Dose-dependent acute effects of recombinant human TSH (rhTSH) on thyroid size and function: Comparison of 0·1, 0·3 and 0·9 mg of rhTSH

Clinical Endocrinology

Volumn 72, Issue 3, 2010, Pages 411-416

  Fast, Søren ^a   Nielsen, Viveque E ^a   Bonnema, Steen J ^a   Hegedüs, Laszlo ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

LIOTHYRONINE; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; RECOMBINANT THYROTROPIN; THYROGLOBULIN; THYROTROPIN; THYROXINE;

ADULT; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFECT; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; GOITER; HEADACHE; HUMAN; HYPERTHYROIDISM; INCREASED APPETITE; MALE; MYALGIA; NAUSEA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESTLESSNESS; SIDE EFFECT; SWEATING; TACHYCARDIA; THYROID DISEASE; THYROID FUNCTION; THYROID PAIN; THYROID TENDERNESS; THYROID WEIGHT; THYROTROPIN BLOOD LEVEL; ULTRASOUND; VOLUNTEER;

ADULT; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; HUMANS; MALE; MIDDLE AGED; ORGAN SIZE; RECOMBINANT PROTEINS; THYROGLOBULIN; THYROID GLAND; THYROID HORMONES; THYROTROPIN; YOUNG ADULT;

EID: 76649134889     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2009.03650.x     Document Type: Article

References (25)

1. Nieuwlaat, W.A., Huysmans, D.A., van den Bosch, H.C. et al. (2003) Pretreatment with a single, low dose of recombinant human thyrotropin allows dose reduction of radioiodine therapy in patients with nodular goiter. Journal of Clinical Endocrinology and Metabolism, 88, 3121 3129.
2. Bonnema, S.J., Nielsen, V.E., Boel-Jorgensen, H. et al. (2007) Improvement of goiter volume reduction after 0.3 mg recombinant human thyrotropin-stimulated radioiodine therapy in patients with a very large goiter: a double-blinded, randomized trial. Journal of Clinical Endocrinology and Metabolism, 92, 3424 3428.
3. Nielsen, V.E., Bonnema, S.J., Boel-Jorgensen, H. et al. (2006) Stimulation with 0.3-mg recombinant human thyrotropin prior to iodine 131 therapy to improve the size reduction of benign nontoxic nodular goiter: a prospective randomized double-blind trial. Archives of Internal Medicine, 166, 1476 1482. (Pubitemid 44125866)
4. Silva, M.N., Rubio, I.G., Romao, R. et al. (2004) Administration of a single dose of recombinant human thyrotrophin enhances the efficacy of radioiodine treatment of large compressive multinodular goitres. Clinical Endocrinology, 60, 300 308.
5. Barca, M.F., Gruppi, C., Oliveira, M.T. et al. (2007) Cardiovascular assessment of hyperthyroid patients with multinodular goiter before and after radioiodine treatment preceded by stimulation with recombinant human TSH. Endocrine, 32, 175 181.
6. Nielsen, V.E., Bonnema, S.J. Hegedus, L. (2004) The effects of recombinant human thyrotropin, in normal subjects and patients with goitre. Clinical Endocrinology, 61, 655 663.
7. Torres, M.S., Ramirez, L., Simkin, P.H. et al. (2001) Effect of various doses of recombinant human thyrotropin on the thyroid radioactive iodine uptake and serum levels of thyroid hormones and thyroglobulin in normal subjects. Journal of Clinical Endocrinology and Metabolism, 86, 1660 1664.
8. Nielsen, V.E., Bonnema, S.J. Hegedus, L. (2004) Effects of 0.9 mg recombinant human thyrotropin on thyroid size and function in normal subjects: a randomized, double-blind, cross-over trial. Journal of Clinical Endocrinology and Metabolism, 89, 2242 2247.
9. Nielsen, V.E., Bonnema, S.J. Hegedus, L. (2006) Transient goiter enlargement after administration of 0.3 mg of recombinant human thyrotropin in patients with benign nontoxic nodular goiter: a randomized, double-blind, crossover trial. Journal of Clinical Endocrinology and Metabolism, 91, 1317 1322.
10. Braverman, L., Kloos, R.T. Law, B. Jr. (2008) Evaluation of various doses of recombinant human thyrotropin in patients with multinodular goiters. Endocrine Practice, 14, 832 839.
11. Fast, S., Nielsen, V.E., Bonnema, S.J. et al. (2009) Time to reconsider nonsurgical therapy of benign non-toxic multinodular goitre: focus on recombinant human TSH augmented radioiodine therapy. European Journal of Endocrinology/European Federation of Endocrine Societies, 160, 517 528.
12. Giovanni, V., Arianna, L.G., Antonio, C. et al. (2002) The use of recombinant human TSH in the follow-up of differentiated thyroid cancer: experience from a large patient cohort in a single centre. Clinical Endocrinology, 56, 247 252.
13. Bonnema, S.J., Bertelsen, H., Mortensen, J. et al. (1999) The feasibility of high dose iodine 131 treatment as an alternative to surgery in patients with a very large goiter: effect on thyroid function and size and pulmonary function. Journal of Clinical Endocrinology and Metabolism, 84, 3636 3641.
14. Nygaard, B., Faber, J. Hegedus, L. (1994) Acute changes in thyroid volume and function following 131I therapy of multinodular goitre. Clinical Endocrinology, 41, 715 718.
15. Pena, S., Arum, S., Cross, M. et al. (2006) 123I thyroid uptake and thyroid size at 24, 48, and 72 h after the administration of recombinant human thyroid-stimulating hormone to normal volunteers. Journal of Clinical Endocrinology and Metabolism, 91, 506 510.
16. Hegedus, L., Karstrup, S. Rasmussen, N. (1986) Evidence of cyclic alterations of thyroid size during the menstrual cycle in healthy women. American Journal of Obstetrics and Gynecology, 155, 142 145.
17. Hegedus, L., Perrild, H., Poulsen, L.R. et al. (1983) The determination of thyroid volume by ultrasound and its relationship to body weight, age, and sex in normal subjects. Journal of Clinical Endocrinology and Metabolism, 56, 260 263.
18. Andermann, P., Schlogl, S., Mader, U. et al. (2007) Intra- and interobserver variability of thyroid volume measurements in healthy adults by 2D versus 3D ultrasound. Nuklearmedizin, 46, 1 7.
19. Bonnema, S.J., Nielsen, V.E., Boel-Jorgensen, H. et al. (2008) Recombinant human thyrotropin-stimulated radioiodine therapy of large nodular goiters facilitates tracheal decompression and improves inspiration. Journal of Clinical Endocrinology and Metabolism, 93, 3981 3984.
20. Hegedus, L., Bonnema, S.J. Bennedbaek, F.N. (2003) Management of simple nodular goiter: current status and future perspectives. Endocrine Reviews, 24, 102 132.
21. Duick, D.S. Baskin, H.J. (2004) Significance of radioiodine uptake at 72 h versus 24 h after pretreatment with recombinant human thyrotropin for enhancement of radioiodine therapy in patients with symptomatic nontoxic or toxic multinodular goiter. Endocrine Practice, 10, 253 260.
22. Huysmans, D.A., Nieuwlaat, W.A., Erdtsieck, R.J. et al. (2000) Administration of a single low dose of recombinant human thyrotropin significantly enhances thyroid radioiodide uptake in nontoxic nodular goiter. Journal of Clinical Endocrinology and Metabolism, 85, 3592 3596.
23. Bennedbaek, F.N., Gram, J. Hegedus, L. (1996) The transition of subacute thyroiditis to Graves' disease as evidenced by diagnostic imaging. Thyroid, 6, 457 459.
24. Cohen, O., Ilany, J., Hoffman, C. et al. (2006) Low-dose recombinant human thyrotropin-aided radioiodine treatment of large, multinodular goiters in elderly patients. European Journal of Endocrinology/European Federation of Endocrine Societies, 154, 243 252.
25. Cubas, E.R., Paz-Filho, G.J., Olandoski, M. et al. (2009) Recombinant human TSH increases the efficacy of a fixed activity of radioiodine for treatment of multinodular goitre. International Journal of Clinical Practice, 63, 583 590.