Development of a high-throughput screening assay for the discovery of small-molecule SecA inhibitors

Analytical Biochemistry

Volumn 413, Issue 2, 2011, Pages 90-96

  Segers, Kenneth ^a   Klaassen, Hugo ^b   Economou, Anastasios ^c   Chaltin, Patrick ^b,d   Anné, Jozef ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b Centre for Innovation and Stimulation of Medicines Development   (Belgium)

^c INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY   (Greece)

^d UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Antibiotics; ATPase; Bacterial protein secretion; High throughput screening; Inhibitor; SecA

Indexed keywords

ANTIBIOTICS; CHEMOTHERAPY; ESCHERICHIA COLI; PROTEINS;

ATPASE; BACTERIAL PROTEIN; HIGH THROUGHPUT SCREENING; INHIBITOR; SECA;

BIOSYNTHESIS;

ADENOSINE TRIPHOSPHATASE; BOVINE SERUM ALBUMIN; DEOXYRIBONUCLEASE; MUTANT PROTEIN; PROTEIN INHIBITOR; PROTEIN PRECURSOR; PROTEIN SECA;

ARTICLE; BACTERIAL MEMBRANE; BACTERIAL TRANSLOCATION; CYTOPLASM; ENZYME MECHANISM; HIGH THROUGHPUT SCREENING; HYDROLYSIS; PRIORITY JOURNAL; PROTEOLIPOSOME;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 79955470189     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2011.02.012     Document Type: Article

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