Radioiodine plus recombinant human thyrotropin do not cause acute airway compression and are effective in reducing multinodular goiter

Brazilian Journal of Medical and Biological Research

Volumn 43, Issue 3, 2010, Pages 303-309

  Albino, C C ^a,b   Graf, H ^c   Paz Filho, G ^c,d   Diehl, L A ^e   Olandoski, M ^f   Sabbag, A ^f   Buchpiguel, C ^g  

^a Instituto de Diabetes E Endocrinologia de Maringá IDEM and Núcleo Diagnóstico   (Brazil)

^b Nucleo de Diagnosticos Maringa   (Brazil)

^c FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^d Australian National University   (Australia)

^e STATE UNIVERSITY OF LONDRINA   (Brazil)

^f PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

^g UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Hyperthyroidism; Multinodular goiter; Thyrotropin alpha; Tracheal airway

Indexed keywords

IODINE 131; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; PROPRANOLOL DERIVATIVE; RECOMBINANT THYROTROPIN; THYROID ANTIBODY; THYROID HORMONE;

ACTINIC THYROIDITIS; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; GOITER; HUMAN; HYPOTHYROIDISM; MALE; NODULAR GOITER; NUCLEAR MAGNETIC RESONANCE IMAGING; ORGAN SIZE; RADIOISOTOPE THERAPY; RANDOMIZED CONTROLLED TRIAL; THYROIDITIS; TRACHEA COMPRESSION;

EID: 77950113321     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2010007500001     Document Type: Article

References (26)

1. Hegedus L, Bonnema SJ, Bennedbaek FN. Management of simple nodular goiter: current status and future perspectives. Endocr Rev 2003; 24: 102-132.
2. Hegedus L, Hansen BM, Knudsen N, Hansen JM. Reduction of size of thyroid with radioactive iodine in multinodular non-toxic goitre. BMJ 1988; 297: 661-662.
3. Nygaard B, Hegedus L, Gervil M, Hjalgrim H, Soe-Jensen P, Hansen JM. Radioiodine treatment of multinodular non-toxic goitre. BMJ 1993; 307: 828-832.
4. Huysmans DA, Hermus AR, Corstens FH, Barentsz JO, Kloppenborg PW. Large, compressive goiters treated with radioiodine. Ann Intern Med 1994; 121: 757-762.
5. Huysmans DA, Buijs WC, van de Ven MT, van den Broek WJ, Kloppenborg PW, Hermus AR, et al. Dosimetry and risk estimates of radioiodine therapy for large, multinodular goiters. J Nucl Med 1996; 37: 2072-2079.
6. Huysmans DA, Nieuwlaat WA, Erdtsieck RJ, Schellekens AP, Bus JW, Bravenboer B, et al. Administration of a single low dose of recombinant human thyrotropin significantly enhances thyroid radioiodide uptake in nontoxic nodular goiter. J Clin Endocrinol Metab 2000; 85: 3592-3596.
7. Nieuwlaat WA, Hermus AR, Sivro-Prndelj F, Corstens FH, Huysmans DA. Pretreatment with recombinant human TSH changes the regional distribution of radioiodine on thyroid scintigrams of nodular goiters. J Clin Endocrinol Metab 2001; 86: 5330-5336.
8. Nieuwlaat WA, Huysmans DA, van den Bosch HC, Sweep CG, Ross HA, Corstens FH, et al. Pretreatment with a single, low dose of recombinant human thyrotropin allows dose reduction of radioiodine therapy in patients with nodular goiter. J Clin Endocrinol Metab 2003; 88: 3121-3129.
9. Albino CC, Mesa CO Jr, Olandoski M, Ueda CE, Woellner LC, Goedert CA, et al. Recombinant human thyrotropin as adjuvant in the treatment of multinodular goiters with radioiodine. J Clin Endocrinol Metab 2005; 90: 2775-2780.
10. Cubas ER, Paz-Filho GJ, Olandoski M, Goedert CA, Woellner LC, Carvalho GA, et al. Recombinant human TSH increases the efficacy of a fixed activity of radioiodine for treatment of multinodular goitre. Int J Clin Pract 2009; 63: 583-590.
11. Paz-Filho GJ, Mesa CO, Carvalho GA, Goedert CA, Graf H. Recombinant human TSH associated with radioiodine does not have further effects on thyroid volume and function after 2 years. Clin Endocrinol 2008; 69: 345-346.
12. Paz-Filho GJ, Mesa-Junior CO, Olandoski M, Woellner LC, Goedert CA, Boguszewski CL, et al. Effect of 30 mCi radioiodine on multinodular goiter previously treated with recombinant human thyroid-stimulating hormone. Braz J Med Biol Res 2007; 40: 1661-1670.
13. Nielsen VE, Bonnema SJ, Hegedus L. Effects of 0.9 mg recombinant human thyrotropin on thyroid size and function in normal subjects: a randomized, double-blind, cross-over trial. J Clin Endocrinol Metab 2004; 89: 2242-2247.
14. Nielsen VE, Bonnema SJ, Hegedus L. Transient goiter enlargement after administration of 0.3 mg of recombinant human thyrotropin in patients with benign nontoxic nodular goiter: a randomized, double-blind, crossover trial. J Clin Endocrinol Metab 2006; 91: 1317-1322.
15. Fast S, Nielsen VE, Bonnema SJ, Hegedus L. Dose-dependent acute effects of recombinant human TSH (rhTSH) on thyroid size and function. Comparison of 0.1, 0.3 and 0.9 mg of rhTSH. Clin Endocrinol 2009 [Epub ahead of print; doi: 10.1111/j.1365-2265.2009.03650.x].
16. Bonnema SJ, Bertelsen H, Mortensen J, Andersen PB, Knudsen DU, Bastholt L, et al. The feasibility of high dose iodine 131 treatment as an alternative to surgery in patients with a very large goiter: effect on thyroid function and size and pulmonary function. J Clin Endocrinol Metab 1999; 84: 3636-3641.
17. 131I therapy of multinodular goitre. Clin Endocrinol 1994; 41: 715-718.
18. Bonnema SJ, Nielsen VE, Boel-Jorgensen H, Grupe P, Andersen PB, Bastholt L, et al. Recombinant human thyrotropin-stimulated radioiodine therapy of large nodular goiters facilitates tracheal decompression and improves inspiration. J Clin Endocrinol Metab 2008; 93: 3981-3984.
19. Huysmans DA, de Haas MM, van den Broek WJ, Hermus AR, Barentsz JO, Corstens FH, et al. Magnetic resonance imaging for volume estimation of large multinodular goitres: a comparison with scintigraphy. Br J Radiol 1994; 67: 519-523.
20. Pocock SJ. Clinical trials. A practical approach. Brisbane: John Wiley & Sons; 1989.
21. Cohen O, Ilany J, Hoffman C, Olchovsky D, Dabhi S, Karasik A, et al. Low-dose recombinant human thyrotropin-aided radioiodine treatment of large, multinodular goiters in elderly patients. Eur J Endocrinol 2006; 154: 243-252.
22. Silva MN, Rubio IG, Romao R, Gebrin EM, Buchpiguel C, Tomimori E, et al. Administration of a single dose of recombinant human thyrotrophin enhances the efficacy of radioiodine treatment of large compressive multinodular goitres. Clin Endocrinol 2004; 60: 300-308.
23. Bonnema SJ, Nielsen VE, Boel-Jorgensen H, Grupe P, Andersen PB, Bastholt L, et al. Improvement of goiter volume reduction after 0.3 mg recombinant human thyrotropin-stimulated radioiodine therapy in patients with a very large goiter: a double-blinded, randomized trial. J Clin Endocrinol Metab 2007; 92: 3424-3428.
24. Nielsen VE, Bonnema SJ, Boel-Jorgensen H, Grupe P, Hegedus L. Stimulation with 0.3-mg recombinant human thyrotropin prior to iodine 131 therapy to improve the size reduction of benign nontoxic nodular goiter: a prospective randomized double-blind trial. Arch Intern Med 2006; 166: 1476-1482.
25. Rubio IG, Perone BH, Silva MN, Knobel M, Medeiros-Neto G. Human recombinant TSH preceding a therapeutic dose of radioiodine for multinodular goiters has no significant effect in the surge of TSH-receptor and TPO antibodies. Thyroid 2005; 15: 134-139.
26. Nielsen VE, Bonnema SJ, Hegedus L. The effects of recombinant human thyrotropin, in normal subjects and patients with goitre. Clin Endocrinol 2004; 61: 655-663.