메뉴 건너뛰기




Volumn 7, Issue 1, 1998, Pages 61-72

Melatonin involvement in immunity and cancer

Author keywords

Extrapineal synthesis; Immune system; Melatonin; Neoplastic growth; Photoperiod; Seasonality

Indexed keywords

INTERLEUKIN 2; MELATONIN;

EID: 0031802340     PISSN: 1424862X     EISSN: 14248638     Source Type: Journal    
DOI: 10.1159/000014529     Document Type: Article
Times cited : (53)

References (131)
  • 1
    • 0024532757 scopus 로고
    • A molecular basis for bidirectional communication between the immune and neuroendocrine systems
    • Blalock JE: A molecular basis for bidirectional communication between the immune and neuroendocrine systems. Physiol Rev 1989;69: 1-32.
    • (1989) Physiol Rev , vol.69 , pp. 1-32
    • Blalock, J.E.1
  • 2
    • 0026041631 scopus 로고
    • Pineal melatonin inhibition of tumor promotion in the N-nitroso-N-methyl-urea model of mammary carcinogenesis: Potential involvement of antiestrogenic mechanisms in vivo
    • Blask D, Pelletier D, Hill S, Lemus-Wilson A, Grosso D, Wilson S, Wise M: Pineal melatonin inhibition of tumor promotion in the N-nitroso-N-methyl-urea model of mammary carcinogenesis: Potential involvement of antiestrogenic mechanisms in vivo. J Cancer Res Clin Oncol 1991;117:526-532.
    • (1991) J Cancer Res Clin Oncol , vol.117 , pp. 526-532
    • Blask, D.1    Pelletier, D.2    Hill, S.3    Lemus-Wilson, A.4    Grosso, D.5    Wilson, S.6    Wise, M.7
  • 4
    • 0022462221 scopus 로고
    • Role of the pineal gland in immunity: Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone
    • Maestroni GJ, Conti A, Pierpaoli W: Role of the pineal gland in immunity: Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone. J Neuroimmunol 1986; 13:19-30.
    • (1986) J Neuroimmunol , vol.13 , pp. 19-30
    • Maestroni, G.J.1    Conti, A.2    Pierpaoli, W.3
  • 5
    • 0026668767 scopus 로고
    • Effect of tryptophan administration on circulating melatonin levels in chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract
    • Huether G, Poeggeler B, Reimer A, George A: Effect of tryptophan administration on circulating melatonin levels in chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract. Life Sci 1992;51:945-953.
    • (1992) Life Sci , vol.51 , pp. 945-953
    • Huether, G.1    Poeggeler, B.2    Reimer, A.3    George, A.4
  • 7
    • 0024235361 scopus 로고
    • Serotonin and melatonin synthesis in peripheral blood mononuclear cells, stimulation by interferon gamma as part of an immunomodulatory pathway
    • Finocchiaro LM, Artz ES, Fernan-dez-Castelo S, Criscuolo M, Finkiel-man S, Nahmod VE: Serotonin and melatonin synthesis in peripheral blood mononuclear cells, stimulation by interferon gamma as part of an immunomodulatory pathway. J Interferon Res 1988;8:705-716.
    • (1988) J Interferon Res , vol.8 , pp. 705-716
    • Finocchiaro, L.M.1    Artz, E.S.2    Fernan-Dezcastelo, S.3    Criscuolo, M.4    Finkiel-Man, S.5    Nahmod, V.E.6
  • 8
    • 0026343791 scopus 로고
    • Melatonin biosynthesis and metabolism in peripheral blood mononuclear leukocytes
    • Finocchiaro LM, Nahmod VE, Launay JM: Melatonin biosynthesis and metabolism in peripheral blood mononuclear leukocytes. Biochem J 1991;280:727-731.
    • (1991) Biochem J , vol.280 , pp. 727-731
    • Finocchiaro, L.M.1    Nahmod, V.E.2    Launay, J.M.3
  • 9
    • 0029113058 scopus 로고
    • Sensitivity of human peripheral blood mononuclear leukocytes to visible light
    • Finocchiaro LM, Polack E, Nahmod VE, Glikin GC: Sensitivity of human peripheral blood mononuclear leukocytes to visible light. Life Sci 1995;57:1097-1110.
    • (1995) Life Sci , vol.57 , pp. 1097-1110
    • Finocchiaro, L.M.1    Polack, E.2    Nahmod, V.E.3    Glikin, G.C.4
  • 10
    • 0025915557 scopus 로고
    • Melatonin: The chemical expression of darkness
    • Reiter RJ: Melatonin: The chemical expression of darkness. Mol Cell Endocrinol 1991;79:C153-C158.
    • (1991) Mol Cell Endocrinol , vol.79 , pp. C153-C158
    • Reiter, R.J.1
  • 11
    • 0024396596 scopus 로고
    • Mammalian pineal melatonin: A clock for all seasons
    • Bartness TJ, Goldman BD: Mammalian pineal melatonin: A clock for all seasons. Experientia 1989;45: 939-945.
    • (1989) Experientia , vol.45 , pp. 939-945
    • Bartness, T.J.1    Goldman, B.D.2
  • 17
    • 0029401790 scopus 로고
    • The influence of season, photoperiod, and pineal melatonin on immune function
    • Nelson RJ, Demas GE, Klein SL, Kriegsfeld LJ: The influence of season, photoperiod, and pineal melatonin on immune function. J Pineal Res 1995;19:149-165.
    • (1995) J Pineal Res , vol.19 , pp. 149-165
    • Nelson, R.J.1    Demas, G.E.2    Klein, S.L.3    Kriegsfeld, L.J.4
  • 19
    • 84939690567 scopus 로고
    • Hormonal relationship of mastocyto-genesis in lymphatic organs. II. Effect of epiphysectomy on the genesis of mast cells
    • Csaba G, Bodoky M, Toro I: Hormonal relationship of mastocyto-genesis in lymphatic organs. II. Effect of epiphysectomy on the genesis of mast cells. Acta Anat (Basel) 1965;61:289-296.
    • (1965) Acta Anat (Basel) , vol.61 , pp. 289-296
    • Csaba, G.1    Bodoky, M.2    Toro, I.3
  • 20
    • 0016663618 scopus 로고
    • Morphological changes of thymus and the thyroid gland after postnatal extirpation of pineal body
    • Csaba G, Barath P: Morphological changes of thymus and the thyroid gland after postnatal extirpation of pineal body. Endocrinol Exp 1975; 9:59-67.
    • (1975) Endocrinol Exp , vol.9 , pp. 59-67
    • Csaba, G.1    Barath, P.2
  • 21
    • 0014707999 scopus 로고
    • Effects of pinealectomy on immune reaction in the rat
    • Jankovic D, Isakovic K, Petrovic S: Effects of pinealectomy on immune reaction in the rat. Immunol 1970; 18:1-6.
    • (1970) Immunol , vol.18 , pp. 1-6
    • Jankovic, D.1    Isakovic, K.2    Petrovic, S.3
  • 22
    • 0001591250 scopus 로고
    • Pharmacologic control of the hormonally mediated immune response
    • Ader R (ed):, London, Academic Press
    • Maestroni GJ, Pierpaoli W: Pharmacologic control of the hormonally mediated immune response; in Ader R (ed): Psychoneuroimmunology. London, Academic Press, 1981, pp 405-413.
    • (1981) Psychoneuroimmunology. , pp. 405-413
    • Maestroni, G.J.1    Pierpaoli, W.2
  • 23
    • 0022462221 scopus 로고
    • Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone
    • Maestroni GJ, Conti A, Pierpaoli W: Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone. J Neuroimmunol 1986; 13:19-30.
    • (1986) J Neuroimmunol , vol.13 , pp. 19-30
    • Maestroni, G.J.1    Conti, A.2    Pierpaoli, W.3
  • 24
    • 85025573348 scopus 로고
    • Preliminary results regarding a possible immunomodulatory effect of melatonin in B16 tumor bearing mice
    • Jerusalem
    • Franco P, Scaglione F, Marelli O, Ricci L, Ferrara F, Fraschini F: Preliminary results regarding a possible immunomodulatory effect of melatonin in B16 tumor bearing mice. Proc 16th Int Congr Chemother, Jerusalem, 1989, pp 897.1-897.2.
    • (1989) Proc 16Th Int Congr Chemother , pp. 1-897
    • Franco, P.1    Scaglione, F.2    Marelli, O.3    Ricci, L.4    Ferrara, F.5    Fraschini, F.6
  • 25
    • 0027285368 scopus 로고
    • The relationship between opioids and melatonin in the immune system
    • Garza HH Jr, Stankov B, Fraschini F, Carr DJJ: The relationship between opioids and melatonin in the immune system. Neuroendocrinol Lett 1993;15:135-148.
    • (1993) Neuroendocrinol Lett , vol.15 , pp. 135-148
    • Garza, H.H.1    Stankov, B.2    Fraschini, F.3    Carr, D.4
  • 26
    • 0023933347 scopus 로고
    • Role of the pineal gland in immunity. III. Melatonin antagonizes the immunosuppressive effect of acute stress via an opiatergic mechanism
    • Maestroni GJ, Conti A, Pierpaoli W: Role of the pineal gland in immunity. III. Melatonin antagonizes the immunosuppressive effect of acute stress via an opiatergic mechanism. Immunology 1988;63:465-469.
    • (1988) Immunology , vol.63 , pp. 465-469
    • Maestroni, G.J.1    Conti, A.2    Pierpaoli, W.3
  • 27
    • 0023220672 scopus 로고
    • Role of the pineal gland in immunity. II. Melatonin enhances the antibody response via an opiatergic mechanism
    • Maestroni GJ, Conti A, Pierpaoli W: Role of the pineal gland in immunity. II. Melatonin enhances the antibody response via an opiatergic mechanism. Clin Exp Immunol 1987;68:384-391.
    • (1987) Clin Exp Immunol , vol.68 , pp. 384-391
    • Maestroni, G.J.1    Conti, A.2    Pierpaoli, W.3
  • 28
    • 0024361174 scopus 로고
    • P-Endor-phin and dynorphin mimic the circadian immunoenhancing and antistress effect of melatonin
    • Maestroni GJ, Conti A: P-Endor-phin and dynorphin mimic the circadian immunoenhancing and antistress effect of melatonin. Int J Im-munopharmacol 1989;11:333-340.
    • (1989) Int J Im-Munopharmacol , vol.11 , pp. 333-340
    • Maestroni, G.J.1    Conti, A.2
  • 29
    • 0025374954 scopus 로고
    • The pineal neurohormone melatonin stimulates activated CD4+, Thy-1+ cells to release opioid agonist(S) with im-munoenhancing and anti-stress properties
    • Maestroni GJ, Conti A: The pineal neurohormone melatonin stimulates activated CD4+, Thy-1+ cells to release opioid agonist(s) with im-munoenhancing and anti-stress properties. J Neuroimmunol 1990; 28:167-176.
    • (1990) J Neuroimmunol , vol.28 , pp. 167-176
    • Maestroni, G.J.1    Conti, A.2
  • 30
    • 0026289450 scopus 로고
    • Anti-stress role of the melatonin-opioid-network: Evidence for a physiological mechanism involving T cell derived, immunoreactive P-endorphin and Met-enkephalin binding to thymic opioid receptors
    • Maestroni GJ, Conti A: Anti-stress role of the melatonin-opioid-network: Evidence for a physiological mechanism involving T cell derived, immunoreactive P-endorphin and Met-enkephalin binding to thymic opioid receptors. Int J Neurosci 1991;61:289-298.
    • (1991) Int J Neurosci , vol.61 , pp. 289-298
    • Maestroni, G.J.1    Conti, A.2
  • 31
    • 0029609018 scopus 로고
    • Melatonin affects proopiomelanocortin gene expression in the immune organs of the rat
    • Wajs E, Kutoh E, Gupta D: Melatonin affects proopiomelanocortin gene expression in the immune organs of the rat. Eur J Endocrinol 1995;133:754-760.
    • (1995) Eur J Endocrinol , vol.133 , pp. 754-760
    • Wajs, E.1    Kutoh, E.2    Gupta, D.3
  • 32
    • 0024595456 scopus 로고
    • Characterization of opiate binding sites on membranes of rat lymphocytes
    • Ovadia H, Nitsan P, Abramsky O: Characterization of opiate binding sites on membranes of rat lymphocytes. J Neuroimmunol 1989;21: 93-102.
    • (1989) J Neuroimmunol , vol.21 , pp. 93-102
    • Ovadia, H.1    Nitsan, P.2    Abramsky, O.3
  • 33
    • 0029822790 scopus 로고    scopus 로고
    • Kappa opioid receptors on immune cells as studied by fluorescent ligands
    • Bidlack JM, Lawrence DMP, Igna-towski TA: Kappa opioid receptors on immune cells as studied by fluorescent ligands. Adv Exp Med Biol 1996;402:13-22.
    • (1996) Adv Exp Med Biol , vol.402 , pp. 13-22
    • Bidlack, J.M.1    Lawrence, D.2    Igna-Towski, T.A.3
  • 34
    • 0024451928 scopus 로고
    • Pinealectomy inhibits interleukin-2 production and natural killer activity in mice
    • Del Gobbo V, Libri V, Villani R, Calib G, Nistico G: Pinealectomy inhibits interleukin-2 production and natural killer activity in mice. Int J Immunopharmacol 1989; 11: 567-577.
    • (1989) Int J Immunopharmacol , vol.11 , pp. 567-577
    • Del Gobbo, V.1    Libri, V.2    Villani, R.3    Calib, G.4    Nistico, G.5
  • 36
    • 0027300325 scopus 로고
    • Melatonin increases antigen presentation and amplified specific and non specific signals for T-cell proliferation
    • Pioli C, Caroleo MC, Nistico G, Doria G: Melatonin increases antigen presentation and amplified specific and non specific signals for T-cell proliferation. Int J Immunopharma-col 1993;15:463-469.
    • (1993) Int J Immunopharma-Col , vol.15 , pp. 463-469
    • Pioli, C.1    Caroleo, M.C.2    Nistico, G.3    Doria, G.4
  • 37
    • 0028075016 scopus 로고
    • Activation of human monocytes by the pineal hormone melatonin
    • Morrey MK, McLachlan JA, Serkin CD, Bakouche O: Activation of human monocytes by the pineal hormone melatonin. J Immunol 1994; 153:2671-2680.
    • (1994) J Immunol , vol.153 , pp. 2671-2680
    • Morrey, M.K.1    Mc Lachlan, J.A.2    Serkin, C.D.3    Bakouche, O.4
  • 38
    • 0026343791 scopus 로고
    • Melatonin biosynthesis and metabolism in peripheral blood mononuclear leukocytes
    • Finocchiaro LE, Nahmod E, Launay JM: Melatonin biosynthesis and metabolism in peripheral blood mononuclear leukocytes. Biochem J 1991; 280:727-732.
    • (1991) Biochem J , vol.280 , pp. 727-732
    • Finocchiaro, L.E.1    Nahmod, E.2    Launay, J.M.3
  • 39
    • 0027064617 scopus 로고
    • Immunological effects of a single evening subcutaneous injection of low dose interleukin-2 in association with the pineal hormone melatonin in advanced cancer patients
    • Lissoni P, Barni S, Ardizzoia A, Brivio F, Tancini G, Conti A, Maes-troni GJ: Immunological effects of a single evening subcutaneous injection of low dose interleukin-2 in association with the pineal hormone melatonin in advanced cancer patients. J Biol Regul Homeost Agents 1992;6:132-136.
    • (1992) J Biol Regul Homeost Agents , vol.6 , pp. 132-136
    • Lissoni, P.1    Barni, S.2    Ardizzoia, A.3    Brivio, F.4    Tancini, G.5    Conti, A.6    Maes-Troni, G.J.7
  • 41
    • 0027936784 scopus 로고
    • Colony-stimulating activity and hematopoietic rescue from cancer chemotherapy compounds are induced by melatonin via endogenous interleukin 4
    • Maestroni GJ, Conti A, Lissoni P: Colony-stimulating activity and hematopoietic rescue from cancer chemotherapy compounds are induced by melatonin via endogenous interleukin 4. Cancer Res 1994;54:4740-4743.
    • (1994) Cancer Res , vol.54 , pp. 4740-4743
    • Maestroni, G.J.1    Conti, A.2    Lissoni, P.3
  • 42
    • 0028270330 scopus 로고
    • Hematopoietic rescue via T-cell-de-pendent, endogenous granulocyte-macrophage colony-stimulating factor induced by the pineal neurohormone melatonin in tumor bearing mice
    • Maestroni GJ, Covacci V, Conti A: Hematopoietic rescue via T-cell-de-pendent, endogenous granulocyte-macrophage colony-stimulating factor induced by the pineal neurohormone melatonin in tumor bearing mice. Cancer Res 1994;54:2429-2432.
    • (1994) Cancer Res , vol.54 , pp. 2429-2432
    • Maestroni, G.J.1    Covacci, V.2    Conti, A.3
  • 43
    • 0009669810 scopus 로고    scopus 로고
    • New T helper cell opioid cytokines as mediators of the immunological and hematopoietic action of melatonin; in Maestroni GJ, Conti A, Reiter RJ (Eds): Therapeutic Potential of Melatonin. Front Horm Res. Basel
    • Maestroni JM, Hertens E, Galli P: New T helper cell opioid cytokines as mediators of the immunological and hematopoietic action of melatonin; in Maestroni GJ, Conti A, Reiter RJ (eds): Therapeutic Potential of Melatonin. Front Horm Res. Basel, Karger, 1997, vol 23, pp 6271.
    • (1997) Karger , vol.23 , pp. 6271
    • Maestroni, J.M.1    Hertens, E.2    Galli, P.3
  • 44
    • 0026502495 scopus 로고
    • Continuous in vivo treatment with catecholamines suppresses in vitro reactivity of rat peripheral blood T lymphocytes via • mediated mechanisms
    • Felsner P, Hofer D, Rinner I, Mangge H, Griber M, Korsatko W, Schauenstein K: Continuous in vivo treatment with catecholamines suppresses in vitro reactivity of rat peripheral blood T lymphocytes via • mediated mechanisms. J Neuroim-munol 1992;37:47-57.
    • (1992) J Neuroim-Munol , vol.37 , pp. 47-57
    • Felsner, P.1    Hofer, D.2    Rinner, I.3    Mangge, H.4    Griber, M.5    Korsatko, W.6    Schauenstein, K.7
  • 45
    • 0028933419 scopus 로고
    • Preliminary evidence of a synergistic a1- and p1-adrenoceptor regulation of rat pineal hydroxyindole-O-meth-yltransferase
    • McLeod SD, Cairncross KD: Preliminary evidence of a synergistic a1- and p1-adrenoceptor regulation of rat pineal hydroxyindole-O-meth-yltransferase. Gen Comp Endocrinol 1995;97:283-288.
    • (1995) Gen Comp Endocrinol , vol.97 , pp. 283-288
    • Mc Leod, S.D.1    Cairncross, K.D.2
  • 46
    • 0028939024 scopus 로고
    • Adrenergic suppression of peripheral blood T cell reactivity in the rat is due to activation of peripheral a2 receptors
    • Felsner P, Hofer D, Rinner I, Porta S, Korsatko W, Schauenstein K: Adrenergic suppression of peripheral blood T cell reactivity in the rat is due to activation of peripheral a2 receptors. J Neuroimmunol 1995; 57:27-34.
    • (1995) J Neuroimmunol , vol.57 , pp. 27-34
    • Felsner, P.1    Hofer, D.2    Rinner, I.3    Porta, S.4    Korsatko, W.5    Schauenstein, K.6
  • 47
    • 0030200143 scopus 로고    scopus 로고
    • Beta blockade enhances adrenergic immunosuppression in rats via inhibition of melatonin release
    • Liebmann PM, Hofer D, Felsner P, Wolfler A, Schauenstein K: Beta blockade enhances adrenergic immunosuppression in rats via inhibition of melatonin release. J Neu-roimmunol 1996;67:137-142.
    • (1996) J Neu-Roimmunol , vol.67 , pp. 137-142
    • Liebmann, P.M.1    Hofer, D.2    Felsner, P.3    Wolfler, A.4    Schauenstein, K.5
  • 48
    • 0025833853 scopus 로고
    • Melatonin-induced enhancement of anti-body-dependent cellular cytotoxicity
    • Giordano M, Palermo MS: Melatonin-induced enhancement of anti-body-dependent cellular cytotoxicity. J Pineal Res 1991;10:117-121.
    • (1991) J Pineal Res , vol.10 , pp. 117-121
    • Giordano, M.1    Palermo, M.S.2
  • 49
    • 0027194228 scopus 로고
    • Seasonal variation in antibody-dependent cellular cytotoxicity regulation by melatonin
    • Giordano M, Vermeulen M, Palermo MS: Seasonal variation in antibody-dependent cellular cytotoxicity regulation by melatonin. FASEB J 1993;7:1052-1054.
    • (1993) FASEB J , vol.7 , pp. 1052-1054
    • Giordano, M.1    Vermeulen, M.2    Palermo, M.S.3
  • 50
    • 0029565036 scopus 로고
    • Selective effect of methoxyindoles on the lymphocyte proliferation and melatonin binding to activated human lymphoid cells
    • Konakchieva R, Kyurkchiev S, Ke-hayov I, Taushanova P, Kanchev L: Selective effect of methoxyindoles on the lymphocyte proliferation and melatonin binding to activated human lymphoid cells. J Neuroimmu-nol 1995;63:125-132.
    • (1995) J Neuroimmu-Nol , vol.63 , pp. 125-132
    • Konakchieva, R.1    Kyurkchiev, S.2    Ke-Hayov, I.3    Taushanova, P.4    Kanchev, L.5
  • 51
    • 0029976012 scopus 로고    scopus 로고
    • Effect of melatonin on mitotic and proliferation indices, and sister chromatid exchange in human blood lymphocytes
    • Vijayalaxmi, Reiter RJ, Leal BZ, Meltz ML: Effect of melatonin on mitotic and proliferation indices, and sister chromatid exchange in human blood lymphocytes. Mutat Res 1996;351:187-192.
    • (1996) Mutat Res , vol.351 , pp. 187-192
    • Vijayalaxmi, R.R.1    Leal, B.Z.2    Meltz, M.L.3
  • 52
    • 0024241413 scopus 로고
    • Im-munomodulation by indoleamines: Serotonin and melatonin action on DNA and interferon-gamma synthesis by human peripheral blood mononuclear cells
    • Artz ES, Fernandez-Castelo S, Fi-nocchiaro LM, Criscuolo Me, Diaz A, Finkielman S, Nahmod VE: Im-munomodulation by indoleamines: Serotonin and melatonin action on DNA and interferon-gamma synthesis by human peripheral blood mononuclear cells. J Clin Immunol 1988;8:513-520.
    • (1988) J Clin Immunol , vol.8 , pp. 513-520
    • Artz, E.S.1    Fernandez-Castelo, S.2    Fi-Nocchiaro, L.M.3    Me, C.4    Diaz, A.5    Finkielman, S.6    Nahmod, V.E.7
  • 53
    • 0028535303 scopus 로고
    • Inhibitory effect of melatonin on production of IFN gamma or TNF alpha in peripheral blood mononuclear cells of some blood donors
    • Di Stefano A, Paulesu L: Inhibitory effect of melatonin on production of IFN gamma or TNF alpha in peripheral blood mononuclear cells of some blood donors. J Pineal Res 1994;17:164-169.
    • (1994) J Pineal Res , vol.17 , pp. 164-169
    • Di Stefano, A.1    Paulesu, L.2
  • 54
    • 0026752062 scopus 로고
    • A brief survey of pineal gland-immune system interrelationship
    • Guerrero JM, Reiter RJ: A brief survey of pineal gland-immune system interrelationship. Endocr Res 1992; 18:91-113.
    • (1992) Endocr Res , vol.18 , pp. 91-113
    • Guerrero, J.M.1    Reiter, R.J.2
  • 55
    • 0029285591 scopus 로고
    • Immunomodulatory role of melatonin: Specific binding sites in human and rodent lymphoid cells
    • Calvo JR, Rafii-el-Idrissi M, Pozo D, Guerrero JM: Immunomodulatory role of melatonin: Specific binding sites in human and rodent lymphoid cells. J Pineal Res 1995; 18:119-126.
    • (1995) J Pineal Res , vol.18 , pp. 119-126
    • Calvo, J.R.1    Rafii-Elidrissi, M.2    Pozo, D.3    Guerrero, J.M.4
  • 56
    • 0026666917 scopus 로고
    • Interaction of melatonin with human lymphocytes: Evidence for binding sites coupled to potentiation of cyclic AMP stimulated by vasoactive intestinal peptide and activation of cyclic GMP
    • Lopez-Gonzales MA, Calvo JR, Osuna C, Guerrero JM: Interaction of melatonin with human lymphocytes: Evidence for binding sites coupled to potentiation of cyclic AMP stimulated by vasoactive intestinal peptide and activation of cyclic GMP. J Pineal Res 1992; 12:97104.
    • (1992) J Pineal Res , vol.12 , pp. 97104
    • Lopez-Gonzales, M.A.1    Calvo, J.R.2    Osuna, C.3    Guerrero, J.M.4
  • 57
    • 0026639790 scopus 로고
    • Synergistic action of melatonin and vasoactive intestinal peptide in stimulating cyclic AMP production in human lymphocytes
    • Lopez-Gonzales MA, Calvo JR, Osuna C, Rubio A, Guerrero JM: Synergistic action of melatonin and vasoactive intestinal peptide in stimulating cyclic AMP production in human lymphocytes. J Pineal Res 1992;12:174-180.
    • (1992) J Pineal Res , vol.12 , pp. 174-180
    • Lopez-Gonzales, M.A.1    Calvo, J.R.2    Osuna, C.3    Rubio, A.4    Guerrero, J.M.5
  • 58
    • 0027423783 scopus 로고
    • Characterization of melatonin binding sites in human peripheral blood neutrophils
    • Lopez-Gonzales MA, Calvo JR, Segura JJ, Guerrero JM: Characterization of melatonin binding sites in human peripheral blood neutrophils. Biotechnol Ther 1993;4:253-262.
    • (1993) Biotechnol Ther , vol.4 , pp. 253-262
    • Lopez-Gonzales, M.A.1    Calvo, J.R.2    Segura, J.J.3    Guerrero, J.M.4
  • 60
    • 0028959537 scopus 로고
    • Specific binding of 2[125I]iodomelato-nin by rat splenocytes: Characterization and its role on regulation of cyclic AMP production
    • 125I]iodomelato-nin by rat splenocytes: Characterization and its role on regulation of cyclic AMP production. J Neuroim-munol 1995;57:171-178.
    • (1995) J Neuroim-Munol , vol.57 , pp. 171-178
    • Rafii-Elidrissi, M.1    Calvo, J.R.2    Pozo, D.3    Harmouch, A.4    Guerrero, J.M.5
  • 62
    • 0030026472 scopus 로고    scopus 로고
    • Specific binding of 2[125I]melatonin by rat spleen crude membranes: Day/night variations and effect of pinealecto-my and continuous light exposure
    • 125I]melatonin by rat spleen crude membranes: Day/night variations and effect of pinealecto-my and continuous light exposure. J Pineal Res 1996;20:33-38.
    • (1996) J Pineal Res , vol.20 , pp. 33-38
    • Rafii-Elidrissi, M.1    Calvo, J.R.2    Giordano, M.3    Guerrero, J.M.4
  • 63
    • 0024357395 scopus 로고
    • Melatonin inhibits cyclic AMP production in cultured ovine pars tuberalis cells
    • Morgan PJ, Lawson W, Davidson G, Howell HE: Melatonin inhibits cyclic AMP production in cultured ovine pars tuberalis cells. J Mol Endocrinol 1989;3:R5-R8.
    • (1989) J Mol Endocrinol , vol.3 , pp. R5-R8
    • Morgan, P.J.1    Lawson, W.2    Davidson, G.3    Howell, H.E.4
  • 64
    • 0025788113 scopus 로고
    • Melatonin binding sites in the central nervous system
    • Stankov B, Fraschini F, Reiter RJ: Melatonin binding sites in the central nervous system. Brain Res Rev 1991;16:245-256.
    • (1991) Brain Res Rev , vol.16 , pp. 245-256
    • Stankov, B.1    Fraschini, F.2    Reiter, R.J.3
  • 66
    • 0024462649 scopus 로고
    • Melatonin signal transduction in hamster brain: Inhibition of adenyl cyclase by a pertussis toxin-sensitive G protein
    • Carlson LL, Weaver DR, Reppert SM: Melatonin signal transduction in hamster brain: Inhibition of adenyl cyclase by a pertussis toxin-sensitive G protein. Endocrinology 1989;125:2670-2676.
    • (1989) Endocrinology , vol.125 , pp. 2670-2676
    • Carlson, L.L.1    Weaver, D.R.2    Reppert, S.M.3
  • 67
    • 0025323586 scopus 로고
    • Characterization of melatonin receptors in the rat area postrema: Modulation of affinity with cations and guanine nucleotides
    • Laitinen JT, Flügge G, Saavedra JM: Characterization of melatonin receptors in the rat area postrema: Modulation of affinity with cations and guanine nucleotides. Neuroendocrinology 1990;51:619-624.
    • (1990) Neuroendocrinology , vol.51 , pp. 619-624
    • Laitinen, J.T.1    Flügge, G.2    Saavedra, J.M.3
  • 70
    • 0027725205 scopus 로고
    • Distribution of melatonin in mammalian tissues: The relative importance of nuclear versus cytosolic localization
    • Menendez-Pelaez A, Reiter RJ: Distribution of melatonin in mammalian tissues: The relative importance of nuclear versus cytosolic localization. J Pineal Res 1993;15:59-69.
    • (1993) J Pineal Res , vol.15 , pp. 59-69
    • Menendez-Pelaez, A.1    Reiter, R.J.2
  • 73
    • 0025871491 scopus 로고
    • Melatonin modifies calmodulin cell levels in MDCK and NIE-115 cell lines and inhibits phosphodiesterase activity in vitro
    • Benitez-King G, Huerto-Delgadillo L, Anton-Tay F: Melatonin modifies calmodulin cell levels in MDCK and NIE-115 cell lines and inhibits phosphodiesterase activity in vitro. Brain Res 1991;557:289-292.
    • (1991) Brain Res , vol.557 , pp. 289-292
    • Benitez-King, G.1    Huerto-Delgadillo, L.2    Anton-Tay, F.3
  • 76
    • 0001327186 scopus 로고
    • Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum
    • Pozo D, Reiter RJ, Calvo JR, Guerrero JM: Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sci 1994;55:PL445-PL460.
    • (1994) Life Sci , vol.55 , pp. PL445-PL460
    • Pozo, D.1    Reiter, R.J.2    Calvo, J.R.3    Guerrero, J.M.4
  • 78
    • 0029055175 scopus 로고
    • Oxidative processes and antioxidative defense mechanism in the aging brain
    • Reiter RJ: Oxidative processes and antioxidative defense mechanism in the aging brain. FASEB J 1995;9: 526-533.
    • (1995) FASEB J , vol.9 , pp. 526-533
    • Reiter, R.J.1
  • 80
    • 15444342421 scopus 로고
    • Specific binding in vitro and in vivo effects of melatonin on melanoma B16 and its metastatic growth
    • June, Jerusalem
    • Stankov B, Scaglione F, Lucini V, Fraschini F: Specific binding in vitro and in vivo effects of melatonin on melanoma B16 and its metastatic growth. Proc 16th Int Congr Che-mother June, Jerusalem, 1989, pp 893,1-893,3.
    • (1989) Proc 16Th Int Congr Che-Mother , pp. 1-893
    • Stankov, B.1    Scaglione, F.2    Lucini, V.3    Fraschini, F.4
  • 81
    • 0024446479 scopus 로고
    • Growth inhibitory and cytotoxic effects of melatonin and its metabolites on human tumor cell lines in vitro
    • Shellard SA, Whealan RD, Hill BT: Growth inhibitory and cytotoxic effects of melatonin and its metabolites on human tumor cell lines in vitro. Br J Cancer 1989;60:288-290.
    • (1989) Br J Cancer , vol.60 , pp. 288-290
    • Shellard, S.A.1    Whealan, R.D.2    Hill, B.T.3
  • 82
    • 0027065157 scopus 로고
    • Is melatonin really an in vitro inhibitor of human breast cancer cell proliferation?
    • L’Hermite-Balerieaux M, de Lau-noit Y: Is melatonin really an in vitro inhibitor of human breast cancer cell proliferation? In Vitro Cell Dev Biol 1992;28A:583-584.
    • (1992) In Vitro Cell Dev Biol , vol.28A , pp. 583-584
    • L’hermite-Balerieaux, M.1    De Lau-Noit, Y.2
  • 83
    • 0026584854 scopus 로고
    • Antitumor activity of the pineal gland: Effect of unidentified substances versus the effect of melatonin
    • Bartsch H, Bartsch C, Simon WE, Flehmig B, Ebels I, Lippert TH: Antitumor activity of the pineal gland: Effect of unidentified substances versus the effect of melatonin. Oncology 1992;49:27-30.
    • (1992) Oncology , vol.49 , pp. 27-30
    • Bartsch, H.1    Bartsch, C.2    Simon, W.E.3    Flehmig, B.4    Ebels, I.5    Lippert, T.H.6
  • 84
    • 0026700132 scopus 로고
    • The pineal gland and cancer: Facts, hypotheses and perspectives
    • Bartsch C, Bartsch H, Lippert TH: The pineal gland and cancer: Facts, hypotheses and perspectives. Cancer J 1992;5:194-199.
    • (1992) Cancer J , vol.5 , pp. 194-199
    • Bartsch, C.1    Bartsch, H.2    Lippert, T.H.3
  • 85
    • 0028441269 scopus 로고
    • Interaction between melatonin and estradiol on morphological and morphometric features of MCF-7 human breast cancer cells
    • Crespo D, Fernandez-Viadero C, Verduga R, Ovejero V, Cos S: Interaction between melatonin and estradiol on morphological and morphometric features of MCF-7 human breast cancer cells. J Pineal Res 1994;16:215-222.
    • (1994) J Pineal Res , vol.16 , pp. 215-222
    • Crespo, D.1    Fernandez-Viadero, C.2    Verduga, R.3    Ovejero, V.4    Cos, S.5
  • 86
    • 0023698530 scopus 로고
    • Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture
    • Hill SM, Blask DE: Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. Cancer Res 1988;48:6121-6126.
    • (1988) Cancer Res , vol.48 , pp. 6121-6126
    • Hill, S.M.1    Blask, D.E.2
  • 87
    • 0028043174 scopus 로고
    • Differences between pulsatile or continuous exposure to melatonin on MCF-7 human breast cancer cell proliferation
    • Cos S, Sanchez-Barcelo EJ: Differences between pulsatile or continuous exposure to melatonin on MCF-7 human breast cancer cell proliferation. Cancer Lett 1994;85: 105-109.
    • (1994) Cancer Lett , vol.85 , pp. 105-109
    • Cos, S.1    Sanchez-Barcelo, E.J.2
  • 88
    • 0028981509 scopus 로고
    • Melatonin inhibition of MCF-7 human breast cancer cells growth: Influence of cell proliferation rate
    • Cos S, Sanchez-Barcelo EJ: Melatonin inhibition of MCF-7 human breast cancer cells growth: Influence of cell proliferation rate. Cancer Lett 1995;93:207-212.
    • (1995) Cancer Lett , vol.93 , pp. 207-212
    • Cos, S.1    Sanchez-Barcelo, E.J.2
  • 89
    • 0025341936 scopus 로고
    • Effects of the pineal hormone melatonin on the anchorage independent growth of human breast cancer cells (MCF-7) in a clonogenic culture system
    • Cos S, Blask DE: Effects of the pineal hormone melatonin on the anchorage independent growth of human breast cancer cells (MCF-7) in a clonogenic culture system. Cancer Lett 1990;50:115-119.
    • (1990) Cancer Lett , vol.50 , pp. 115-119
    • Cos, S.1    Blask, D.E.2
  • 90
    • 0026769322 scopus 로고
    • The growth inhibitory action of melatonin on human breast cancer cells is linked to the estrogen response system
    • Hill SM, Spriggs LL, Simon MA, Muraoka H, Blask DE: The growth inhibitory action of melatonin on human breast cancer cells is linked to the estrogen response system. Cancer Res 1992;64:249-256.
    • (1992) Cancer Res , vol.64 , pp. 249-256
    • Hill, S.M.1    Spriggs, L.L.2    Simon, M.A.3    Muraoka, H.4    Blask, D.E.5
  • 91
    • 0028490843 scopus 로고
    • Melatonin modulates growth factor activity in MCF-7 human breast cancer cells
    • Cos S, Blask DE: Melatonin modulates growth factor activity in MCF-7 human breast cancer cells. J Pineal Res 1994;17:25-32.
    • (1994) J Pineal Res , vol.17 , pp. 25-32
    • Cos, S.1    Blask, D.E.2
  • 92
    • 0022498928 scopus 로고
    • Effects of melatonin on cancer: Studies on MCF-7 human breast cancer cells in culture
    • Blask DE, Hill SM: Effects of melatonin on cancer: Studies on MCF-7 human breast cancer cells in culture. J Neural Transm suppl 1986;21: 433-449.
    • (1986) J Neural Transm Suppl , vol.21 , pp. 433-449
    • Blask, D.E.1    Hill, S.M.2
  • 93
    • 0030032765 scopus 로고    scopus 로고
    • Modulation of the length of the cell cycle time of MCF-7 human breast cancer cells by melatonin
    • Cos S, Recio J, Sanchez-Barcelo EJ: Modulation of the length of the cell cycle time of MCF-7 human breast cancer cells by melatonin. Life Sci 1996;58:811-816.
    • (1996) Life Sci , vol.58 , pp. 811-816
    • Cos, S.1    Recio, J.2    Sanchez-Barcelo, E.J.3
  • 94
    • 0029591618 scopus 로고
    • Melatonin blocks the stimulatory effects of prolactin on human breast cancer cell growth in culture
    • Lemus-Wilson A, Kelly PA, Blask DE: Melatonin blocks the stimulatory effects of prolactin on human breast cancer cell growth in culture. Br J Cancer 1995;72:1435-1440.
    • (1995) Br J Cancer , vol.72 , pp. 1435-1440
    • Lemus-Wilson, A.1    Kelly, P.A.2    Blask, D.E.3
  • 95
    • 0028054749 scopus 로고
    • Melatonin receptors: Localization, molecular pharmacology and physiological significance
    • Morgan PJ, Barrett P, Howell HE, Helliwell R: Melatonin receptors: Localization, molecular pharmacology and physiological significance. Neurochem Int 1994;24:101-146.
    • (1994) Neurochem Int , vol.24 , pp. 101-146
    • Morgan, P.J.1    Barrett, P.2    Howell, H.E.3    Helliwell, R.4
  • 99
    • 0027198134 scopus 로고
    • Human malignant melanoma cells express high-affinity receptors for melatonin: Antiproliferative effects of melatonin and 6-chloromelatonin
    • Ying SW, Niles LP, Crocker C: Human malignant melanoma cells express high-affinity receptors for melatonin: Antiproliferative effects of melatonin and 6-chloromelatonin. Eur J Pharmacol 1993;246:89-96.
    • (1993) Eur J Pharmacol , vol.246 , pp. 89-96
    • Ying, S.W.1    Niles, L.P.2    Crocker, C.3
  • 101
    • 0027421106 scopus 로고
    • Melatonin modulation of estrogen receptor expression in MCF-7 human breast cancer cells
    • Molis TM, Walters SM, Hill SM: Melatonin modulation of estrogen receptor expression in MCF-7 human breast cancer cells. Int J Oncol 1993;3:687-694.
    • (1993) Int J Oncol , vol.3 , pp. 687-694
    • Molis, T.M.1    Walters, S.M.2    Hill, S.M.3
  • 102
    • 1842646482 scopus 로고
    • Melatonin increases cfos mRNA in MCF-7 human breast cancer cells (Abstract 773.5)
    • Hull KM, Maher TJ, Jorgenson JL: Melatonin increases cfos mRNA in MCF-7 human breast cancer cells (abstract 773.5). Soc Neurosci, 1993, vol 19, pp 1896.
    • (1993) Soc Neurosci , vol.19 , pp. 1896
    • Hull, K.M.1    Maher, T.J.2    Jorgenson, J.L.3
  • 104
    • 0025828360 scopus 로고
    • Effects of melatonin on the cell cycle kinetics and estrogen rescue of MCF-7 human breast cancer cells in culture
    • Cos S, Blask DE, Lemus-Wilson A, Hill AB: Effects of melatonin on the cell cycle kinetics and estrogen rescue of MCF-7 human breast cancer cells in culture. J Pineal Res 1991;10:36-42.
    • (1991) J Pineal Res , vol.10 , pp. 36-42
    • Cos, S.1    Blask, D.E.2    Lemus-Wilson, A.3    Hill, A.B.4
  • 105
  • 106
    • 0023944689 scopus 로고
    • Expression of transforming growth factor alpha and its messenger ribonucleic acid in human breast cancer: Its regulation by estrogen and its possible functional significance
    • Bates SE, Davidson NE, Valverius EM, Freter CE, Dickson RB, Tam JP, Kudlow JE, Lippman ME, Salomon DS: Expression of transforming growth factor alpha and its messenger ribonucleic acid in human breast cancer: Its regulation by estrogen and its possible functional significance. Mol Endocrinol 1988;2:543-555.
    • (1988) Mol Endocrinol , vol.2 , pp. 543-555
    • Bates, S.E.1    Davidson, N.E.2    Valverius, E.M.3    Freter, C.E.4    Dickson, R.B.5    Tam, J.P.6    Kudlow, J.E.7    Lippman, M.E.8    Salomon, D.S.9
  • 107
    • 0022631868 scopus 로고
    • Induction of epidermal growth factor-related polypeptides by 17 beta-estradiol in MCF-7 human breast cancer cells
    • Dickson RB, Huff KK, Spencer EM, Lippman ME: Induction of epidermal growth factor-related polypeptides by 17 beta-estradiol in MCF-7 human breast cancer cells. Endocrinology 1986;118: 138-142.
    • (1986) Endocrinology , vol.118 , pp. 138-142
    • Dickson, R.B.1    Huff, K.K.2    Spencer, E.M.3    Lippman, M.E.4
  • 108
    • 0022558505 scopus 로고
    • Ca2+ and calmodulin are involved in the processes conferring stability to DNA in proliferating neoplastic cells
    • 2+ and calmodulin are involved in the processes conferring stability to DNA in proliferating neoplastic cells. Int J Cancer 1986;37:891-896.
    • (1986) Int J Cancer , vol.37 , pp. 891-896
    • Lonn, U.1    Lonn, S.2
  • 110
    • 0025678608 scopus 로고
    • Melatonin effects on the cytoskeletal organisation of MDCK and neuroblastoma N1E-115 cells
    • Benitez-King G, Huerto-Delgadil-lo L, Anton-Tay F: Melatonin effects on the cytoskeletal organisation of MDCK and neuroblastoma N1E-115 cells. J Pineal Res 1990; 9:209-220.
    • (1990) J Pineal Res , vol.9 , pp. 209-220
    • Benitez-King, G.1    Huerto-Delgadillo, L.2    Anton-Tay, F.3
  • 111
    • 0028137186 scopus 로고
    • Melatonin: A peroxyl radical scavenger more effective than vitamin E
    • Pieri C, Marra M, Moroni F, Rec-chioni R, Marcheselli F: Melatonin: A peroxyl radical scavenger more effective than vitamin E. Life Sci 1994;55:PL271-PL276.
    • (1994) Life Sci , vol.55 , pp. PL271-PL276
    • Pieri, C.1    Marra, M.2    Moroni, F.3    Rec-Chioni, R.4    Marcheselli, F.5
  • 113
    • 0000482675 scopus 로고
    • Melatonin action on human breast cancer cells: Involvement of glutathione metabolism and redox environment;
    • Fraschini F, Reiter RJ, Stankov B (eds):, New York, Plenum
    • Blask DE, Wilson ST: Melatonin action on human breast cancer cells: Involvement of glutathione metabolism and redox environment; in Fraschini F, Reiter RJ, Stankov B (eds): The Pineal Gland and Its Hormones: Fundamental and Clinical Perspectives. NATO ASI Series, Life Sci. New York, Plenum, 1995, vol 204, pp 209-217.
    • (1995) The Pineal Gland and Its Hormones: Fundamental and Clinical Perspectives. NATO ASI Series, Life Sci. , vol.204 , pp. 209-217
    • Blask, D.E.1    Wilson, S.T.2
  • 114
    • 0028983511 scopus 로고
    • Melatonin protects human blood lymphocytes from radiation-induced chromosome damage
    • Vijayalaxmi, Reiter RJ, Meltz ML: Melatonin protects human blood lymphocytes from radiation-induced chromosome damage. Mu-tat Res 1995;346:23-31.
    • (1995) Mu-Tat Res , vol.346 , pp. 23-31
    • Vijayalaxmi, R.R.1    Meltz, M.L.2
  • 115
    • 0023025530 scopus 로고
    • Inhibitory effects of the pineal hormone melatonin and underfeeding during the promotional phase of 7, 12-dimethylbenzan-thracene (DMBA)-induced mammary tumorigenesis
    • Blask DE, Hill SM, Orstead KM, Massa JS: Inhibitory effects of the pineal hormone melatonin and underfeeding during the promotional phase of 7, 12-dimethylbenzan-thracene (DMBA)-induced mammary tumorigenesis. J Neural Transm 1986;67:125-138.
    • (1986) J Neural Transm , vol.67 , pp. 125-138
    • Blask, D.E.1    Hill, S.M.2    Orstead, K.M.3    Massa, J.S.4
  • 116
    • 0023707744 scopus 로고
    • Influence of dietary fat, caloric restriction and voluntary exercise on N-nitrosomethylurea-induced mammary tumorigenesis in rats
    • Cohen LA, Choi K, Wang CX: Influence of dietary fat, caloric restriction and voluntary exercise on N-nitrosomethylurea-induced mammary tumorigenesis in rats. Cancer Res 1988;48:426-428.
    • (1988) Cancer Res , vol.48 , pp. 426-428
    • Cohen, L.A.1    Choi, K.2    Wang, C.X.3
  • 117
    • 0026537395 scopus 로고
    • Dietary energy and fat effect on tumor promotion
    • Birt DF, Kris ES, Choe M, Pelling JC: Dietary energy and fat effect on tumor promotion. Cancer Res 1992;52(suppl):2035s-2039s.
    • (1992) Cancer Res , vol.52 , pp. 2035s-2039s
    • Birt, D.F.1    Kris, E.S.2    Choe, M.3    Pelling, J.C.4
  • 119
    • 54249170227 scopus 로고    scopus 로고
    • Melatonin suppression of tumor growth in vivo: A novel mechanism involving inhibition of fatty acid uptake and metabolism
    • Maestroni GJ, Conti A, Reiter RJ (eds):, Basel, Karger
    • Blask DE, Sauer LA, Dauchy RT: Melatonin suppression of tumor growth in vivo: A novel mechanism involving inhibition of fatty acid uptake and metabolism; in Maestroni GJ, Conti A, Reiter RJ (eds): Therapeutic Potential of Melatonin. Front Horm Res. Basel, Karger, 1997, vol 23, pp 107-114.
    • (1997) Therapeutic Potential of Melatonin. Front Horm Res. , vol.23 , pp. 107-114
    • Blask, D.E.1    Sauer, L.A.2    Dauchy, R.T.3
  • 122
    • 0026410051 scopus 로고
    • Clinical results with the pineal hormone melatonin in advanced cancer resistant to standard antitumor therapies
    • Lissoni P, Barni S, Cattaneo G, Tancini G, Esposti G, Esposti D, Fraschini F: Clinical results with the pineal hormone melatonin in advanced cancer resistant to standard antitumor therapies. Oncology 1991;48:448-450.
    • (1991) Oncology , vol.48 , pp. 448-450
    • Lissoni, P.1    Barni, S.2    Cattaneo, G.3    Tancini, G.4    Esposti, G.5    Esposti, D.6    Fraschini, F.7
  • 125
    • 0027817009 scopus 로고
    • Subcutaneous therapy with low-dose interleukin-2 plus the neurohormone melatonin in metastatic gastric cancer patients with low performance status
    • Lissoni P, Brivio F, Ardizzoia A, Tancini G, Barni S: Subcutaneous therapy with low-dose interleukin-2 plus the neurohormone melatonin in metastatic gastric cancer patients with low performance status. Tumori 1993;79:401-404.
    • (1993) Tumori , vol.79 , pp. 401-404
    • Lissoni, P.1    Brivio, F.2    Ardizzoia, A.3    Tancini, G.4    Barni, S.5
  • 126
    • 0028156791 scopus 로고
    • A randomized study with the pineal hormone melatonin versus supportive care alone in patients with brain metastases due to solid neoplasms
    • Lissoni P, Barni S, Ardizzoia A, Tancini G, Conti A, Maestroni GJ: A randomized study with the pineal hormone melatonin versus supportive care alone in patients with brain metastases due to solid neoplasms. Cancer 1994;73:699-701.
    • (1994) Cancer , vol.73 , pp. 699-701
    • Lissoni, P.1    Barni, S.2    Ardizzoia, A.3    Tancini, G.4    Conti, A.5    Maestroni, G.J.6
  • 127
    • 0028219170 scopus 로고
    • Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first line therapy in locally advanced or metastatic hepatocellular carcinoma
    • Aldeghi R, Lissoni P, Barni S, Ar-dizzoia A, Tancini G, Piperno A, Pozzi M, Ricci G, Conti A, Maes-troni GJ: Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first line therapy in locally advanced or metastatic hepatocellular carcinoma. Eur J Cancer 1994;30:167-170.
    • (1994) Eur J Cancer , vol.30 , pp. 167-170
    • Aldeghi, R.1    Lissoni, P.2    Barni, S.3    Ar-Dizzoia, A.4    Tancini, G.5    Piperno, A.6    Pozzi, M.7    Ricci, G.8    Conti, A.9    Maes-Troni, G.J.10
  • 128
    • 0028937541 scopus 로고
    • Modulation of cancer endocrine therapy by melatonin: A phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone
    • Lissoni P, Barni S, Meregalli S, Fossati V, Cazzaniga M, Esposti D, Tancini G: Modulation of cancer endocrine therapy by melatonin: A phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone. Br J Cancer 1995;71:854-856.
    • (1995) Br J Cancer , vol.71 , pp. 854-856
    • Lissoni, P.1    Barni, S.2    Meregalli, S.3    Fossati, V.4    Cazzaniga, M.5    Esposti, D.6    Tancini, G.7
  • 130
    • 0028626331 scopus 로고
    • A randomized study of immunotherapy with low-dose subcutaneous interleukin-2 plus melatonin vs chemotherapy with cisplatin and etoposide as first-line therapy for advanced non-small cell lung cancer
    • Lissoni P, Meregalli S, Fossati V, Paolorossi F, Barni S, Tancini G, Frigerio F: A randomized study of immunotherapy with low-dose subcutaneous interleukin-2 plus melatonin vs chemotherapy with cisplatin and etoposide as first-line therapy for advanced non-small cell lung cancer. Tumori 1994;80: 464-467.
    • (1994) Tumori , vol.80 , pp. 464-467
    • Lissoni, P.1    Meregalli, S.2    Fossati, V.3    Paolorossi, F.4    Barni, S.5    Tancini, G.6    Frigerio, F.7
  • 131
    • 0028811266 scopus 로고
    • Efficacy and tolerability of cancer neuroimmunotherapy with subcutaneous low-dose interleukin-2 and the pineal hormone melatonin: A progress report of 200 patients with advanced solid neoplasms
    • Lissoni P, Ardizzoia A, Barni S, Brivio F, Tisi E, Rovelli F, Tancini G, Maestroni GJ, Fumagalli L: Efficacy and tolerability of cancer neuroimmunotherapy with subcutaneous low-dose interleukin-2 and the pineal hormone melatonin: A progress report of 200 patients with advanced solid neoplasms. Oncol Rep 1995;2:1063-1068.
    • (1995) Oncol Rep , vol.2 , pp. 1063-1068
    • Lissoni, P.1    Ardizzoia, A.2    Barni, S.3    Brivio, F.4    Tisi, E.5    Rovelli, F.6    Tancini, G.7    Maestroni, G.J.8    Fumagalli, L.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.