Development and application of a cellular, gain-of-signal, bioluminescent reporter screen for inhibitors of type II secretion in pseudomonas aeruginosa and burkholderia pseudomallei

Journal of Biomolecular Screening

Volumn 16, Issue 7, 2011, Pages 694-705

  Moir, Donald T ^a   Di, Ming ^a   Wong, Erica ^b   Moore, Richard A ^b   Schweizer, Herbert P ^c   Woods, Donald E ^b   Bowlin, Terry L ^a  

^a MICROBIOTIX INC   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

^c Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

high throughput screening; inhibitors; Pseudomonas aeruginosa; type II secretion

Indexed keywords

BETA LACTAMASE; ELASTASE; ISOPROPYL THIOGALACTOSIDE; PHOSPHOLIPASE C; PROTEINASE; SECRETIN;

ARTICLE; BACTERIAL SECRETION SYSTEM; BACTERIAL STRAIN; BIOLUMINESCENCE; BURKHOLDERIA PSEUDOMALLEI; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; EXTRACELLULAR SPACE; IC 50; NONHUMAN; OPERON; OUTER MEMBRANE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN TRANSPORT; PSEUDOMONAS AERUGINOSA; REPORTER GENE; UPREGULATION;

ADENOSINE TRIPHOSPHATASES; BACTERIAL PROTEINS; BURKHOLDERIA PSEUDOMALLEI; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, REPORTER; HIGH-THROUGHPUT SCREENING ASSAYS; LUMINESCENT PROTEINS; MEMBRANE TRANSPORT PROTEINS; PSEUDOMONAS AERUGINOSA; SECRETORY PATHWAY; SMALL MOLECULE LIBRARIES; SODIUM AZIDE;

BURKHOLDERIA PSEUDOMALLEI; NEGIBACTERIA; PSEUDOMONAS AERUGINOSA;

EID: 79960909854     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057111408605     Document Type: Article

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