Toxic effects of expanded ataxin-1 involve mechanical instability of the nuclear membrane

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1822, Issue 6, 2012, Pages 906-917

  Mapelli, Lisa ^a   Canale, Claudio ^b   Pesci, Daniela ^c   Averaimo, Stefania ^a   Guizzardi, Fabiana ^a,g   Fortunati, Valentina ^c   Falasca, Laura ^d   Piacentini, Mauro ^c,d   Gliozzi, Alessandra ^e,f   Relini, Annalisa ^e,f   Mazzanti, Michele ^a   Jodice, Carla ^c,f  

^a UNIVERSITY OF MILAN   (Italy)

^b ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^e UNIVERSITY OF GENOA   (Italy)

^f Inter University Research Centre on the Molecular Basis of Neurodegenerative Diseases (CIMN)   (Italy)

^g ISTITUTO AUXOLOGICO ITALIANO   (Italy)

Author keywords

Ataxin 1; Membrane; Neurodegeneration; Polyglutamine disease; Spinocerebellar ataxia type 1; Unregulated ionic pathway

Indexed keywords

ATAXIN 1; HISTIDINE; POLYGLUTAMINE;

ARTICLE; ATOMIC FORCE MICROSCOPY; CELL AGGREGATION; CELL DEATH; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; ELECTRON MICROSCOPY; GENETIC TRANSFECTION; LIPID MEMBRANE; NERVE CELL DEGENERATION; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION;

ANIMALS; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; COS CELLS; HISTIDINE; LIPID BILAYERS; MICROSCOPY, ATOMIC FORCE; NERVE TISSUE PROTEINS; NUCLEAR ENVELOPE; NUCLEAR PROTEINS; PEPTIDES; SPINOCEREBELLAR ATAXIAS;

EID: 84858963708     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2012.01.016     Document Type: Article

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