Immunoassay for human serum hemojuvelin

Haematologica

Volumn 95, Issue 12, 2010, Pages 2031-2037

  Brasse Lagnel, Carole ^a,c   Poli, Maura ^b   Lesueur, Céline ^a   Grandchamp, Bernard ^c   Lavoinne, Alain ^a   Beaumont, Carole ^c   Bekri, Soumeya ^a  

^a ROUEN UNIVERSITY HOSPITAL   (France)

^b UNIVERSITY OF BRESCIA   (Italy)

^c CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

Author keywords

Anemia; ELISA; Iron metabolism; rhRGM c; Serum; Soluble hemojuvelin

Indexed keywords

C PEPTIDE; HEMOJUVELIN; MATRIPTASE; MATRIPTASE 2; POLYCLONAL ANTIBODY; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANEMIA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; IRON DEFICIENCY ANEMIA; MALE; PROTEIN BLOOD LEVEL; VALIDATION PROCESS;

ADOLESCENT; ADULT; ANEMIA; ANEMIA, IRON-DEFICIENCY; BLOTTING, WESTERN; CHILD; CHILD, PRESCHOOL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GPI-LINKED PROTEINS; HUMANS; IRON; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MUTATION; REPRODUCIBILITY OF RESULTS; SERINE ENDOPEPTIDASES;

EID: 78649898652     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2010.022129     Document Type: Article

References (23)

1. Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dube MP, et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 2004;36(1): 77-82.
2. Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006;38(5):531-9.
3. Casanovas G, Mleczko-Sanecka K, Altamura S, Hentze MW, Muckenthaler MU. Bone morphogenetic protein (BMP)- responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD. J Mol Med. 2009;87(5):471-80.
4. Lin L, Goldberg YP, Ganz T. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood. 2005;106(8):2884-9.
5. Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest. 2007;117(7):1933-9.
6. Kuninger D, Kuns-Hashimoto R, Kuzmickas R, Rotwein P. Complex biosynthesis of the muscle-enriched iron regulator RGMc. J Cell Sci. 2006;119(Pt 16):3273-83.
7. Kuninger D, Kuns-Hashimoto R, Nili M, Rotwein P. Pro-protein convertases control the maturation and processing of the ironregulatory protein, RGMc/hemojuvelin. BMC Biochem. 2008;9:9.
8. Silvestri L, Pagani A, Camaschella C. Furinmediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis. Blood. 2008;111(2):924-31.
9. Lin L, Nemeth E, Goodnough JB, Thapa DR, Gabayan V, Ganz T. Soluble hemojuvelin is released by proprotein convertasemediated cleavage at a conserved polybasic RNRR site. Blood Cells Mol Dis. 2008; 40(1):122-31.
10. Silvestri L, Pagani A, Nai A, De Domenico I, Kaplan J, Camaschella C. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab. 2008;8(6):502-11.
11. Du X, She E, Gelbart T, Truksa J, Lee P, Xia Y, et al. The serine protease TMPRSS6 is required to sense iron deficiency. Science. 2008;320(5879):1088-92.
12. Finberg KE, Heeney MM, Campagna DR, Aydinok Y, Pearson HA, Hartman KR, et al. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet. 2008;40(5):569-71.
13. Guillem F, Lawson S, Kannengiesser C, Westerman M, Beaumont C, Grandchamp B. Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency. Blood. 2008;112(5):2089-91.
14. Melis MA, Cau M, Congiu R, Sole G, Barella S, Cao A, et al. A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. Haematologica. 2008;93(10):1473-9.
15. Silvestri L, Pagani A, Fazi C, Gerardi G, Levi S, Arosio P, et al. Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosis. Blood. 2007;109 (10):4503-10.
16. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. Immunoassay for human serum hepcidin. Blood. 2008;112(10):4292-7.
17. Maxson JE, Enns CA, Zhang AS. Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells. Blood. 2009;113(8):1786-93.
18. Lanzara C, Roetto A, Daraio F, Rivard S, Ficarella R, Simard H, et al. Spectrum of hemojuvelin gene mutations in 1q-linked juvenile hemochromatosis. Blood. 2004;103(11):4317-21.
19. Crowther JR. The ELISA guidebook. Methods Mol Biol. 2000;149:III-IV, 1-413.
20. Niederkofler V, Salie R, Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest. 2005;115 (8):2180-6.
21. Krijt J, Vokurka M, Chang KT, Necas E. Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin. Blood. 2004;104(13):4308-10.
22. Constante M, Wang D, Raymond VA, Bilodeau M, Santos MM. Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha. Am J Pathol. 2007;170(2):497-504.
23. Zhang AS, Anderson SA, Meyers KR, Hernandez C, Eisenstein RS, Enns CA. Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin. J Biol Chem. 2007;282 (17):12547-56.