.02.046, PII S0091674906006440
-
Takayama G, Arima K, Kanaji T, et al. Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals. J Allergy Clin Immunol 2006;118:98-104 (Pubitemid 43946467)
-
(2006)
Journal of Allergy and Clinical Immunology
, vol.118
, Issue.1
, pp. 98-104
-
-
Takayama, G.1
Arima, K.2
Kanaji, T.3
Toda, S.4
Tanaka, H.5
Shoji, S.6
McKenzie, A.N.J.7
Nagai, H.8
Hotokebuchi, T.9
Izuhara, K.10
-
38
-
-
58149232415
-
Emerging drugs for asthma
-
Walsh GM. Emerging drugs for asthma. Expert Opin Emerg Drugs 2008;13:643-53
-
(2008)
Expert Opin Emerg Drugs
, vol.13
, pp. 643-653
-
-
Walsh, G.M.1
-
39
-
-
84859954635
-
Inhaled pitrakinra, an IL-4/IL- 13 antagonist, reduced exacerbations in patients with eosinophilic asthma
-
abstract #P3980
-
Wenzel SE, Ind PW, Otulana BA, et al. Inhaled pitrakinra, an IL-4/IL- 13 antagonist, reduced exacerbations in patients with eosinophilic asthma. Ann Cong Eur Resp Soc 2010;36:abstract #P3980
-
(2010)
Ann Cong Eur Resp Soc
, vol.36
-
-
Wenzel, S.E.1
Ind, P.W.2
Otulana, B.A.3
-
40
-
-
77953039047
-
A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma
-
Corren J, Busse W, Meltzer EO, et al. A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma. Am J Respir Crit Care Med 2010;181(8):788-96
-
(2010)
Am J Respir Crit Care Med
, vol.181
, Issue.8
, pp. 788-796
-
-
Corren, J.1
Busse, W.2
Meltzer, E.O.3
-
41
-
-
38149091442
-
Targeting TNF-alpha: A novel therapeutic approach for asthma
-
Brightling C, Berry M, Amrani Y. Targeting TNF-alpha: a novel therapeutic approach for asthma. J Allergy Clin Immunol 2008;121:5-10
-
(2008)
J Allergy Clin Immunol
, vol.121
, pp. 5-10
-
-
Brightling, C.1
Berry, M.2
Amrani, Y.3
-
42
-
-
62549084077
-
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma
-
This clinical trial with the anti-TNF-a biologic golimumab in patients with severe uncontrolled persistent asthma reported negative clinical findings. Importantly, this trial was terminated early due to unacceptable adverse events, including frequent serious infections and eight malignancies in the active-treatment group compared with the placebo group
-
Wenzel SE, Barnes PJ, Bleecker ER, et al. A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med 2009;179(7):549-58 This clinical trial with the anti-TNF-a biologic golimumab in patients with severe uncontrolled persistent asthma reported negative clinical findings. Importantly, this trial was terminated early due to unacceptable adverse events, including frequent serious infections and eight malignancies in the active-treatment group compared with the placebo group.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, Issue.7
, pp. 549-558
-
-
Wenzel, S.E.1
Barnes, P.J.2
Bleecker, E.R.3
-
43
-
-
75749095929
-
TNF-alpha inhibitors in asthma and COPD: We must not throw the baby out with the bath water
-
Matera MG, Calzetta L, Cazzola M. TNF-alpha inhibitors in asthma and COPD: we must not throw the baby out with the bath water. Pulm Pharmacol Ther 2010;23(2):121-8
-
(2010)
Pulm Pharmacol Ther
, vol.23
, Issue.2
, pp. 121-128
-
-
Matera, M.G.1
Calzetta, L.2
Cazzola, M.3
-
44
-
-
77956623567
-
A look at the pathogenesis of asthma: The need for a change in direction
-
Holgate ST. A look at the pathogenesis of asthma: the need for a change in direction. Discov Med 2010;9(48):439-47
-
(2010)
Discov Med
, vol.9
, Issue.48
, pp. 439-447
-
-
Holgate, S.T.1
|