Neuroprotective effect of cyclooxygenase inhibitors in ICV-STZ induced sporadic alzheimer's disease in rats

Journal of Molecular Neuroscience

Volumn 46, Issue 1, 2012, Pages 223-235

  Dhull, Dinesh Kumar ^a   Jindal, Ankur ^a   Dhull, Rakesh K ^b   Aggarwal, Saurabh ^c   Bhateja, Deepak ^a   Padi, Satyanarayana S V ^a  

^a ISF COLLEGE OF PHARMACY   (India)

^b Kate Gleason College of Engineering   (United States)

^c GURU JAMBHESHWAR UNIVERSITY OF SCIENCE AND TECHNOLOGY   (India)

Author keywords

Cyclooxygenase; ICV STZ; Neuroinflammation; Oxidative stress; Sporadic Alzheimer's

Indexed keywords

ACETYLCHOLINESTERASE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 3; ETORICOXIB; GLUTATHIONE; LACTATE DEHYDROGENASE; MALONALDEHYDE; NITRITE; PHENACETIN; PROSTAGLANDIN SYNTHASE INHIBITOR; STREPTOZOCIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; VALERYL SALICYLATE; BIOLOGICAL MARKER; CYCLOOXYGENASE 2 INHIBITOR; CYCLOOXYGENASE 3 INHIBITOR; OXYGENASE INHIBITOR; SALICYLIC ACID DERIVATIVE; VALERYLSALICYLIC ACID;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME ACTIVITY; LIPID PEROXIDATION; LONG TERM CARE; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PYRAMIDAL NERVE CELL; RAT; TREATMENT DURATION; ANIMAL CELL; COGNITION; DRUG EFFICACY; IC 50; INJECTION; TREATMENT FAILURE; TREATMENT OUTCOME;

RATTUS;

ALZHEIMER DISEASE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CYCLOOXYGENASE 2 INHIBITORS; DISEASE MODELS, ANIMAL; INJECTIONS, INTRAVENTRICULAR; LIPID PEROXIDATION; MALE; NEUROPROTECTIVE AGENTS; PYRIDINES; RATS; RATS, WISTAR; SALICYLATES; STREPTOZOCIN; SULFONES;

EID: 84858842369     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9583-6     Document Type: Article

References (69)

1. Agrawal R, Tyagi E, Shukla R, Nath CA (2009) Study of brain insulin receptors, AChE activity and oxidative stress in rat model of ICV STZ induced dementia. Neuropharmacology 56:779-787
2. Aisen PS, Schafer KA, Grundman M et al (2003) Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression - a randomized controlled trial. J Am Med Assoc 289:2819-2826 (Pubitemid 37430117)
3. Bezzi P, Carmignoto G, Pasti L et al (1998) Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature 391:281-285 (Pubitemid 28099014)
4. Bruce-Keller AJ, Li YJ, Lovell MA et al (1998) 4-Hydroxynonenal, a product of lipid peroxidation, damages cholinergic neurons and impairs visuospatial memory in rats. J Neuropathol Exp Neurol 57:257-267 (Pubitemid 28125506)
5. Candelario-Jalil E, Alvarez D, Merino N, Leon OS (2003) Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils. Neurosci Res 47:245-253 (Pubitemid 37152462)
6. Chandrasekharan NV, Dai H, Roos KLT et al (2002) COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A 99:13926-13931 (Pubitemid 35215482)
7. Consilvio C, Vincent AM, Feldman EL (2004) Neuroinflammation, COX-2, and ALS-a dual role? Exp Neurol 187:1-10
8. Cui JG, Kuroda H, Chandrasekharan NV et al (2004) Cyclooxygenase-3 gene expression in Alzheimer hippocampus and in stressed human neural cells. Neurochem Res 29:1731-1737 (Pubitemid 39070064)
9. Doré S, Otsuka T, Mito T et al (2003) Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction. Ann Neurol 54:155-162 (Pubitemid 36909614)
10. Duckworth EA, Koutouzis TK, Borlongan CV et al (1999) Rats receiving systemic 3-nitropropionic acid demonstrate impairment of memory in Morris water maze. Psychobiology 27:561-566 (Pubitemid 30075657)
11. Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70-77
12. Ellman GL, Courtney KD, Andres V Jr, Feather-Stone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88-95
13. Engelhardt JI, Tajti J, Appel SH (1993) Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis. Arch Neurol 50:30-36 (Pubitemid 23019197)
14. Fass U, Panickar K, Personett D et al (2000) Differential vulnerability of primary cultured cholinergic neurons to nitric oxide excess. NeuroReport 11:931-936 (Pubitemid 30235431)
15. Gierse JK, Zhang Y, Hood WF et al (2005) Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. J Pharmacol Exp Ther 312:1206-1212 (Pubitemid 40293782)
16. Goodwin DC, Landino LM, Marnett LJ (1999) Reactions of prostaglandin endoperoxide synthase with nitric oxide and peroxynitrite. Drug Metab Rev 31:273-294 (Pubitemid 29106662)
17. 15N] nitrate in biological fluids. Ann Biochem 126:131-138
18. Hein AM, O'Banion MK (2009) Neuroinflammation and memory: the role of prostaglandins. Mol Neurobiol 40:15-32
19. Hein AM, Stutzman DL, Bland ST et al (2007) Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus. Neuroscience 150:754-763 (Pubitemid 350235798)
20. Hewett SJ, Uliasz TF, Vidwans AS, Hewett JA (2000) Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture. J Pharmacol Exp Ther 293:417-425 (Pubitemid 30244090)
21. Hoyer S (1995) Age-related changes in cerebral oxidative metabolism. Implications for drug therapy. Drugs Aging 6:210-218
22. Hoyer S, Lannert H (2007) Long-term abnormalities in brain glucose/energy metabolism after inhibition of the neuronal insulin receptor: implication of tau-protein. J Neural Transm Suppl 72:195-202
23. Ishida T, Sato T, Irifune M, Tanaka KI, Nakamura N, Nishikawa T (2007) Effect of acetaminophen, a cyclooxygenase inhibitor, on Morris water maze task performance in mice. J Psychopharmacol 21:757-767 (Pubitemid 47437916)
24. Jain NK, Patil CS, Kulkarni SK, Singh A (2002) Modulatory role of cyclooxygenase inhibitors in aging- and scopolamine or lipopolysaccharide- induced cognitive dysfunction in mice. Behav Brain Res 133:369-376 (Pubitemid 34754412)
25. Kelsen J, Kjaer K, Chen G et al (2006) Parecoxib is neuroprotective in spontaneously hypertensive rats after transient middle cerebral artery occlusion: a divided treatment response? J Neuroinflammation 3:31
26. Kukreja RC, Kontos HA, Hess ML, Ellis EF (1986) PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH. Circ Res 59:612-619 (Pubitemid 17035305)
27. Kumar A, Seghal N, Padi SV, Naidu PS (2006a) Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats. Eur J Pharmacol 551:58-66 (Pubitemid 44648058)
28. Kumar P, Padi SSV, Naidu PS, Kumar A (2006b) Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms. Behav Pharmacol 17:485-492 (Pubitemid 44325810)
29. Lipton SA (1999) Neuronal protection and destruction by NO. Cell Death Differ 6:943-951
30. Liu XJ, Lee TL, Wong PTH (2006) Cyclooxygenase-1 inhibition shortens the duration of diazepam-induced loss of righting reflex in mice. Anesth Analg 102:135-140 (Pubitemid 43038296)
31. Madrigal JLM, Moro MA, Lizasoain I et al (2003) Induction of cyclooxygenase-2 accounts for restraint stress-induced oxidative status in rat brain. Neuropsychopharmacology 28:1579-1588 (Pubitemid 41070858)
32. Markesbery WR (1999) The role of oxidative stress in Alzheimer disease. Arch Neurol 56:1449-1452
33. Matsumoto Y, Yamaguchi T, Watanabe S, Yamamoto T (2004) Involvement of arachidonic acid cascade in working memory impairment induced by interleukin-1 beta. Neuropharmacology 46:1195-1200 (Pubitemid 38529943)
34. McGeer EG, McGeer PL (2003) Inflammatory processes in Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry 27:741-749 (Pubitemid 36966754)
35. Miettinen S, Fusco FR, Yrjanheikki J et al (1997) Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A(2). Proc Natl Acad Sci U S A 94:6500-6505 (Pubitemid 27270714)
36. Misra HP, Fridovich I (1972) The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:3170-3175
37. Montine TJ, Milatovic D, Gupta RC, Valyi-Nagy T, Morrow JD, Breyer RM (2002) Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent. J Neurochem 83:463-470 (Pubitemid 35191411)
38. Moskowitz N, Schook W, Puszkin S (1984) Regulation of endogenous calcium-dependent synaptic membrane phospholipase A2. Brain Res 290:273-280
39. Muller D, Nitsch RM, Wurtman RJ, Hoyer S (1998) Streptozotocin increases free fatty acids and decreases phospholipids in rat brain. J Neural Transm 105:1271-1281 (Pubitemid 29017408)
40. Nogawa S, Zhang FY, Ross ME, Iadecola C (1997) Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci 17:2746-2755 (Pubitemid 27155008)
41. O'Banion MK (1999) COX-2 and Alzheimer's disease: potential roles in inflammation and neurodegeneration. Expert Opin Investig Drugs 8:1521-1536
42. Pasinetti GM, Aisen PS (1998) Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. Neuroscience 87:319-324 (Pubitemid 28370892)
43. Pepicelli O, Fedele E, Bonanno G et al (2002) In vivo activation of N-methyl-D-aspartate receptors in the rat hippocampus increases prostaglandin E-2 extracellular levels and triggers lipid peroxidation through cyclooxygenase-mediated mechanisms. J Neurochem 81:1028-1034 (Pubitemid 34809285)
44. Phillis JW, O'Regan MH (2003) The role of phospholipases, cyclooxygenases, and lipoxygenases in cerebral ischemic/traumatic injuries. Crit Rev Neurobiol 15:61-90 (Pubitemid 37101546)
45. Prasad MR, Lovell MA, Yatin M, Dhillon H, Markesbery WR (1998) Regional membrane phospholipid alterations in Alzheimer's disease. Neurochem Res 23:81-88 (Pubitemid 28145695)
46. Rojo LE, Fernandez JA,MaccioniAA, Jimenez JM, Maccioni RB (2008) Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease. Arch Med Res 39:1-16 (Pubitemid 350192021)
47. Salkovic-Petrisic M, Hoyer S (2007) Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach. J Neural Transm 72:217-233
48. Salzberg-Brenhouse HC, Chen EY, Emerich DF et al (2003) Inhibitors of cyclooxygenase-2, but not cyclooxygenase-1 provide structural and functional protection against quinolinic acid-induced neurodegeneration. J Pharmacol Exp Ther 306:218-228 (Pubitemid 36734376)
49. Scali C, Giovannini MG, Prosperi C, Bellucci A, Pepeu G, Casamenti F (2003) The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo. Neuroscience 117:909-919 (Pubitemid 36332308)
50. Schwab JM, Beschorner R, Meyermann R, Gozalan F, Schluesener HJ (2002) Persistent accumulation of cyclooxygenase-1-expressing microglial cells and macrophages and transient upregulation by endothelium in human brain injury. J Neurosurg 96:892-899 (Pubitemid 34415404)
51. Sharma M, Gupta YK (2002) Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats. Life Sci 71:2489-2498 (Pubitemid 35251893)
52. Sharma AC, Kulkarni SK (1991) Evaluation of learning and memory mechanisms employing elevated plus-maze in rats and mice. Prog Neuropsychopharmacol Biol Psychiatry 16:117-125
53. Sheridan AM, Sapirstein A, Lemieux N, Martin BD, Kim DK, Bonventre JV (2001) Nuclear translocation of cytosolic phospholipase A(2) is induced by ATP depletion. J Biol Chem 276:29899-29905
54. Shoham S, Bejar C, Kovalev E, Schorer-Apelbaum D, Weinstock M (2007) Ladostigil prevents gliosis, oxidative-nitrative stress and memory deficits induced by intracerebroventricular injection of streptozotocin in rats. Neuropharmacology 52:836-843 (Pubitemid 46237641)
55. Silakova JM, Hewett JA, Hewett SJ (2004) Naproxen reduces excitotoxic neurodegeneration in vivo with an extended therapeutic window. J Pharmacol Exp Ther 309:1060-1066 (Pubitemid 38669692)
56. Singh A, Naidu PS, Kulkarni SK (2003) Reversal of aging and chronic ethanol-induced cognitive dysfunction by quercetin a bioflavonoid. Free Radic Res 37:1245-1252 (Pubitemid 37322203)
57. Smith WL, DeWitt DL, Garavito RM (2000) Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 69:145-182
58. Song MS, Rauw G, Baker GB, Kar S (2008) Memantine protects rat cortical cultured neurons against beta-amyloid-induced toxicity by attenuating tau phosphorylation. Eur J Neurosci 28:1989-2002
59. Sonkusare S, Srinivasan K, Kaul C, Ramarao P (2005) Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats. Life Sci 77:1-14 (Pubitemid 40546372)
60. Sun FF, Fleming WE, Taylor BM (1993) Degradation of membrane phospholipids in the cultured human astroglial cell line UC-11MG during ATP depletion. Biochem Pharmacol 45:1149-1155 (Pubitemid 23079994)
61. Tahirovic I, Sofic E, Sapcanin A et al (2007) Reduced brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer's disease and diabetes mellitus. Neurochem Res 32:1709-1717 (Pubitemid 47428865)
62. Terwel D, Prickaerts J, Meng FP, Jolles J (1995) Brain enzyme activities after intracerebroventricular injection of streptozotocin in rats receiving acetyl-L-carnitine. Eur J Pharmacol 287:65-71
63. Tiwari V, Kuhad A, Bishnoi M, Chopra K (2009) Chronic treatment with tocotrienol, an isoform of vitamin E, prevents intracerebroventricular streptozotocin-induced cognitive impairment and oxidative-nitrosative stress in rats. Pharmacol Biochem Behav 93:183-189
64. Tuppo EE, Arias HR (2005) The role of inflammation in Alzheimer's disease. Int J Biochem Cell Biol 37:289-305 (Pubitemid 39330191)
65. Wang XL, Su B, Zheng L, Perry G, Smith MA, Zhu XW (2009) The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J Neurochem 109:153-159
66. Wills ED (1966) Mechanism of lipid peroxide formation in animal. Biochems J 99:667-676
67. Xiang Z, Thomas S, Pasinetti G (2007) Increased neuronal injury in transgenic mice with neuronal overexpression of human cyclooxygenase-2 is reversed by hypothermia and rofecoxib treatment. Curr Neurovasc Res 4:274-279 (Pubitemid 350171828)
68. Yang HW, Chen C (2008) Cyclooxygenase-2 in synaptic signaling. Curr Pharm Des 14:1443-1451
69. Zhao Z, Ksiezak-Reding H, Riggio S, Haroutunian V, Pasinetti GM (2006) Insulin receptor deficits in schizophrenia and in cellular and animal models of insulin receptor dysfunction. Schizophr Res 84:1-14