메뉴 건너뛰기




Volumn 40, Issue 3, 2011, Pages 344-353

Non-surgical approach to the benign nodular goiter: New opportunities by recombinant human TSH-stimulated 131I-therapy

Author keywords

Levothyroxine; Nodular goiter; Radioiodine therapy; Recombinant human thyrotropin

Indexed keywords

ANTITHYROID AGENT; GLUCOCORTICOID; IODINE 131; LEVOTHYROXINE; PLACEBO; RADIOPHARMACEUTICAL AGENT; THYROTROPIN; THYROTROPIN I 131; UNCLASSIFIED DRUG; PHARMACEUTICAL VEHICLES AND ADDITIVES; RADIOACTIVE IODINE; RECOMBINANT PROTEIN;

EID: 84858770501     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-011-9542-6     Document Type: Review
Times cited : (15)

References (90)
  • 1
    • 0033305611 scopus 로고    scopus 로고
    • Major role of genes in the etiology of simple goiter in females: A population-based twin study
    • T.H. Brix, K.O. Kyvik, L. Hegedüs, Major role of genes in the etiology of simple goiter in females: a population-based twin study. J. Clin. Endocrinol. Metab. 84, 3071-3075 (1999) (Pubitemid 30646925)
    • (1999) Journal of Clinical Endocrinology and Metabolism , vol.84 , Issue.9 , pp. 3071-3075
    • Brix, T.H.1    Kyvik, K.O.2    Hegedus, L.3
  • 2
    • 0037323540 scopus 로고    scopus 로고
    • Management of simple nodular goiter: Current status and future perspectives
    • DOI 10.1210/er.2002-0016
    • L. Hegedüs, S.J. Bonnema, F.N. Bennedbæk, Management of simple nodular goiter: current status and future perspectives. Endocr. Rev. 24, 102-132 (2003) (Pubitemid 36223282)
    • (2003) Endocrine Reviews , vol.24 , Issue.1 , pp. 102-132
    • Hegedus, L.1    Bonnema, S.J.2    Bennedbaek, F.N.3
  • 5
    • 0028889833 scopus 로고
    • Solitary thyroid nodule. Comparison between palpation and ultrasonography
    • G.H. Tan, H. Gharib, C.C. Reading, Solitary thyroid nodule. Comparison between palpation and ultrasonography. Arch. Intern. Med. 155, 2418-2423 (1995)
    • (1995) Arch. Intern. Med. , vol.155 , pp. 2418-2423
    • Tan, G.H.1    Gharib, H.2    Reading, C.C.3
  • 7
    • 6044243265 scopus 로고    scopus 로고
    • Clinical practice. The thyroid nodule
    • L. Hegedüs, Clinical practice. The thyroid nodule. N. Engl. J. Med. 351, 1764-1771 (2004)
    • (2004) N. Engl. J. Med. , vol.351 , pp. 1764-1771
    • Hegedüs, L.1
  • 8
    • 78650055204 scopus 로고    scopus 로고
    • Approach to management of the patient with primary or secondary intrathoracic goiter
    • L. Hegedus, S.J. Bonnema, Approach to management of the patient with primary or secondary intrathoracic goiter. J. Clin. Endocrinol. Metab. 95, 5155-5162 (2010)
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 5155-5162
    • Hegedus, L.1    Bonnema, S.J.2
  • 9
    • 0036283248 scopus 로고    scopus 로고
    • MR imaging of large multinodular goiters: Observer agreement on volume versus observer disagreement on dimensions of the involved trachea
    • S.J. Bonnema, P.B. Andersen, D.U. Knudsen, L. Hegedüs, MR imaging of large multinodular goiters: observer agreement on volume versus observer disagreement on dimensions of the involved trachea. AJR Am. J. Roentgenol. 179, 259-266 (2002) (Pubitemid 34694847)
    • (2002) American Journal of Roentgenology , vol.179 , Issue.1 , pp. 259-266
    • Bonnema, S.J.1    Andersen, P.B.2    Knudsen, D.U.3    Hegedus, L.4
  • 10
    • 0030047011 scopus 로고    scopus 로고
    • Upper airways obstruction in 153 consecutive patients presenting with thyroid enlargement
    • N.J. Gittoes, M.R. Miller, J. Daykin, M.C. Sheppard, J.A. Franklyn, Upper airways obstruction in 153 consecutive patients presenting with thyroid enlargement. Br. Med. J. 312, 484 (1996) (Pubitemid 26061241)
    • (1996) British Medical Journal , vol.312 , Issue.7029 , pp. 484
    • Gittoes, N.J.L.1    Miller, M.R.2    Daykin, J.3    Sheppard, M.C.4    Franklyn, J.A.5
  • 11
    • 44249122612 scopus 로고    scopus 로고
    • Pulmonary function profile in patients with benign goiters without symptoms of respiratory compromise and the early effect of thyroidectomy
    • DOI 10.4103/0022-3859.40774
    • P.V. Pradeep, P. Tiwari, A. Mishra et al., Pulmonary function profile in patients with benign goiters without symptoms of respiratory compromise and the early effect of thyroidectomy. J. Postgrad. Med. 54, 98-101 (2008) (Pubitemid 351724191)
    • (2008) Journal of Postgraduate Medicine , vol.54 , Issue.2 , pp. 98-101
    • Pradeep, P.1    Tiwari, P.2    Mishra, A.3    Agarwal, G.4    Agarwal, A.5    Verma, A.6    Mishra, S.7
  • 12
    • 2342586081 scopus 로고    scopus 로고
    • Long-term effects of radioiodine on thyroid function, size and patient satisfaction in non-toxic diffuse goitre
    • DOI 10.1530/eje.0.1500439
    • S.J. Bonnema, V.E. Nielsen, L. Hegedüs, Long-term effects of radioiodine on thyroid function, size and patient satisfaction in non-toxic diffuse goitre. Eur. J. Endocrinol. 150, 439-445 (2004) (Pubitemid 38584693)
    • (2004) European Journal of Endocrinology , vol.150 , Issue.4 , pp. 439-445
    • Bonnema, S.J.1    Nielsen, V.E.2    Hegedus, L.3
  • 13
    • 0032944892 scopus 로고    scopus 로고
    • Diagnosis and treatment of the solitary thyroid nodule. Results of a European survey
    • DOI 10.1046/j.1365-2265.1999.00663.x
    • F.N. Bennedbæk, H. Perrild, L. Hegedüs, Diagnosis and treatment of the solitary thyroid nodule. Results of a European survey. Clin. Endocrinol. (Oxf). 50, 357-363 (1999) (Pubitemid 29166716)
    • (1999) Clinical Endocrinology , vol.50 , Issue.3 , pp. 357-363
    • Bennedbaek, F.N.1    Perrild, H.2    Hegedus, L.3
  • 14
    • 17744375783 scopus 로고    scopus 로고
    • Management of the solitary thyroid nodule: Results of a North American survey
    • DOI 10.1210/jc.85.7.2493
    • F.N. Bennedbæk, L. Hegedüs, Management of the solitary thyroid nodule: results of a North American survey. J. Clin. Endocrinol. Metab. 85, 2493-2498 (2000) (Pubitemid 32269206)
    • (2000) Journal of Clinical Endocrinology and Metabolism , vol.85 , Issue.7 , pp. 2493-2498
    • Bennedbaek, F.N.1    Hegedus, L.2
  • 16
    • 0033842583 scopus 로고    scopus 로고
    • Management of the nontoxic multinodular goitre: A European questionnaire study
    • DOI 10.1046/j.1365-2265.2000.01060.x
    • S.J. Bonnema, F.N. Bennedbæk, W.M. Wiersinga, L. Hegedüs, Management of the nontoxic multinodular goitre: a European questionnaire study. Clin. Endocrinol. (Oxf). 53, 5-12 (2000) (Pubitemid 30646121)
    • (2000) Clinical Endocrinology , vol.53 , Issue.1 , pp. 5-12
    • Bonnema, S.J.1    Bennedbaek, F.N.2    Wiersinga, W.M.3    Hegedus, L.4
  • 18
    • 0141518215 scopus 로고    scopus 로고
    • Differences between endocrine surgeons and endocrinologists in the management of non-toxic multinodular goitre
    • DOI 10.1002/bjs.4171
    • M.C. Bhagat, S.S. Dhaliwal, S.J. Bonnema, L. Hegedüs, J.P. Walsh, Differences between endocrine surgeons and endocrinologists in the management of non-toxic multinodular goitre. Br. J. Surg. 90, 1103-1112 (2003) (Pubitemid 37152169)
    • (2003) British Journal of Surgery , vol.90 , Issue.9 , pp. 1103-1112
    • Bhagat, M.C.1    Dhaliwal, S.S.2    Bonnema, S.J.3    Hegedus, L.4    Walsh, J.P.5
  • 19
    • 12244269716 scopus 로고    scopus 로고
    • Management of the nontoxic multinodular goiter in Latin America: Comparison with North America and Europe, an electronic survey
    • DOI 10.1210/jc.2004-1722
    • L.A. Diehl, V. Garcia, S.J. Bonnema, L. Hegedüs, C.C. Albino, H. Graf, Management of the nontoxic multinodular goiter in Latin America: comparison with North America and Europe, an electronic survey. J. Clin. Endocrinol. Metab. 90, 117-123 (2005) (Pubitemid 40116643)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.1 , pp. 117-123
    • Diehl, L.A.1    Garcia, V.2    Bonnema, S.J.3    Hegedus, L.4    Albino, C.C.5    Graf, H.6
  • 20
    • 0030933501 scopus 로고    scopus 로고
    • Percutaneous ethanol injection therapy in the treatment of thyroid and parathyroid diseases
    • F.N. Bennedbæk, S. Karstrup, L. Hegedüs, Percutaneous ethanol injection therapy in the treatment of thyroid and parathyroid diseases. Eur. J. Endocrinol. 136, 240-250 (1997) (Pubitemid 27130044)
    • (1997) European Journal of Endocrinology , vol.136 , Issue.3 , pp. 240-250
    • Bennedbaek, F.N.1    Karstrup, S.2    Hegedus, L.3
  • 21
    • 79959402036 scopus 로고    scopus 로고
    • Long-term outcome following interstitial laser photocoagulation of benign cold thyroid nodules
    • H. Dossing, F.N. Bennedbaek, L. Hegedus, Long-term outcome following interstitial laser photocoagulation of benign cold thyroid nodules. Eur. J. Endocrinol. 165, 123-128 (2011)
    • (2011) Eur. J. Endocrinol. , vol.165 , pp. 123-128
    • Dossing, H.1    Bennedbaek, F.N.2    Hegedus, L.3
  • 22
    • 77954205447 scopus 로고    scopus 로고
    • American association of clinical endocrinologists, Associazione Medici Endocrinologi, and european thyroid association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: Executive summary of recommendations
    • H. Gharib, E. Papini, R. Paschke et al., American association of clinical endocrinologists, Associazione Medici Endocrinologi, and european thyroid association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations. J. Endocrinol. Invest. 33, 287-291 (2010)
    • (2010) J. Endocrinol. Invest. , vol.33 , pp. 287-291
    • Gharib, H.1    Papini, E.2    Paschke, R.3
  • 24
    • 0031733240 scopus 로고    scopus 로고
    • Effect of percutaneous ethanol injection therapy versus suppressive doses of L-thyroxine on benign solitary solid cold thyroid nodules: A randomized trial
    • DOI 10.1210/jc.83.3.830
    • F.N. Bennedbæk, L.K. Nielsen, L. Hegedüs, Effect of percutaneous ethanol injection therapy versus suppressive doses of L-thyroxine on benign solitary solid cold thyroid nodules: a randomized trial. J. Clin. Endocrinol. Metab. 83, 830-835 (1998) (Pubitemid 28496454)
    • (1998) Journal of Clinical Endocrinology and Metabolism , vol.83 , Issue.3 , pp. 830-835
    • Bennedbaek, F.N.1    Nielsen, L.K.2    Hegedus, L.3
  • 25
    • 0031733918 scopus 로고    scopus 로고
    • Suppressive therapy with levothyroxine for solitary thyroid nodules: A double-blind controlled clinical study and cumulative meta-analyses
    • F. Zelmanovitz, S. Genro, J.L. Gross, Suppressive therapy with levothyroxine for solitary thyroid nodules: a double-blind controlled clinical study and cumulative meta-analyses. J. Clin. Endocrinol. Metab. 83, 3881-3885 (1998) (Pubitemid 28513566)
    • (1998) Journal of Clinical Endocrinology and Metabolism , vol.83 , Issue.11 , pp. 3881-3885
    • Zelmanovitz, F.1    Genro, S.2    Gross, J.L.3
  • 26
    • 80052546751 scopus 로고    scopus 로고
    • Reduction of thyroid nodule volume by levothyroxine and iodine alone and in combination: A randomized, placebo-controlled trial
    • doi:10.1210/jc.2011-0356
    • Grussendorf M, Reiners C, Paschke R, Wegscheider K: Reduction of thyroid nodule volume by levothyroxine and iodine alone and in combination: a randomized, placebo-controlled trial. J Clin Endocrinol Metab doi:10.1210/jc.2011-0356 (2011)
    • (2011) J Clin Endocrinol Metab
    • Grussendorf, M.1    Reiners, C.2    Paschke, R.3    Wegscheider, K.4
  • 28
    • 0017714631 scopus 로고
    • The toxic effects of small iodine supplements in patients with autonomous thyroid nodules
    • D.P. Livadas, D.A. Koutras, A. Souvatzoglou, C. Beckers, The toxic effect of small iodine supplements in patients with autonomous thyroid nodules. Clin. Endocrinol. (Oxf). 7, 121-127 (1977) (Pubitemid 8150570)
    • (1977) Clinical Endocrinology , vol.7 , Issue.2 , pp. 121-127
    • Livadas, D.P.1    Koutras, D.A.2    Souvatzoglou, A.3    Beckers, C.4
  • 29
    • 0025335441 scopus 로고
    • Comparison of placebo with L-thyroxine alone or with carbimazole for treatment of sporadic non-toxic goitre
    • DOI 10.1016/0140-6736(90)91730-X
    • A. Berghout, W.M. Wiersinga, H.A. Drexhage, N.J. Smits, J.L. Touber, Comparison of placebo with L-thyroxine alone or with carbimazole for treatment of sporadic non-toxic goitre. Lancet 336, 193-197 (1990) (Pubitemid 20229056)
    • (1990) Lancet , vol.336 , Issue.8709 , pp. 193-197
    • Berghout, A.1    Wiersinga, W.M.2    Drexhage, H.A.3    Smits, N.J.4    Touber, J.L.5
  • 31
    • 65549130576 scopus 로고    scopus 로고
    • An analysis of the natural course of subclinical hyperthyroidism
    • J.J. Diez, P. Iglesias, An analysis of the natural course of subclinical hyperthyroidism. Am. J. Med. Sci. 337, 225-232 (2009)
    • (2009) Am. J. Med. Sci. , vol.337 , pp. 225-232
    • Diez, J.J.1    Iglesias, P.2
  • 32
    • 51649087360 scopus 로고    scopus 로고
    • The majority of Danish nontoxic goitre patients are ineligible for Levothyroxine suppressive therapy
    • S. Fast, S.J. Bonnema, L. Hegedus, The majority of Danish nontoxic goitre patients are ineligible for Levothyroxine suppressive therapy. Clin. Endocrinol. (Oxf). 69, 653-658 (2008)
    • (2008) Clin. Endocrinol. (Oxf) , vol.69 , pp. 653-658
    • Fast, S.1    Bonnema, S.J.2    Hegedus, L.3
  • 33
    • 79958846735 scopus 로고    scopus 로고
    • Hyperthyroidism and other causes of thyrotoxicosis: Management guidelines of the American thyroid association and American association of clinical endocrinologists
    • R.S. Bahn, H.B. Burch, D.S. Cooper et al., Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American thyroid association and American association of clinical endocrinologists. Thyroid 21, 593-646 (2011)
    • (2011) Thyroid , vol.21 , pp. 593-646
    • Bahn, R.S.1    Burch, H.B.2    Cooper, D.S.3
  • 34
    • 33947533138 scopus 로고    scopus 로고
    • Effects of antithyroid drugs on radioiodine treatment: Systematic review and meta-analysis of randomised controlled trials
    • M.A. Walter, M. Briel, M. Christ-Crain et al., Effects of antithyroid drugs on radioiodine treatment: systematic review and meta-analysis of randomised controlled trials. Br. Med. J. 334, 514 (2007)
    • (2007) Br. Med. J. , vol.334 , pp. 514
    • Walter, M.A.1    Briel, M.2    Christ-Crain, M.3
  • 35
    • 0346724716 scopus 로고    scopus 로고
    • 131I therapy of hyperthyroid diseases: Effect on thyroid function and volume evaluated by a randomized clinical trial
    • DOI 10.1530/eje.0.1490485
    • S.J. Bonnema, F.N. Bennedbæk, J. Gram, A. Veje, J. Marving, L. Hegedüs, Resumption of methimazole after 131I therapy of hyperthyroid diseases: effect on thyroid function and volume evaluated by a randomized clinical trial. Eur. J. Endocrinol. 149, 485-492 (2003) (Pubitemid 38063062)
    • (2003) European Journal of Endocrinology , vol.149 , Issue.6 , pp. 485-492
    • Bonnema, S.J.1    Bennedbaek, F.N.2    Gram, J.3    Veje, A.4    Marving, J.5    Hegedus, L.6
  • 37
    • 0033051939 scopus 로고    scopus 로고
    • Is routine thyroxine treatment to hinder postoperative recurrence of nontoxic goiter justified?
    • DOI 10.1210/jc.84.2.756
    • L. Hegedüs, B. Nygaard, J.M. Hansen, Is routine thyroxine treatment to hinder postoperative recurrence of nontoxic goiter justified? J. Clin. Endocrinol. Metab. 84, 756-760 (1999) (Pubitemid 29075717)
    • (1999) Journal of Clinical Endocrinology and Metabolism , vol.84 , Issue.2 , pp. 756-760
    • Hegedus, L.1    Nygaard, B.2    Hansen, J.M.3
  • 38
    • 33646035188 scopus 로고    scopus 로고
    • Quality of life in patients with benign thyroid disorders. A review
    • T. Watt, M. Grønvold, A.K. Rasmussen et al., Quality of life in patients with benign thyroid disorders. A review. Eur. J. Endocrinol. 154, 501-510 (2006)
    • (2006) Eur. J. Endocrinol. , vol.154 , pp. 501-510
    • Watt, T.1    Grønvold, M.2    Rasmussen, A.K.3
  • 42
    • 0032982335 scopus 로고    scopus 로고
    • Determinants of longterm outcome of radioiodine therapy of sporadic non- toxic goitre
    • DOI 10.1046/j.1365-2265.1999.00734.x
    • R. Le Moli, M.F. Wesche, M.M. Tiel-Van Buul, W.M. Wiersinga, Determinants of longterm outcome of radioiodine therapy of sporadic non- toxic goitre. Clin. Endocrinol. (Oxf). 50, 783-789 (1999) (Pubitemid 29284513)
    • (1999) Clinical Endocrinology , vol.50 , Issue.6 , pp. 783-789
    • Le Moli, R.1    Wesche, M.F.T.2    Tiel-Van Buul, M.M.C.3    Wiersinga, W.M.4
  • 44
    • 67649669875 scopus 로고    scopus 로고
    • Radioiodine therapy for thyroid volume reduction of large goiters
    • J. Bachmann, C. Kobe, S. Bor et al., Radioiodine therapy for thyroid volume reduction of large goitres. Nucl. Med. Commun. 30, 466-471 (2009)
    • (2009) Nucl. Med. Commun. , vol.30 , pp. 466-471
    • Bachmann, J.1    Kobe, C.2    Bor, S.3
  • 45
    • 0036229327 scopus 로고    scopus 로고
    • Does radioiodine therapy have an equal effect on substernal and cervical goiter volumes? Evaluation by magnetic resonance imaging
    • S.J. Bonnema, D.U. Knudsen, H. Bertelsen et al., Does radioiodine therapy have an equal effect on substernal and cervical goiter volumes? Evaluation by magnetic resonance imaging. Thyroid 12, 313-317 (2002) (Pubitemid 34438935)
    • (2002) Thyroid , vol.12 , Issue.4 , pp. 313-317
    • Bonnema, S.J.1    Knudsen, D.U.2    Bertelsen, H.3    Mortensen, J.4    Andersen, P.B.5    Bastholt, L.6    Hegedus, L.7
  • 46
    • 34548787455 scopus 로고    scopus 로고
    • Improvement of goiter volume reduction after 0.3 mg recombinant human thyrotropin-stimulated radioiodine therapy in patients with a very large goiter: A double-blinded, randomized trial
    • DOI 10.1210/jc.2007-0501
    • S.J. Bonnema, V.E. Nielsen, H. Boel-Jørgensen et al., Improvement of goiter volume reduction after 0.3 mg recombinant human thyrotropin-stimulated radioiodine therapy in patients with a very large goiter: a double-blinded, randomized trial. J. Clin. Endocrinol. Metab. 92, 3424-3428 (2007) (Pubitemid 47435314)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , Issue.9 , pp. 3424-3428
    • Bonnema, S.J.1    Nielsen, V.E.2    Boel-Jorgensen, H.3    Grupe, P.4    Andersen, P.B.5    Bastholt, L.6    Hegedus, L.7
  • 47
    • 33746419680 scopus 로고    scopus 로고
    • Stimulation with 0.3-mg recombinant human thyrotropin prior to iodine 131 therapy to improve the size reduction of benign nontoxic nodular goiter: A prospective randomized double-blind trial
    • DOI 10.1001/archinte.166.14.1476
    • V.E. Nielsen, S.J. Bonnema, H. Boel-Jørgensen, P. Grupe, L. Hegedüs, Stimulation with 0.3-mg recombinant human thyrotropin prior to iodine 131 therapy to improve the size reduction of benign nontoxic nodular goiter: a prospective randomized double- blind trial. Arch. Intern. Med. 166, 1476-1482 (2006) (Pubitemid 44125866)
    • (2006) Archives of Internal Medicine , vol.166 , Issue.14 , pp. 1476-1482
    • Nielsen, V.E.1    Bonnema, S.J.2    Boel-Jorgensen, H.3    Grupe, P.4    Hegedus, L.5
  • 49
    • 0035031645 scopus 로고    scopus 로고
    • Effect of various doses of recombinant human thyrotropin on the thyroid radioactive iodine uptake and serum levels of thyroid hormones and thyroglobulin in normal subjects
    • DOI 10.1210/jc.86.4.1660
    • M.S. Torres, L. Ramirez, P.H. Simkin, L.E. Braverman, C.H. Emerson, Effect of various doses of recombinant human thyrotropin on the thyroid radioactive iodine uptake and serum levels of thyroid hormones and thyroglobulin in normal subjects. J. Clin. Endocrinol. Metab. 86, 1660-1664 (2001) (Pubitemid 32374920)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.4 , pp. 1660-1664
    • Torres, M.S.T.1    Ramirez, L.2    Simkin, P.H.3    Braverman, L.E.4    Emerson, C.H.5
  • 50
    • 0033762167 scopus 로고    scopus 로고
    • Administration of a single low dose of recombinant human thyrotropin significantly enhances thyroid radioiodide uptake in nontoxic nodular goiter
    • D.A. Huysmans, W.A. Nieuwlaat, R.J. Erdtsieck et al., Administration of a single low dose of recombinant human thyrotropin significantly enhances thyroid radioiodide uptake in nontoxic nodular goiter. J. Clin. Endocrinol. Metab. 85, 3592-3596 (2000)
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 3592-3596
    • Huysmans, D.A.1    Nieuwlaat, W.A.2    Erdtsieck, R.J.3
  • 51
    • 12244283717 scopus 로고    scopus 로고
    • 131I therapy of patients with nodular goiter: An evaluation by a randomized double-blinded trial
    • DOI 10.1210/jc.2004-1550
    • V.E. Nielsen, S.J. Bonnema, H. Boel-Jørgensen, A. Veje, L. Hegedüs, Recombinant human thyrotropin markedly changes the 131I kinetics during 131I therapy of patients with nodular goiter: an evaluation by a randomized double-blinded trial. J. Clin. Endocrinol. Metab. 90, 79-83 (2005) (Pubitemid 40116637)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.1 , pp. 79-83
    • Nielsen, V.E.1    Bonnema, S.J.2    Boel-Jorgensen, H.3    Veje, A.4    Hegedus, L.5
  • 53
    • 64749087054 scopus 로고    scopus 로고
    • Evaluation of various doses of recombinant human thyrotropin in patients with multinodular goiters
    • L. Braverman, R.T. Kloos, B. Law Jr., M. Kipnes, M. Dionne, J. Magner, Evaluation of various doses of recombinant human thyrotropin in patients with multinodular goiters. Endocr. Pract. 14, 832-839 (2008)
    • (2008) Endocr. Pract. , vol.14 , pp. 832-839
    • Braverman, L.1    Kloos, R.T.2    Law Jr., B.3    Kipnes, M.4    Dionne, M.5    Magner, J.6
  • 54
    • 64549129181 scopus 로고    scopus 로고
    • Time to reconsider nonsurgical therapy of benign non-toxic multinodular goitre: Focus on recombinant human TSH augmented radioiodine therapy
    • S. Fast, V.E. Nielsen, S.J. Bonnema, L. Hegedus, Time to reconsider nonsurgical therapy of benign non-toxic multinodular goitre: focus on recombinant human TSH augmented radioiodine therapy. Eur. J. Endocrinol. 160, 517-528 (2009)
    • (2009) Eur. J. Endocrinol. , vol.160 , pp. 517-528
    • Fast, S.1    Nielsen, V.E.2    Bonnema, S.J.3    Hegedus, L.4
  • 55
    • 0035182049 scopus 로고    scopus 로고
    • Pretreatment with recombinant human TSH changes the regional distribution of radioiodine on thyroid scintigrams of nodular goiters
    • DOI 10.1210/jc.86.11.5330
    • W.A. Nieuwlaat, A.R. Hermus, F. Sivro-Prndelj, F.H. Corstens, D.A. Huysmans, Pretreatment with recombinant human TSH changes the regional distribution of radioiodine on thyroid scintigrams of nodular goiters. J. Clin. Endocrinol. Metab. 86, 5330-5336 (2001) (Pubitemid 33070255)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.11 , pp. 5330-5336
    • Nieuwlaat, W.-A.1    Hermus, A.R.2    Sivro-Prndelj, F.3    Corstens, F.H.4    Huysmans, D.A.5
  • 56
    • 66149103709 scopus 로고    scopus 로고
    • Optimizing 131I uptake after rhTSH stimulation in patients with nontoxic multinodular goiter: Evidence from a prospective, randomized, double-blind study
    • S. Fast, V.E. Nielsen, P. Grupe, S.J. Bonnema, L. Hegedus, Optimizing 131I uptake after rhTSH stimulation in patients with nontoxic multinodular goiter: evidence from a prospective, randomized, double-blind study. J. Nucl. Med. 50, 732-737 (2009)
    • (2009) J. Nucl. Med. , vol.50 , pp. 732-737
    • Fast, S.1    Nielsen, V.E.2    Grupe, P.3    Bonnema, S.J.4    Hegedus, L.5
  • 58
    • 1642448565 scopus 로고    scopus 로고
    • Utility of recombinant human thyrotropin for augmentation of radioiodine uptake and treatment of nontoxic and toxic multinodular goiters
    • D.S. Duick, H.J. Baskin, Utility of recombinant human thyrotropin for augmentation of radioiodine uptake and treatment of nontoxic and toxic multinodular goiters. Endocr. Prac. 9, 204-209 (2003)
    • (2003) Endocr. Prac. , vol.9 , pp. 204-209
    • Duick, D.S.1    Baskin, H.J.2
  • 60
    • 33644600612 scopus 로고    scopus 로고
    • Low-dose recombinant human thyrotropin-aided radioiodine treatment of large, multinodular goiters in elderly patients
    • O. Cohen, J. Ilany, C. Hoffman et al., Low-dose recombinant human thyrotropin-aided radioiodine treatment of large, multinodular goiters in elderly patients. Eur. J. Endocrinol. 154, 243-252 (2006)
    • (2006) Eur. J. Endocrinol. , vol.154 , pp. 243-252
    • Cohen, O.1    Ilany, J.2    Hoffman, C.3
  • 61
    • 34250864380 scopus 로고    scopus 로고
    • Safety and efficacy of administering 0.2 mg of recombinant human TSH for two consecutive days as an adjuvant to therapy with low radioiodine doses in elderly out-patients with large nontoxic multinodular goiter
    • M. Giusti, C. Cappi, B. Santaniello et al., Safety and efficacy of administering 0.2 mg of recombinant human TSH for two consecutive days as an adjuvant to therapy with low radioiodine doses in elderly out-patients with large nontoxic multinodular goiter. Minerva Endocrinol. 31, 191-209 (2006)
    • (2006) Minerva Endocrinol. , vol.31 , pp. 191-209
    • Giusti, M.1    Cappi, C.2    Santaniello, B.3
  • 62
    • 38349099257 scopus 로고    scopus 로고
    • Effect of 30 mCi radioiodine on multinodular goiter previously treated with recombinant human thyroid-stimulating hormone
    • G.J. Paz-Filho, C.O. Mesa-Junior, M. Olandoski et al., Effect of 30 mCi radioiodine on multinodular goiter previously treated with recombinant human thyroid-stimulating hormone. Braz. J. Med. Biol. Res. 40, 1661-1670 (2007)
    • (2007) Braz. J. Med. Biol. Res. , vol.40 , pp. 1661-1670
    • Paz-Filho, G.J.1    Mesa-Junior, C.O.2    Olandoski, M.3
  • 63
    • 62549140986 scopus 로고    scopus 로고
    • Recombinant human TSH increases the efficacy of a fixed activity of radioiodine for treatment of multinodular goiter
    • E.R. Cubas, G.J. Paz-Filho, M. Olandoski et al., Recombinant human TSH increases the efficacy of a fixed activity of radioiodine for treatment of multinodular goitre. Int. J. Clin. Pract. 63, 583-590 (2009)
    • (2009) Int. J. Clin. Pract. , vol.63 , pp. 583-590
    • Cubas, E.R.1    Paz-Filho, G.J.2    Olandoski, M.3
  • 64
    • 70349106428 scopus 로고    scopus 로고
    • High prevalence of side effects after recombinant human thyrotropin-stimulated radioiodine treatment with 30 mCi in patients with multinodular goiter and subclinical/ clinical hyperthyroidism
    • R. Romao, I.G. Rubio, E.K. Tomimori, R.Y. Camargo, M. Knobel, G. Medeiros-Neto, High prevalence of side effects after recombinant human thyrotropin-stimulated radioiodine treatment with 30 mCi in patients with multinodular goiter and subclinical/ clinical hyperthyroidism. Thyroid 19, 945-951 (2009)
    • (2009) Thyroid , vol.19 , pp. 945-951
    • Romao, R.1    Rubio, I.G.2    Tomimori, E.K.3    Camargo, R.Y.4    Knobel, M.5    Medeiros-Neto, G.6
  • 65
    • 79955727891 scopus 로고    scopus 로고
    • Long-term outcome of lowactivity radioiodine administration proceeded by adjuvant recombinant human TSH pretreatment in elderly subjects with multinodular goiter
    • Giusti M, Caputo M, Calamia I et al.: Long-term outcome of lowactivity radioiodine administration proceeded by adjuvant recombinant human TSH pretreatment in elderly subjects with multinodular goiter. Thyroid Res. 2, 6 (2009)
    • (2009) Thyroid Res. , vol.2 , pp. 6
    • Giusti, M.1    Caputo, M.2    Calamia, I.3
  • 66
    • 77950113321 scopus 로고    scopus 로고
    • Radioiodine plus recombinant human thyrotropin do not cause acute airway compression and are effective in reducing multinodular goiter
    • C.C. Albino, H. Graf, G. Paz-Filho et al., Radioiodine plus recombinant human thyrotropin do not cause acute airway compression and are effective in reducing multinodular goiter. Braz. J. Med. Biol. Res. 43, 303-309 (2010)
    • (2010) Braz. J. Med. Biol. Res. , vol.43 , pp. 303-309
    • Albino, C.C.1    Graf, H.2    Paz-Filho, G.3
  • 67
    • 77955367523 scopus 로고    scopus 로고
    • Recombinant human thyrotropin- stimulated radioiodine therapy of nodular goiter allows major reduction of the radiation burden with retained efficacy
    • S. Fast, L. Hegedus, P. Grupe et al., Recombinant human thyrotropin- stimulated radioiodine therapy of nodular goiter allows major reduction of the radiation burden with retained efficacy. J. Clin. Endocrinol. Metab. 95, 3719-3725 (2010)
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 3719-3725
    • Fast, S.1    Hegedus, L.2    Grupe, P.3
  • 68
    • 79959812003 scopus 로고    scopus 로고
    • Radioiodine (131)I treatment for large nodular goiter: Recombinant human thyrotropin allows the reduction of radioiodine (131)I activity to be administered in patients with low uptake
    • C. Ceccarelli, L. Antonangeli, F. Brozzi et al., Radioiodine (131)I treatment for large nodular goiter: recombinant human thyrotropin allows the reduction of radioiodine (131)I activity to be administered in patients with low uptake. Thyroid 21, 759-764 (2011)
    • (2011) Thyroid , vol.21 , pp. 759-764
    • Ceccarelli, C.1    Antonangeli, L.2    Brozzi, F.3
  • 69
    • 33646941325 scopus 로고    scopus 로고
    • Therapiekonzepte der euthyreoten struma nodosa: Radioiodtherapie als attraktive alternative zur operation
    • M. Dietlein, B. Dederichs, C. Kobe, P. Theissen, M. Schmidt, H. Schicha, Therapy for non-toxic multinodular goiter: radioiodine therapy as attractive alternative to surgery. Nuklearmedizin 45, 21-34 (2006) (Pubitemid 44070818)
    • (2006) NuklearMedizin , vol.45 , Issue.1 , pp. 21-34
    • Dietlein, M.1    Dederichs, B.2    Kobe, C.3    Theissen, P.4    Schmidt, M.5    Schicha, H.6
  • 70
    • 49649091329 scopus 로고    scopus 로고
    • An outline concerning the potential use of recombinant human thyrotropin for improving radioiodine therapy of multinodular goiter
    • G. Medeiros-Neto, S. Marui, M. Knobel, An outline concerning the potential use of recombinant human thyrotropin for improving radioiodine therapy of multinodular goiter. Endocrine 33, 109-117 (2008)
    • (2008) Endocrine , vol.33 , pp. 109-117
    • Medeiros-Neto, G.1    Marui, S.2    Knobel, M.3
  • 71
    • 56249146704 scopus 로고    scopus 로고
    • Recombinant human thyrotropin in the management of thyroid disorders
    • G.J. Paz-Filho, H. Graf, Recombinant human thyrotropin in the management of thyroid disorders. Expert. Opin. Biol. Ther. 8, 1721-1732 (2008)
    • (2008) Expert. Opin. Biol. Ther. , vol.8 , pp. 1721-1732
    • Paz-Filho, G.J.1    Graf, H.2
  • 72
    • 33751329055 scopus 로고    scopus 로고
    • Radioiodine therapy in non-toxic multinodular goitre. The possibility of effect-amplification with recombinant human TSH (rhTSH)
    • DOI 10.1080/02841860600617084, PII KVM507763J104616
    • S.J. Bonnema, V.E. Nielsen, L. Hegedüs, Radioiodine therapy in non-toxic multinodular goitre. The possibility of effect-amplification with recombinant human TSH (rhTSH). Acta Oncol. 45, 1051-1058 (2006) (Pubitemid 44815502)
    • (2006) Acta Oncologica , vol.45 , Issue.8 , pp. 1051-1058
    • Bonnema, S.J.1    Nielsen, V.E.2    Hegedus, L.3
  • 73
    • 10844289568 scopus 로고    scopus 로고
    • The effects of recombinant human thyrotropin, in normal subjects and patients with goitre
    • DOI 10.1111/j.1365-2265.2004.02134.x
    • V.E. Nielsen, S.J. Bonnema, L. Hegedüs, The effects of recombinant human thyrotropin, in normal subjects and patients with goitre. Clin. Endocrinol. (Oxf). 61, 655-663 (2004) (Pubitemid 40006785)
    • (2004) Clinical Endocrinology , vol.61 , Issue.6 , pp. 655-663
    • Nielsen, V.E.1    Bonnema, S.J.2    Hegedus, L.3
  • 74
    • 53749090714 scopus 로고    scopus 로고
    • Recombinant human thyrotropin-stimulated radioiodine therapy of large nodular goiters facilitates tracheal decompression and improves inspiration
    • S.J. Bonnema, V.E. Nielsen, H. Boel-Jorgensen et al., Recombinant human thyrotropin-stimulated radioiodine therapy of large nodular goiters facilitates tracheal decompression and improves inspiration. J. Clin. Endocrinol. Metab. 93, 3981-3984 (2008)
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 3981-3984
    • Bonnema, S.J.1    Nielsen, V.E.2    Boel-Jorgensen, H.3
  • 75
    • 80053129936 scopus 로고    scopus 로고
    • Serum thyroxine and age: Rather than thyroid volume and serum TSH: Are determinants of the thyroid radioiodine uptake in patients with nodular goiter
    • S.J. Bonnema, S. Fast, V.E. Nielsen et al., Serum thyroxine and age: rather than thyroid volume and serum TSH: are determinants of the thyroid radioiodine uptake in patients with nodular goiter. J. Endocrinol. Invest. 34, e52-e57 (2011)
    • (2011) J. Endocrinol. Invest. , vol.34
    • Bonnema, S.J.1    Fast, S.2    Nielsen, V.E.3
  • 78
    • 0028606198 scopus 로고
    • Acute changes in thyroid volume and function following 131I therapy of multinodular goitre
    • B. Nygaard, J. Faber, L. Hegedüs, Acute changes in thyroid volume and function following 131I therapy of multinodular goitre. Clin. Endocrinol. (Oxf). 41, 715-718 (1994)
    • (1994) Clin. Endocrinol. (Oxf) , vol.41 , pp. 715-718
    • Nygaard, B.1    Faber, J.2    Hegedüs, L.3
  • 79
    • 44249089750 scopus 로고    scopus 로고
    • Upper airway obstruction due to goiter: An overlooked problem
    • S.J. Bonnema, Upper airway obstruction due to goiter: an overlooked problem. J. Postgrad. Med. 54, 82-83 (2008)
    • (2008) J. Postgrad. Med. , vol.54 , pp. 82-83
    • Bonnema, S.J.1
  • 81
    • 0034050001 scopus 로고    scopus 로고
    • Thyroid cancer prevalence after radioiodine treatment of hyperthyroidism
    • T. Angusti, A. Codegone, R. Pellerito, A. Favero, Thyroid cancer prevalence after radioiodine treatment of hyperthyroidism. J. Nucl. Med. 41, 1006-1009 (2000) (Pubitemid 30396648)
    • (2000) Journal of Nuclear Medicine , vol.41 , Issue.6 , pp. 1006-1009
    • Angusti, T.1    Codegone, A.2    Pellerito, R.3    Favero, A.4
  • 82
    • 0033583978 scopus 로고    scopus 로고
    • Cancer incidence and mortality after radioiodine treatment for hyperthyroidism: A population-based cohort study
    • DOI 10.1016/S0140-6736(98)12295-X
    • J.A. Franklyn, P. Maisonneuve, M. Sheppard, J. Betteridge, P. Boyle, Cancer incidence and mortality after radioiodine treatment for hyperthyroidism: a population-based cohort study. Lancet 353, 2111-2115 (1999) (Pubitemid 29278480)
    • (1999) Lancet , vol.353 , Issue.9170 , pp. 2111-2115
    • Franklyn, J.A.1    Maisonneuve, P.2    Sheppard, M.3    Betteridge, J.4    Boyle, P.5
  • 84
    • 0026604105 scopus 로고
    • Cancer mortality after iodine-131 therapy for hyperthyroidism
    • P. Hall, G. Berg, G. Bjelkengren et al., Cancer mortality after iodine-131 therapy for hyperthyroidism. Int. J. Cancer 50, 886-890 (1992)
    • (1992) Int. J. Cancer , vol.50 , pp. 886-890
    • Hall, P.1    Berg, G.2    Bjelkengren, G.3
  • 85
    • 34248341689 scopus 로고    scopus 로고
    • Increased cancer incidence after radioiodine treatment for hyperthyroidism
    • DOI 10.1002/cncr.22635
    • S. Metso, A. Auvinen, H. Huhtala, J. Salmi, H. Oksala, P. Jaatinen, Increased cancer incidence after radioiodine treatment for hyperthyroidism. Cancer 109, 1972-1979 (2007) (Pubitemid 46744190)
    • (2007) Cancer , vol.109 , Issue.10 , pp. 1972-1979
    • Metso, S.1    Auvinen, A.2    Huhtala, H.3    Salmi, J.4    Oksala, H.5    Jaatinen, P.6
  • 86
    • 0032578119 scopus 로고    scopus 로고
    • Cancermortality following treatment for adult hyperthyroidism. Cooperative thyrotoxicosis therapy follow-up study group
    • E. Ron, M.M.Doody, D.V. Becker et al., Cancermortality following treatment for adult hyperthyroidism. Cooperative thyrotoxicosis therapy follow-up study group. JAMA 280, 347-355 (1998)
    • (1998) JAMA , vol.280 , pp. 347-355
    • Ron, E.1    Doody, M.M.2    Becker, D.V.3
  • 87
    • 76649134889 scopus 로고    scopus 로고
    • Dose-dependent acute effects of recombinant human TSH (rhTSH) on thyroid size and function: Comparison of 0.1, 0.3 and 0.9 mg of rhTSH
    • S. Fast, V.E. Nielsen, S.J. Bonnema, L. Hegedus, Dose-dependent acute effects of recombinant human TSH (rhTSH) on thyroid size and function: comparison of 0.1, 0.3 and 0.9 mg of rhTSH. Clin. Endocrinol. (Oxf). 72, 411-416 (2010)
    • (2010) Clin. Endocrinol. (Oxf) , vol.72 , pp. 411-416
    • Fast, S.1    Nielsen, V.E.2    Bonnema, S.J.3    Hegedus, L.4
  • 88
    • 33646042578 scopus 로고    scopus 로고
    • Transient goiter enlargement after administration of 0.3 mg of recombinant human thyrotropin in patients with benign nontoxic nodular goiter: A randomized, double-blind, crossover trial
    • V.E. Nielsen, S.J. Bonnema, L. Hegedüs, Transient goiter enlargement after administration of 0.3 mg of recombinant human thyrotropin in patients with benign nontoxic nodular goiter: a randomized, double-blind, crossover trial. J. Clin. Endocrinol. Metab. 91, 1317-1322 (2006)
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 1317-1322
    • Nielsen, V.E.1    Bonnema, S.J.2    Hegedüs, L.3
  • 89
    • 79955680562 scopus 로고    scopus 로고
    • Modified-release recombinant human TSH (MRrhTSH) augments the effect of 131I therapy in benign multinodular goiter. Results from a multicenter international, randomized, placebo-controlled study
    • H. Graf, S. Fast, F. Pacini et al., Modified-release recombinant human TSH (MRrhTSH) augments the effect of 131I therapy in benign multinodular goiter. Results from a multicenter international, randomized, placebo-controlled study. J. Clin. Endocrinol. Metab. 96, 1368-1376 (2011)
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. 1368-1376
    • Graf, H.1    Fast, S.2    Pacini, F.3
  • 90
    • 33644904600 scopus 로고    scopus 로고
    • Prolonged follow-up of multinodular goitre patients treated with radioiodine preceded or not by human recombinant TSH
    • M.S. Cardia, I.G. Rubio, G. Medeiros-Neto, Prolonged follow-up of multinodular goitre patients treated with radioiodine preceded or not by human recombinant TSH. Clin. Endocrinol. (Oxf).64, 474 (2006)
    • (2006) Clin. Endocrinol. (Oxf) , vol.64 , pp. 474
    • Cardia, M.S.1    Rubio, I.G.2    Medeiros-Neto, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.