The amyloid precursor protein forms plasmalemmal clusters via its pathogenic amyloid-β domain

Biophysical Journal

Volumn 102, Issue 6, 2012, Pages 1411-1417

  Schreiber, Arne ^a   Fischer, Sebastian ^a   Lang, Thorsten ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CLATHRIN; MUTANT PROTEIN;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL MEMBRANE; CELL STRAIN; CELL STRAIN HEPG2; CHEMISTRY; EXTRACELLULAR SPACE; HUMAN; INTRACELLULAR SPACE; METABOLISM; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; RAT; STRUCTURE ACTIVITY RELATION;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELL MEMBRANE; CLATHRIN; EXTRACELLULAR SPACE; HEP G2 CELLS; HUMANS; INTRACELLULAR SPACE; MODELS, BIOLOGICAL; MUTANT PROTEINS; PC12 CELLS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84858763470     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2012.02.031     Document Type: Article

References (32)

1. Q.X. Li, and S.J. Fuller C.L. Masters The amyloid precursor protein of Alzheimer disease in human brain and blood J. Leukoc. Biol. 66 1999 567 574 (Pubitemid 29489881)
2. D.M. Walsh, and D.J. Selkoe A β oligomers - a decade of discovery J. Neurochem. 101 2007 1172 1184
3. R.J. O'Brien, and P.C. Wong Amyloid precursor protein processing and Alzheimer's disease Annu. Rev. Neurosci. 34 2011 185 204
4. X. He, and K. Cooley J. Tang Apolipoprotein receptor 2 and X11 α/β mediate apolipoprotein E-induced endocytosis of amyloid-β precursor protein and β-secretase, leading to amyloid-β production J. Neurosci. 27 2007 4052 4060 (Pubitemid 46597171)
5. A. Kinoshita, and H. Fukumoto B.T. Hyman Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes J. Cell Sci. 116 2003 3339 3346 (Pubitemid 37038982)
6. L. Rajendran, and M. Honsho K. Simons Alzheimer's disease β-amyloid peptides are released in association with exosomes Proc. Natl. Acad. Sci. USA 103 2006 11172 11177 (Pubitemid 44156491)
7. M. Sakono, and T. Zako Amyloid oligomers: formation and toxicity of Aβ oligomers FEBS J. 277 2010 1348 1358
8. R. Baruch-Suchodolsky, and B. Fischer Aβ40, either soluble or aggregated, is a remarkably potent antioxidant in cell-free oxidative systems Biochemistry 48 2009 4354 4370
9. U. Igbavboa, and G.Y. Sun W.G. Wood Amyloid β-protein stimulates trafficking of cholesterol and caveolin-1 from the plasma membrane to the Golgi complex in mouse primary astrocytes Neuroscience 162 2009 328 338
10. K. Zou, and J.S. Gong M. Michikawa A novel function of monomeric amyloid β-protein serving as an antioxidant molecule against metal-induced oxidative damage J. Neurosci. 22 2002 4833 4841 (Pubitemid 37465598)
11. P.J. Tienari, and B. De Strooper C.G. Dotti The β-amyloid domain is essential for axonal sorting of amyloid precursor protein EMBO J. 15 1996 5218 5229 (Pubitemid 26336205)
12. J.R. Cirrito, and J.E. Kang D.M. Holtzman Endocytosis is required for synaptic activity-dependent release of amyloid-β in vivo Neuron 58 2008 42 51 (Pubitemid 351467029)
13. R. Vassar, and D.M. Kovacs P.C. Wong The β-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential J. Neurosci. 29 2009 12787 12794
14. R.M. Carey, and B.A. Balcz B.E. Slack Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid β protein BMC Cell Biol. 6 2005 30
15. C. Nordstedt, and G.L. Caporaso P. Greengard Identification of the Alzheimer β/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells J. Biol. Chem. 268 1993 608 612 (Pubitemid 23021365)
16. A. Schneider, and L. Rajendran M. Simons Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons J. Neurosci. 28 2008 2874 2882 (Pubitemid 351398889)
17. P. Soba, and S. Eggert K. Beyreuther Homo- and heterodimerization of APP family members promotes intercellular adhesion EMBO J. 24 2005 3624 3634 (Pubitemid 41509369)
18. 2+ induces clustering of membrane proteins in the plasma membrane via electrostatic interactions EMBO J. 30 2011 1209 1220
19. A.K. Kenworthy, and B.J. Nichols J. Lippincott-Schwartz Dynamics of putative raft-associated proteins at the cell surface J. Cell Biol. 165 2004 735 746 (Pubitemid 38765774)
20. K. Nakamura, and A. Watakabe T. Kaneko Transiently increased colocalization of vesicular glutamate transporters 1 and 2 at single axon terminals during postnatal development of mouse neocortex: a quantitative analysis with correlation coefficient Eur. J. Neurosci. 26 2007 3054 3067 (Pubitemid 350135158)
21. T. Lang, and M. Margittai R. Jahn SNAREs in native plasma membranes are active and readily form core complexes with endogenous and exogenous SNAREs J. Cell Biol. 158 2002 751 760 (Pubitemid 34920113)
22. H.T. He, and D. Marguet Detecting nanodomains in living cell membrane by fluorescence correlation spectroscopy Annu. Rev. Phys. Chem. 62 2011 417 436
23. P. Phlsson, S.H. Shakin-Eshleman, and S.L. Spitalnik N-linked glycosylation of β-amyloid precursor protein Biochem. Biophys. Res. Commun. 189 1992 1667 1673 (Pubitemid 23041354)
24. I. Perdivara, and R. Petrovich M. Przybylski Elucidation of O-glycosylation structures of the β-amyloid precursor protein by liquid chromatography-mass spectrometry using electron transfer dissociation and collision induced dissociation J. Proteome Res. 8 2009 631 642
25. A. Kusumi, and C. Nakada T. Fujiwara Paradigm shift of the plasma membrane concept from the two-dimensional continuum fluid to the partitioned fluid: high-speed single-molecule tracking of membrane molecules Annu. Rev. Biophys. Biomol. Struct. 34 2005 351 378 (Pubitemid 40847729)
26. L. Rajendran, and A. Schneider K. Simons Efficient inhibition of the Alzheimer's disease β-secretase by membrane targeting Science 320 2008 520 523 (Pubitemid 351590663)
27. J. Prox, A. Rittger, and P. Saftig Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin Exp Brain Res. 2011 10.1007/s00221-011-2952-0 Epub ahead of print November 27, 2011
28. L.-M. Munter, and P. Voigt G. Multhaup GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42 EMBO J. 26 2007 1702 1712 (Pubitemid 46480941)
29. C. Reinhard, S.S. Hébert, and B. De Strooper The amyloid-beta precursor protein: integrating structure with biological function EMBO J. 24 2005 3996 4006 (Pubitemid 41752869)
30. D. Beher, and L. Hesse G. Multhaup Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I J. Biol. Chem. 271 1996 1613 1620 (Pubitemid 26028652)
31. S. Scheuermann, and B. Hambsch G. Multhaup Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease J. Biol. Chem. 276 2001 33923 33929
32. Y. Wang, and Y. Ha The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain Mol. Cell 15 2004 343 353 (Pubitemid 39092751)