Thyroid nodule guidelines: Agreement, disagreement and need for future research

Nature Reviews Endocrinology

Volumn 7, Issue 6, 2011, Pages 354-361

  Paschke, Ralf ^a   Hegedüs, Laszlo ^b   Alexander, Erik ^c   Valcavi, Roberto ^d   Papini, Enrico ^e   Gharib, Hossein ^f  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d S MARIA NUOVA HOSPITAL   (Italy)

^e REGINA APOSTOLORUM HOSPITAL   (Italy)

^f MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CALCITONIN; LEVOTHYROXINE; RAS PROTEIN;

ASPIRATION BIOPSY; CYTOLOGY; GENE MUTATION; LABORATORY TEST; PRIORITY JOURNAL; REVIEW; SCINTIGRAPHY; SCREENING; THYROID NODULE; ULTRASOUND;

BIOMEDICAL RESEARCH; BIOPSY, FINE-NEEDLE; CONSENSUS; DISSENT AND DISPUTES; FORECASTING; HEALTH SERVICES NEEDS AND DEMAND; HUMANS; PRACTICE GUIDELINES AS TOPIC; THYROID NODULE;

EID: 79957569526     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2011.1     Document Type: Review

References (63)

1. Guidelines for the managment of thyroid cancer. British Thyroid Association http://www.british-thyroid- association.org/news/Docs/Thyroid- cancer-guidelines-2007.pdf (2007).
2. Pacini, F. et al. European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium. Eur. J. Endocrinol. 154, 787-803 (2006).
3. Pitman, M. B. et al. Techniques for thyroid FNA: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference. Diagn. Cytopathol. 36, 407-424 (2008).
4. Camargo, R. et al. Latin American Thyroid Association recommendations for the management of thyroid nodules. Arq. Bras. Endocrinol. Metabol. 53, 1167-1175 (2009).
5. Wemeau, J.-L. et al. Recommandations pour la prise en charge des nodules thyroïdiens [French]. La Presse Medicale (in press).
6. Cooper, D. S. et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 19, 1167-1214 (2009).
7. Gharib, H. et al. American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association Medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. Endocr. Pract. 16 (Suppl. 1), 1-43 (2010).
8. Gharib, H., Papini, E. & Paschke, R. Thyroid nodules: a review of current guidelines, practices, and prospects. Eur. J. Endocrinol. 159, 493-505 (2008).
9. Boelaert, K. et al. Serum thyrotropin concentration as a novel predictor of malignancy in thyroid nodules investigated by fine-needle aspiration. J. Clin. Endocrinol. Metab. 91, 4295-4301 (2006).
10. Cheung, K., Roman, S. A., Wang, T. S., Walker, H. D. & Sosa, J. A. Calcitonin measurement in the evaluation of thyroid nodules in the United States: a cost-effectiveness and decision analysis. J. Clin. Endocrinol. Metab. 93, 2173-2180 (2008).
11. Costante, G., Durante, C., Francis, Z., Schlumberger, M. & Filetti, S. Determination of calcitonin levels in C-cell disease: clinical interest and potential pitfalls. Nat. Clin. Pract. Endocrinol. Metab. 5, 35-44 (2009).
12. Elisei, R. et al. Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: experience in 10,864 patients with nodular thyroid disorders. J. Clin. Endocrinol. Metab. 89, 163-168 (2004).
13. Bonavita, J. A. et al. Pattern recognition of benign nodules at ultrasound of the thyroid: which nodules can be left alone? AJR Am. J. Roentgenol. 193, 207-213 (2009).
14. Frates, M. C. et al. Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. J. Clin. Endocrinol. Metab. 91, 3411-3417 (2006).
15. Kim, E. K. et al. New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid. AJR Am. J. Roentgenol. 178, 687-691 (2002).
16. Kumar, H. et al. Gender, clinical findings, and serum thyrotropin measurements in the prediction of thyroid neoplasia in 1005 patients presenting with thyroid enlargement and investigated by fine-needle aspiration cytology. Thyroid 9, 1105-1109 (1999).
17. Moon, W. J. et al. Benign and malignant thyroid nodules: US differentiation-multicenter retrospective study. Radiology 247, 762-770 (2008).
18. Papini, E. et al. Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features. J. Clin. Endocrinol. Metab. 87, 1941-1946 (2002).
19. Ippolito, A. M. et al. Neural network analysis for evaluating cancer risk in thyroid nodules with an indeterminate diagnosis at aspiration cytology: identification of a low-risk subgroup. Thyroid 14, 1065-1071 (2004).
20. Leenhardt, L. et al. Selection of patients with solitary thyroid nodules for operation. Eur. J. Surg. 168, 236-241 (2002).
21. Okamoto, T. et al. Test performances of three diagnostic procedures in evaluating thyroid nodules: physical examination, ultrasonography and fine needle aspiration cytology. Endocr. J. 41, 243-247 (1994).
22. Rago, T., Santini, F., Scutari, M., Pinchera, A. & Vitti, P. Elastography: new developments in ultrasound for predicting malignancy in thyroid nodules. J. Clin. Endocrinol. Metab. 92, 2917-2922 (2007).
23. Cosgrove, D. Future prospects for SonoVue and CPS. Eur. Radiol. 14 (Suppl. 8), P116-P124 (2004).
24. Laurberg, P., Pedersen, K. M., Vestergaard, H. & Sigurdsson, G. High incidence of multinodular toxic goitre in the elderly population in a low iodine intake area vs. high incidence of Graves' disease in the young in a high iodine intake area: comparative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland. J. Intern. Med. 229, 415-420 (1991).
25. Krohn, K. et al. Molecular pathogenesis of euthyroid and toxic multinodular goiter. Endocr. Rev. 26, 504-524 (2005).
26. Sandrock, D., Olbricht, T., Emrich, D., Benker, G. & Reinwein, D. Long-term follow-up in patients with autonomous thyroid adenoma. Acta Endocrinol. (Copenh.) 128, 51-55 (1993).
27. Zhang, S. et al. Thin core needle biopsy crush preparations in conjunction with fine-needle aspiration for the evaluation of thyroid nodules: a complementary approach. Cancer 114, 512-518 (2008).
28. Danese, D., Sciacchitano, S., Farsetti, A., Andreoli, M. & Pontecorvi, A. Diagnostic accuracy of conventional versus sonography-guided fine-needle aspiration biopsy of thyroid nodules. Thyroid 8, 15-21 (1998).
29. Yang, J., Schnadig, V., Logrono, R. & Wasserman, P. G. Fine-needle aspiration of thyroid nodules: a study of 4703 patients with histologic and clinical correlations. Cancer 111, 306-315 (2007).
30. Yassa, L. et al. Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation. Cancer 111, 508-516 (2007).
31. Castro, M. R., Caraballo, P. J. & Morris, J. C. Effectiveness of thyroid hormone suppressive therapy in benign solitary thyroid nodules: a meta-analysis. J. Clin. Endocrinol. Metab. 87, 4154-4159 (2002).
32. Richter, B., Neises, G. & Clar, C. Pharmacotherapy for thyroid nodules. A systematic review and meta-analysis. Endocrinol. Metab. Clin. North Am. 31, 699-722 (2002).
33. Zelmanovitz, F., Genro, S. & Gross, J. L. Suppressive therapy with levothyroxine for solitary thyroid nodules: a double-blind controlled clinical study and cumulative meta-analyses. J. Clin. Endocrinol. Metab. 83, 3881-3885 (1998).
34. Goellner, J. R., Gharib, H., Grant, C. S. & Johnson, D. A. Fine needle aspiration cytology of the thyroid, 1980 to 1986. Acta Cytol. 31, 587-590 (1987).
35. Kini, S. R. Thyroid Cytopathology: an Atlas and Text 17-26 (Lippincott Williams & Wilkins, Philadelphia, 2008).
36. Eszlinger, M. et al. Perspectives for improved and more accurate classification of thyroid epithelial tumors. J. Clin. Endocrinol. Metab. 93, 3286-3294 (2008).
37. Eszlinger, M. & Paschke, R. Molecular fine-needle aspiration biopsy diagnosis of thyroid nodules by tumor specific mutations and gene expression patterns. Mol. Cell Endocrinol. 322, 29-37 (2010).
38. Nikiforova, M. N. & Nikiforov, Y. E. Molecular diagnostics and predictors in thyroid cancer. Thyroid 19, 1351-1361 (2009).
39. Freitas, B. C. & Cerutti, J. M. Genetic markers differentiating follicular thyroid carcinoma from benign lesions. Mol. Cell Endocrinol. 321, 77-85 (2010).
40. Gharib, H. & Papini, E. Thyroid nodules: clinical importance, assessment, and treatment. Endocrinol. Metab. Clin. North Am. 36, 707-735 (2007).
41. Wesche, M. F., Tiel-V Buul, M. M., Lips, P., Smits, N. J. & Wiersinga, W. M. A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter. J. Clin. Endocrinol. Metab. 86, 998-1005 (2001).
42. Surks, M. I. et al. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA 291, 228-238 (2004).
43. Fast, S., Bonnema, S. J. & Hegedüs, L. The majority of Danish nontoxic goitre patients are ineligible for Levothyroxine suppressive therapy. Clin. Endocrinol. (Oxf.) 69, 653-658 (2008).
44. Hegedüs, L. Clinical practice. The thyroid nodule. N. Engl. J. Med. 351, 1764-1771 (2004).
45. Nygaard, B., Hegedüs, L., Nielsen, K. G., Ulriksen, P. & Hansen, J. M. Long-term effect of radioactive iodine on thyroid function and size in patients with solitary autonomously functioning toxic thyroid nodules. Clin. Endocrinol. (Oxf.) 50, 197-202 (1999).
46. Nygaard, B. et al. Radioiodine treatment of multinodular non-toxic goitre. BMJ 307, 828-832 (1993).
47. Bonnema, S. J. et al. Improvement of goiter volume reduction after 0.3 mg recombinant human thyrotropin-stimulated radioiodine therapy in patients with a very large goiter: a double-blinded, randomized trial. J. Clin. Endocrinol. Metab. 92, 3424-3428 (2007).
48. Nielsen, V. E., Bonnema, S. J., Jørgensen, H. B., Grupe, P. & Hegedüs, L. Stimulation with 0,3 mg recombinant human thyrotropin (rhTSH) increases the effect of 131I therapy in patients with nontoxic nodular goiter. A prospective, randomized, double-blind trial - secondary publication. Ugeskr. Laeger 168, 4098-4101 (2006).
49. Fast, S. et al. Recombinant human thyrotropin-stimulated radioiodine therapy of nodular goiter allows major reduction of the radiation burden with retained efficacy. J. Clin. Endocrinol. Metab. 95, 3719-3725 (2010).
50. Bennedbaek, F. N. & Hegedüs, L. Treatment of recurrent thyroid cysts with ethanol: a randomized double-blind controlled trial. J. Clin. Endocrinol. Metab. 88, 5773-5777 (2003).
51. Valcavi, R. & Frasoldati, A. Ultrasound-guided percutaneous ethanol injection therapy in thyroid cystic nodules. Endocr. Pract. 10, 269-275 (2004).
52. Verde, G. et al. Ultrasound guided percutaneous ethanol injection in the treatment of cystic thyroid nodules. Clin. Endocrinol. (Oxf.) 41, 719-724 (1994).
53. Bennedbaek, F. N., Nielsen, L. K. & Hegedüs, L. Effect of percutaneous ethanol injection therapy versus suppressive doses of L-thyroxine on benign solitary solid cold thyroid nodules: a randomized trial. J. Clin. Endocrinol. Metab. 83, 830-835 (1998).
54. Lippi, F. et al. Treatment of solitary autonomous thyroid nodules by percutaneous ethanol injection: results of an Italian multicenter study. The Multicenter Study Group. J. Clin. Endocrinol. Metab. 81, 3261-3264 (1996).
55. Livraghi, T. et al. Treatment of autonomous thyroid nodules with percutaneous ethanol injection: 4-year experience. Radiology 190, 529-533 (1994).
56. Papini, E. et al. Treatment of benign cold thyroid nodules: a randomized clinical trial of percutaneous laser ablation versus levothyroxine therapy or follow-up. Thyroid 17, 229-235 (2007).
57. Døssing, H., Bennedbaek, F. N. & Hegedüs, L. Effect of ultrasound-guided interstitial laser photocoagulation on benign solitary solid cold thyroid nodules - a randomised study. Eur. J. Endocrinol. 152, 341-345 (2005).
58. Døssing, H., Bennedbaek, F. N. & Hegedüs, L. Effect of ultrasound-guided interstitial laser photocoagulation on benign solitary solid cold thyroid nodules: one versus three treatments. Thyroid 16, 763-768 (2006).
59. Valcavi, R., Riganti, F., Bertani, A., Formisano, D. & Pacella, C. M. Percutaneous laser ablation of cold benign thyroid nodules: a 3-year follow-up study in 122 patients. Thyroid 20, 1253-1261 (2010).
60. Spiezia, S. et al. Thyroid nodules and related symptoms are stably controlled two years after radiofrequency thermal ablation. Thyroid 19, 219-225 (2009).
61. Kwak, J. Y. et al. The role of ultrasound in thyroid nodules with a cytology reading of "suspicious for papillary thyroid carcinoma". Thyroid 18, 517-522 (2008).
62. Schlinkert, R. T. et al. Factors that predict malignant thyroid lesions when fine-needle aspiration is "suspicious for follicular neoplasm". Mayo Clin. Proc. 72, 913-916 (1997).
63. Alexander, E. K. Approach to the patient with a cytologically indeterminate thyroid nodule. J. Clin. Endocrinol. Metab. 93, 4175-4182 (2008).